Article
Cell Biology
Pingyang Ke, Juan Gu, Jing Liu, Yan Liu, Xin Tian, Yuanlin Ma, Yuan Meng, Fei Xiao
Summary: Epilepsy, affecting over 65 million people, is a common neurological disorder with unknown mechanisms. Abnormal synaptic transmission plays a crucial role in its occurrence and development. Syntabulin, a neuronal transporter, is found to be increased in epileptic tissues, and its knockdown increases susceptibility and severity of epilepsy, while overexpression has the opposite effect. Syntabulin mainly translocates STX1B to the presynaptic membrane in epileptic brain tissue, resulting in increased presynaptic transmitter release. It plays a significant role in the E/I balance of GABAergic activity and regulates the epileptic phenotype.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Joohyung Kim, Sungdae Kim, Minyeop Nahm, Tsai-Ning Li, Hsin-Chieh Lin, Yeongjin David Kim, Jihye Lee, Chi-Kuang Yao, Seungbok Lee
Summary: Research has shown that the Drosophila homologue of ALS2 plays crucial roles in endosomal trafficking, synaptic development, and neuronal survival. Loss of dALS2 results in age-dependent progressive defects resembling amyotrophic lateral sclerosis, independently of the FNI pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biology
Abagael M. Lasseigne, Fabio A. Echeverry, Sundas Ijaz, Jennifer Carlisle Michel, E. Anne Martin, Audrey J. Marsh, Elisa Trujillo, Kurt C. Marsden, Alberto E. Pereda, Adam C. Miller
Summary: This study investigated the functional relationship between neuronal Connexins and ZO1, revealing that ZO1 is crucial for the localization of synaptic Connexins, while Connexins are not necessary for ZO1 localization. Disruption of this hierarchical ZO1/Connexin relationship abolishes electrical transmission and disrupts Mauthner cell-initiated escape responses.
Article
Neurosciences
Wenhui Qu, Kiall F. Suazo, Wenfeng Liu, Shaowu Cheng, Angela Jeong, David Hottman, Li-Lian Yuan, Mark D. Distefano, Ling Li
Summary: Protein prenylation is crucial for regulating cellular signaling pathways, with FT and GGT enzymes playing essential roles in the process. FT haplodeficiency rescues cognitive function in Alzheimer's disease models, whereas GGT deficiency leads to synaptic and cognitive deficits. A novel prenylomic analysis identifies distinct pools of prenylated proteins affected by specific knockout of FT and GGT in forebrain neurons, indicating their essential roles in synaptic and cognitive functions.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Marijn Kuijpers, Gaga Kochlamazashvili, Alexander Stumpf, Dmytro Puchkov, Aarti Swaminathan, Max Thomas Lucht, Eberhard Krause, Tanja Maritzen, Dietmar Schmitz, Volker Haucke
Summary: This study demonstrates that loss of neuronal autophagy leads to selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo. The elevated excitatory neurotransmission is caused by increased calcium release from ER stores via ryanodine receptors accumulated in axons and at presynaptic sites. Neuronal autophagy controls axonal ER calcium stores to regulate neurotransmission in healthy neurons and in the brain.
Article
Biochemistry & Molecular Biology
Pedro Valada, Sofia Alcada-Morais, Rodrigo A. Cunha, Joao Pedro Lopes
Summary: Theobromine, a metabolite of caffeine, affects synaptic transmission and plasticity by antagonizing adenosine receptors, resulting in improved cognitive function and neuroprotection against disease-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lisa Marie Walter, Sebastian Rademacher, Andreas Pich, Peter Claus
Summary: Under stress conditions, nuclear and cytoplasmic actin-cofilin rods are transiently formed to reduce actin filament turnover and ATP hydrolysis. The presence of actin rods in Spinal Muscular Atrophy (SMA) highlights the importance of dysregulated actin dynamics in motoneuron loss. Analysis of the composition of actin rods in a SMA cell culture model revealed binding of proteins involved in ubiquitination, translation, and protein folding, suggesting sequestration of these proteins and impairment of essential cellular functions. Involvement of profilin2 and its upstream effectors RhoA/ROCK in actin rod assembly in SMA indicates detrimental effects on motoneuron homeostasis by affecting actin dynamics and disturbing essential cellular pathways.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Jessica C. Pressey, Miranda de Saint-Rome, Vineeth A. Raveendran, Melanie A. Woodin
Summary: Synaptic inhibition plays a crucial role in regulating neuronal excitability, which depends on the neurotransmitters GABA and glycine and their effects on the Cl- gradient. CCCs, specifically NKCC1 and KCC2, regulate the Cl- gradient in neurons and play a critical role in healthy brain function. Understanding the mechanisms of CCC regulation and their impact on inhibitory synaptic plasticity can provide insights into neurological disorders. Techniques for estimating and recording intracellular Cl- can be useful for researchers interested in studying CCCs and neuronal excitability. Additionally, nonneuronal cells regulate neuronal excitability by modulating Cl- levels, and CCC-mediated alterations in neuronal excitability are implicated in neurological disorders.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Xianli Shen, Yiguo Qiu, Andrew E. Wight, Hye-Jung Kim, Harvey Cantor
Summary: Expression of CD11c and OPN marks a stable microglial subset in the brain, independent of environmental activation stimuli. OPN is required for subset stability and the execution of phagocytic and proinflammatory responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Hui Hong, Huicheng Chen, Yuxia Zhang, Zhimao Wu, Yingying Zhang, Yingyi Zhang, Zeng Hu, Jian V. Zhang, Kun Ling, Jinghua Hu, Qing Wei
Summary: Coordination of neurite extension with surrounding glia development is crucial for neuronal function. DYF-4, a glia-secreted protein, functions as a regulator for DAF-6 to control sensory compartment formation, indirectly affecting neurite extension and ciliogenesis.
Article
Neurosciences
Junli Zhao, Sangsu Bang, Kenta Furutani, Aidan Mcginnis, Changyu Jiang, Alexus Roberts, Christopher R. Donnelly, Qianru He, Michael L. James, Miles Berger, Mei-Chuan Ko, Haichen Wang, Richard D. Palmiter, Ru-Rong Ji
Summary: Neuronal PD-1 signaling plays a crucial role in regulating learning and memory, and inhibiting PD-1 or reducing PD-L1 levels may enhance memory function.
Article
Immunology
Hana Yeh, Maya E. Woodbury, Kaitlin L. Ingraham Dixie, Tsuneya Ikezu, Seiko Ikezu
Summary: There is increasing evidence suggesting that microglia play a crucial role in synapse formation and spine growth, with the secreted morphogen WNT5A being the most abundant WNT expressed in microglia, promoting neuronal maturation. Co-culture of microglia with differentiated neurons showed increased neuronal spine density and reduced dendritic spine turnover rate, which decreased when microglial Wnt5a was silenced in vitro. Co-culture also increased post-synaptic marker PSD95 and synaptic density, while silencing Wnt5a in microglia reduced both. Furthermore, co-culture enhanced neuronal firing rate, which was reduced by silencing microglial Wnt5a during differentiation. These findings suggest the potential pathological roles of dysfunctional microglia in developmental disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Ana Catarina Ferreira, Brittany M. Hemmer, Sarah M. Philippi, Alejandro B. Grau-Perales, Jacob L. Rosenstadt, Hanxiao Liu, Jeffrey D. Zhu, Tatyana Kareva, Tim Ahfeldt, Merina Varghese, Patrick R. Hof, Joseph M. Castellano
Summary: The functional output of the hippocampus, which supports memory function, is regulated by cellular and molecular processes. This study reveals that TIMP2, a molecule highly expressed in the hippocampus, plays a role in cellular programs related to neurogenesis and dendritic spine turnover. Its loss leads to impairments in hippocampus-dependent memory. This research provides insights into the regulation of synaptic plasticity by TIMP2.
MOLECULAR PSYCHIATRY
(2023)
Article
Oncology
Hannah J. Uckelmann, Elena L. Haarer, Reina Takeda, Eric M. Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J. C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun -Wei Chen, Scott A. Armstrong
Summary: The dysregulation of developmental and stem cell-associated genes is a common phenomenon during cancer development. Most patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1, with an NPM1 mutation (NPM1c) being common in these cases. This study reveals that NPM1c directly binds to specific chromatin targets, collaborates with the MLL1 complex, and directly regulates oncogenic gene expression in AML.
Article
Biochemistry & Molecular Biology
Paula Tena-Morraja, Guillem Rique-Pujol, Claudia Muller-Sanchez, Manuel Reina, Ofelia M. Martinez-Estrada, Francesc X. Soriano
Summary: Synaptic activity in the central nervous system consumes the most energy. New research reveals that an episode of synaptic activity increases mitochondrial bioenergetics by inducing the expression of iron metabolism genes, resulting in enhanced cellular and mitochondrial iron uptake. The study suggests a coordinated expression of synaptic plasticity programs and energy demands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hyo Sung Jung, Jae-Hong Lee, Kyutae Kim, Seyoung Koo, Peter Verwilst, Jonathan L. Sessler, Chulhun Kang, Jong Seung Kim
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Peter Verwilst, Hye-Ri Kim, Jinho Seo, Nak-Won Sohn, Seung-Yun Cha, Yeongmin Kim, Sungho Maeng, Jung-Won Shin, Jong Hwan Kwak, Chulhun Kang, Jong Seung Kim
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Geun-Oh Kim, Hoyeon Lee, Eungyung Ma, Chulhun Kang, Young-Uk Kwon
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2017)
Article
Biochemical Research Methods
Zhigang Yang, Dong Hoon Kang, Hoyeon Lee, Jinwoo Shin, Wei Yan, Bhowmira Rathore, Hye-Ri Kim, Seo Jin Kim, Hardev Singh, Liwei Liu, Junle Qu, Chulhun Kang, Jong Seung Kim
BIOCONJUGATE CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Youngjin Wi, Hoa Thi Le, Peter Verwilst, Kyoung Sunwoo, Seo Jin Kim, Jung Eun Song, Hey Young Yoon, Geon Han, Jong Seung Kim, Chulhun Kang, Tae Woo Kim
CHEMICAL COMMUNICATIONS
(2018)
Review
Chemistry, Multidisciplinary
Peter Verwilst, Hyeong Seok Kim, Soobin Kim, Chulhun Kang, Jong Seung Kim
CHEMICAL SOCIETY REVIEWS
(2018)
Review
Chemistry, Multidisciplinary
Min Hee Lee, Amit Sharma, Min Jung Chang, Jinju Lee, Subin Son, Jonathan L. Sessler, Chulhun Kang, Jong Seung Kim
CHEMICAL SOCIETY REVIEWS
(2018)
Article
Multidisciplinary Sciences
Chae-Seok Lim, Hye Jin Nam, Jaehyun Lee, Dongha Kim, Ja Eun Choi, SukJae Joshua Kang, Somi Kim, Hyopil Kim, Chuljung Kwak, Kyu-Won Shim, Siyong Kim, Hyoung-Gon Ko, Ro Un Lee, Eun-Hae Jang, Juyoun Yoo, Jaehoon Shim, Md Ariful Islam, Yong-Seok Lee, Jae-Hyung Lee, Sung Hee Baek, Bong-Kiun Kaang
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Shuwa Xu, Qi Xiao, Filip Cosmanescu, Alina P. Sergeeva, Juyoun Yoo, Ying Lin, Phinikoula S. Katsamba, Goran Ahlsen, Jonathan Kaufman, Nikhil T. Linaval, Pei-Tseng Lee, Hugo J. Bellen, Lawrence Shapiro, Barry Honig, Liming Tan, S. Lawrence Zipursky
Article
Biology
Yerbol Z. Kurmangaliyev, Juyoun Yoo, Samuel A. LoCascio, S. Lawrence Zipursky
Article
Neurosciences
Yerbol Z. Kurmangaliyev, Juyoun Yoo, Javier Valdes-Aleman, Piero Sanfilippo, S. Lawrence Zipursky
Article
Biochemistry & Molecular Biology
Juyoun Yoo, Mark Dombrovski, Parmis Mirshahidi, Aljoscha Nern, Samuel A. Locascio, S. Lawrence Zipursky, Yerbol Z. Kurmangaliyev
Summary: Advances in brain connectomics have revealed the complexity of neural circuits. This study integrated the synapse-level connectome with developmental expression patterns and binding specificities of cell adhesion molecules to understand the wiring specificity in the Drosophila visual system. They found that specific receptor-ligand pairs play a crucial role in synaptic localization and connections.
Article
Chemistry, Multidisciplinary
Hyo Won Lee, Myoung Ki Cho, Hye-Ri Kim, Chang Su Lim, Chulhun Kang, Hwan Myung Kim
CHEMICAL COMMUNICATIONS
(2017)
Article
Chemistry, Multidisciplinary
Sun Young Park, Woori Kim, Sun-Hee Park, Jinhyoung Han, Jinju Lee, Chulhun Kang, Min Hee Lee
CHEMICAL COMMUNICATIONS
(2017)
Article
Chemistry, Multidisciplinary
Joo Hee Jang, Woo Ri Kim, Amit Sharma, Suk Hee Cho, Tony D. James, Chulhun Kang, Jong Seung Kim
CHEMICAL COMMUNICATIONS
(2017)
