The structure and function of the glucagon-like peptide-1 receptor and its ligands

Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity

(2011) Nian Gong et al.   BRITISH JOURNAL OF PHARMACOLOGY

GLP-1 for type 2 diabetes

(2011) Bo Ahrén   EXPERIMENTAL CELL RESEARCH

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

(2011) Laurence J. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional association of the N-terminal residues with the central region in glucagon-related peptides

(2011) James T. Patterson et al.   JOURNAL OF PEPTIDE SCIENCE

Biomimetic Screening of Class-B G Protein-Coupled Receptors

(2011) Christian Devigny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

(2010) James T. Patterson et al.   ACS Chemical Biology

Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor

(2010) Quan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recombinant Expression, in Vitro Refolding, and Biophysical Characterization of the Human Glucagon-like Peptide-1 Receptor

(2010) Kathrin Schröder-Tittmann et al.   BIOCHEMISTRY

Structural study of an active analog of EX-4 in solution and micelle associated states

(2010) Shuo Wang et al.   BIOPOLYMERS

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4

(2010) RJ Mann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets

(2010) K. W. Sloop et al.   DIABETES

Spatial Approximations between Residues 6 and 12 in the Amino-terminal Region of Glucagon-like Peptide 1 and Its Receptor

(2010) Quan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational and Cysteine Scanning Analysis of the Glucagon Receptor N-terminal Domain

(2010) Martine Prévost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Potent Glucagon-like Peptide-1 Agonists with High Enzyme Stability via Introduction of Multiple Lactam Bridges

(2010) Eunice N. Murage et al.   JOURNAL OF MEDICINAL CHEMISTRY

Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action

(2010) Jonathan W. Day et al.   JOURNAL OF PEPTIDE SCIENCE

Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent "Compound 2" at the GLP-1 Receptor

(2010) K. Coopman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids

(2010) D. Wootten et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

(2010) C. Koole et al.   MOLECULAR PHARMACOLOGY

Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket

(2010) Rosalind J. Mann et al.   PEPTIDES

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

(2010) Kaleeckal G. Harikumar et al.   REGULATORY PEPTIDES

GLP-1 protects β-cells against apoptosis by enhancing the activity of an IGF-2/IGF1-receptor autocrine loop

(2010) Marion Cornu et al.   Islets

Liraglutide: A Once-Daily Incretin Mimetic for the Treatment of Type 2 Diabetes Mellitus

(2009) Joshua J Neumiller et al.   ANNALS OF PHARMACOTHERAPY

Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor

(2009) Y Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

(2009) Nigel Irwin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Basis of Glucagon-like Peptide 1 Docking to Its Intact Receptor Studied with Carboxyl-terminal Photolabile Probes

(2009) Quan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity

(2009) Claudio Mapelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

(2009) Jonathan W Day et al.   Nature Chemical Biology

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

(2009) Christoph Parthier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Search for α-helical propensity in the receptor-bound conformation of glucagon-like peptide-1

(2008) Eunice N. Murage et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular modeling of the three-dimensional structure of GLP-1R and its interactions with several agonists

(2008) Fu Lin et al.   JOURNAL OF MOLECULAR MODELING

Insights into the Structural Basis of Endogenous Agonist Activation of Family B G Protein-Coupled Receptors

(2008) Maoqing Dong et al.   MOLECULAR ENDOCRINOLOGY

GLP-1 (9-36) Amide, Cleavage Product of GLP-1 (7-36) Amide, Is a Glucoregulatory Peptide

(2008) Dariush Elahi et al.   Obesity

Boc5, a Non-Peptidic Glucagon-Like Peptide-1 Receptor Agonist, Invokes Sustained Glycemic Control and Weight Loss in Diabetic Mice

(2008) Haoran Su et al.   PLoS One

Class-B GPCR activation: is ligand helix-capping the key?

(2008) Jean-Michel Neumann et al.   TRENDS IN BIOCHEMICAL SCIENCES