Review
Chemistry, Medicinal
Nazia Nazam, Nasimudeen R. Jabir, Iftikhar Ahmad, Saif A. Alharthy, Mohd Shahnawaz Khan, Rashid Ayub, Shams Tabrez
Summary: Cancer is a global health problem that is on the rise, and ovarian cancer is one of the leading causes of mortality worldwide. Current treatments for ovarian cancer have limited effectiveness and come with side effects, recurrence risk, and drug resistance. Therefore, there is a need for alternative, cost-effective, and safer therapeutic strategies.
Review
Chemistry, Medicinal
Srimanta Patra, Biswajita Pradhan, Rabindra Nayak, Chhandashree Behera, Krishna Chandra Panda, Surajit Das, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Despite advancements in cancer diagnosis and therapeutics, the global incidence of cancer and cancer-related mortality is expected to rise in recent years. Non-nutritive dietary phytochemicals have emerged as potent modulators of apoptosis and autophagy in various cancer cells, showing promising therapeutic potential with minimal side effects and enhanced efficacy. Developing precision and personalized medicine and utilizing dietary phytochemicals as supplements will be increasingly prevalent in cancer therapeutics.
PHYTOTHERAPY RESEARCH
(2021)
Article
Oncology
Elina Khatoon, Kishore Banik, Choudhary Harsha, Bethsebie Lalduhsaki Sailo, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Rajesh Vikkurthi, Thengujam Babita Devi, Subash C. Gupta, Ajaikumar B. Kunnumakkara
Summary: Despite advances in cancer treatment, drug resistance remains a major challenge. Phytochemicals have emerged as potential chemosensitizing agents due to their multitargeted properties and low toxicity.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Hongna Sun, Shuang Dai, Junnan Xu, Linan Liu, Jiaxing Yu, Tao Sun
Summary: Primary neuroendocrine carcinoma of the breast (NECB) is a rare and poorly differentiated subtype of breast cancer. The accurate diagnosis and treatment of NECB remain challenging due to its low incidence and lack of standardized guidelines. This review provides an overview of the latest research on the clinicopathologic characteristics, diagnosis, treatment, and prognosis of NECB, as well as new perspectives on its molecular features.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Peyman Tabnak, Soroush Masrouri, Kiarash Roustai Geraylow, Mahtab Zarei, Zanyar Haji Esmailpoor
Summary: Anesthetics play a significant role in cancer surgeries, and their effects on cancer growth and metastasis vary depending on the type of cancer and therapy administration. Recent research suggests that anesthetics can alter gene expression and cause epigenetic changes through regulating miRNAs, which may offer new insights for future studies on anesthesia-induced cancer regulation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Satbir Kour, Indrani Biswas, Sumit Sheoran, Swati Arora, Prasanna Sheela, Santosh Kumari Duppala, Dwarkanath K. Murthy, Smita C. Pawar, Himanshu Singh, Deepak Kumar, Dhamodharan Prabhu, Sugunakar Vuree, Raj Kumar
Summary: Cancer epigenetics has gained attention for its reversible nature and role in cervical tumorigenesis. Synthetic inhibitors targeting DNA methylation and chromatin modification have limitations, leading to the evaluation of bioactive phytochemicals. These phytochemicals have shown potential in altering gene expression but targeted delivery is lacking. Nano-encapsulated drugs and computational pharmaceutics employing AI and nanotechnology may offer solutions in personalized healthcare.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Agronomy
Kaili Yang, Yiqing Qing, Qifang Yu, Xiaopeng Tang, Gang Chen, Rejun Fang, Hu Liu
Summary: Industrial and agricultural by-products from crop, fruit, and vegetable processing have gained attention as animal feed in the animal feed industry. This review discusses their nutritional values and constraints in animal feeding.
Article
Pharmacology & Pharmacy
Lindsay S. Kalick, Hamaad A. Khan, Erica Maung, Yasmany Baez, Alexa N. Atkinson, Carly E. Wallace, Faith Day, Blake E. Delgadillo, Arijit Mondal, Ramida Watanapokasin, Sandra M. Barbalho, Anupam Bishayee
Summary: Mangosteen, also known as the queen of fruits, is a tropical fruit that has gained popularity due to its health-promoting attributes. It has been used in traditional medicine to treat various illnesses and has been shown to exhibit numerous biological and pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antimalarial, antidiabetic, and anticancer properties. The anticancer potential of mangosteen constituents, particularly the xanthones, is currently being studied.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Michela Palleschi, Gianluca Tedaldi, Marianna Sirico, Alessandra Virga, Paola Ulivi, Ugo De Giorgi
Summary: PARP inhibitors are effective drugs for treating tumors with BRCA1/2 mutations, with potential applications in both monotherapy and combination therapy for breast cancer, showing essential clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Frederik F. Kreiner, Philip Andreas Schytz, Hiddo J. L. Heerspink, Bernt Johan von Scholten, Thomas Idorn
Summary: Obesity is an independent risk factor for chronic kidney disease, and there is a complex interaction between obesity, kidney disease, and other cardiovascular and metabolic conditions. Current therapeutic strategies include non-pharmacological interventions and pharmacological interventions, but their efficacy and long-term sustainability are still debatable, emphasizing the need for further research.
Review
Plant Sciences
Jiao Wang, Neeraj Rani, Seema Jakhar, Rakesh Redhu, Sanjiv Kumar, Sachin Kumar, Sanjeev Kumar, Bhagwati Devi, Jesus Simal-Gandara, Bairong Shen, Rajeev K. Singla
Summary: This article reviews the anticancer properties of Opuntia ficus-indica (L.) Mill. and its potential as a natural cancer prevention and treatment agent. The study highlights the mechanisms involved, such as apoptosis, cell cycle arrest, and Bcl-2 modulation. However, further research is needed to determine the clinical utility of this resource.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Oncology
Kangsheng Liu, Xiaodong Mao, Taiping Li, Zhirong Xu, Ruifang An
Summary: Breast cancer is the most significant threat to women's health. Immunotherapy, including tumor vaccines and adoptive cell therapies, has shown promising results in the treatment of breast cancer. Tumor mutational burden (TMB) may be a predictive marker for immunotherapy in breast cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Roberta Costi, Marco Marenco, Rocco Plateroti, Antonio Minni, Giuseppe Attanasio, Marco Artico, Alessandro Lambiase
Summary: Ocular fibrosis, a major area of unmet need in ophthalmology and medicine, lacks effective treatments due to potentially blinding side effects of current therapies. Research progress includes biological mechanisms, gene therapy, chemical inhibitors, and exploration of angiogenetic and biomechanical factors, with promising results offering potential for clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Abid Naeem, Pengyi Hu, Ming Yang, Jing Zhang, Yali Liu, Weifeng Zhu, Qin Zheng
Summary: Natural products have been a valuable source of anticancer agents, providing high molecular diversity and novel biofunctionality. They are currently being investigated for their potential as cytotoxic agents and have prompted innovative strategies in cancer treatment. This review provides an overview of the emergence of natural products in cancer treatment and prevention, including their molecular mechanisms and various therapeutic approaches.
Article
Engineering, Environmental
Amrika Deonarine, Grace E. Schwartz, Laura S. Ruhl
Summary: On-site solid-waste impoundments, landfills, and receiving water bodies have been used for long-term disposal of coal combustion residuals (CCRs) in the United States. These CCRs contain various harmful components that can negatively impact ecosystems and public health. This article assesses the risks posed by CCR disposal and discusses the resilience of CCR disposal sites in the face of increasing environmental hazards. It also evaluates the current understanding of the environmental fate of CCR-derived elements and the need for improved monitoring and regulation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Cell Biology
Redouane Benabbes, Sabir Ouahhoud, Mohammed Moueqqit, Mohamed Addi, Christophe Hano, Cedric Delporte, Aminata P. Nacoulma, Veronique Megalizzi
Summary: The main objective of this study is to estimate the biological activities of total phenolics content in alcoholic extracts of date palm varieties sensitive or resistant to Fusarium oxysporum.sp Albidinis through differential analysis. Stilbene products with antioxidant and bioactive capacities were found in the resistant variety Taabdount (TAAR). Additionally, the methanolic fraction of the TAAR-resistant date palm variety contains a significant hydroxystilbene compound, which exhibits antioxidant capacities, inhibits tyrosinase activity, and protects against hypochlorite-induced damage in human dermal fibroblast aged cells. The presence of hydroxystilbene in resistant Phoenix dactylifera L. suggests its potential as an anti-aging compound.
Review
Biochemistry & Molecular Biology
Hasnat Tariq, Saaim Asif, Anisa Andleeb, Christophe Hano, Bilal Haider Abbasi
Summary: Flavonoids, a heterogeneous family of plant polyphenolic compounds, have significant bioactivity in anti-cancer, antioxidant, anti-inflammatory, and anti-microbial activities. However, traditional approaches for their production have limitations. Genetic engineering tools offer promise for exploring and scaling up production of flavonoids by modifying biosynthetic pathways in plants and microbes.
Article
Infectious Diseases
Imane Tagnaout, Hannou Zerkani, Noureddine Bencheikh, Smail Amalich, Mohamed Bouhrim, Ramzi A. Mothana, Mohammed R. Alhuzani, Rachid Bouharroud, Christophe Hano, Touriya Zair
Summary: The chemical composition of Origanum elongatum EO was analyzed, and its antioxidant, antibacterial, and insecticidal activities were evaluated. The main component of the EO was carvacrol (57.32%). The EO exhibited significant antiradical and reducing power, as well as considerable antibacterial activity against various pathogenic bacteria. It also demonstrated high efficacy as a fumigant insecticide. Therefore, O. elongatum EO could be used as a natural antioxidant, antibiotic, and biopesticide.
Article
Biochemistry & Molecular Biology
Sabir Ouahhoud, Mohamed Marghich, Hanane Makrane, Ahmed Karim, Amine Khoulati, Samira Mamri, Mohamed Addi, Christophe Hano, Redouane Benabbes, Mohammed Aziz, Abdeslam Asehraou, Ennouamane Saalaoui
Summary: The study evaluated the myorelaxant and antispasmodic activities of the byproducts (tepals and leaves) of Crocus sativus and compared them with the stigma of the plant. The results showed that the extracts had moderate myorelaxant and inhibitory effects on contractions, suggesting potential use in treating bowel spasms.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Farid Mansouri, Aymane Allay, Abdessamad Ben Moumen, Chaymae Benkirane, Yassine Taaifi, Kamal Belhaj, Mohamed Addi, Christophe Hano, Marie-Laure Fauconnier, Hana Serghini Caid, Ahmed Elamrani
Summary: The study aimed to optimize the roasting conditions of hemp seeds to improve oil yield and antioxidant capacity. Response surface methodology based on central composite design was used and showed that roasting conditions significantly affected oil yield, total phenolic content, radical scavenging activity, and oxidative stability index. The optimal conditions were determined to be roasting at 163°C for 15 minutes, which increased extraction yield by 45% and oxidative stability by 80%. The study provides valuable information for the food industry to produce hemp seed oil with high nutritional quality.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2023)
Review
Chemistry, Medicinal
Noureddine Bencheikh, Fatima Zahrae Radi, Jamila Fakchich, Amine Elbouzidi, Sabir Ouahhoud, Mohammed Ouasti, Mohamed Bouhrim, Imane Ouasti, Christophe Hano, Mostafa Elachouri
Summary: This comprehensive overview provides a summary of the botanical description and ethnobotanical uses of Ziziphus lotus, as well as the phytochemical compounds derived from it and its pharmacological and toxicological properties. The research shows that Z. lotus has traditional uses in treating and preventing various diseases, and its extracts exhibit a wide range of pharmacological activities. The phytochemical characterization of Z. lotus extracts reveals the presence of numerous bioactive compounds, and toxicity studies indicate that the extracts are safe. Further research is needed to explore the relationship between traditional uses, plant chemistry, and pharmacological properties, as well as to conduct clinical trials to determine the efficacy of Z. lotus as a medicinal agent.
Review
Chemistry, Analytical
Zahra Tariq, Muhammad Imran Qadeer, Iram Anjum, Christophe Hano, Sumaira Anjum
Summary: Thalassemia is a monogenic autosomal recessive disorder caused by mutations, which affect hemoglobin production. Conventional therapeutic methods such as transfusion and iron chelation therapy have limitations, leading to the demand for advanced therapies. Nanotechnology-based applications have emerged as simple, convenient, and cost-effective methods for theragnostics. This review summarizes the potential of nanotechnology in developing theragnostic approaches for diagnosing thalassemia-causing gene mutations and employing nano-based therapeutic procedures.
Article
Horticulture
Ahmed Marhri, Aziz Tikent, Laurine Garros, Othmane Merah, Ahmed Elamrani, Christophe Hano, Malika Abid, Mohamed Addi
Summary: The Opuntia genus, particularly the eastern Moroccan prickly pear's wild ecotype, is well-known for its high-quality fruits. However, the white cochineal poses a significant threat to the preservation of this wild prickly pear population. This study aimed to develop a rapid and efficient protocol for large-scale production of the eastern Moroccan wild ecotype using axillary buds as starting material. The results showed that the use of BAP at a concentration of 5 mg/L led to the highest regeneration of shoots, while kinetin promoted root growth and shortened the root development period. These findings have the potential to protect this botanical variety, reduce the risk of infestation, and meet the demand for superior quality fruits in the market.
Article
Engineering, Biomedical
Syeda Itrat Zahra Naqvi, Humera Kausar, Arooj Afzal, Mariam Hashim, Huma Mujahid, Maryam Javed, Christophe Hano, Sumaira Anjum
Summary: The study focuses on the protective impact of walnut-mediated silver nanoparticles (AgNPs) against Aspergillus-ochraceus-induced toxicity. It was found that the synthesized AgNPs effectively inhibited the production of toxic aflatoxins by A. ochraceus.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Plant Sciences
Muhammad Asad Ullah, Faiza Zareen Gul, Gouhar Zaman, Junaid Iqbal, Samantha Drouet, Duangjai Tungmunnithum, Christophe Hano, Bilal Haider Abbasi
Summary: In vitro shoot culture was used to induce rapid micro-propagation of Ajuga integrifolia, resulting in disease-free plantlets and high yield agitated micro-shoot cultures. The addition of Chitosan and Melatonin in a dose-dependent manner enhanced the accumulation of secondary metabolites and biomass in the micro-shoots.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Article
Biochemistry & Molecular Biology
Marta Sharafan, Magdalena Anna Malinowska, Marta Kubicz, Pawel Kubica, Marin-Pierre Gemin, Cecile Abdallah, Manon Ferrier, Christophe Hano, Nathalie Giglioli-Guivarc'h, Elzbieta Sikora, Arnaud Lanoue, Agnieszka Szopa
Summary: The primary purpose of this study was to initiate and optimize shoot cultures of different Vitis vinifera L. cultivars and investigate the influence of media and genotype on metabolic content. The use of MS media variants induced the production of certain metabolites and their antioxidant and anti-tyrosinase activities were measured. The findings suggest that in vitro cultured grapes can be a potential alternative source of plant material for the cosmetic industry.
Article
Plant Sciences
M. Derouiche, I. Mzabri, S. Ouahhoud, I. Dehmani, R. Benabess, M. Addi, C. Hano, A. Boukroute, A. Berrichi, N. Kouddane
Summary: Salinity stress limits the growth of agricultural crops and affects a vast amount of land worldwide. Aloe species, known for their cosmetic and medicinal properties, have adapted to arid conditions through CAM photosynthesis. This study investigated the effect of salinity stress on the growth and development of three Aloe plants, finding that Aloe brevifolia was the most salt-tolerant species.
Review
Oncology
Areej Shahbaz, Tehreem Mahmood, Muhammad Uzair Javed, Bilal Haider Abbasi
Summary: Microbes, with their immense metabolic capability, have complex relationships with cancer and can be used as tumor-specific infectious microorganisms in cancer therapy. However, the toxicity of traditional cancer treatments and the rise of drug resistance in tumor cells pose challenges. Alternative strategies that target tumor cells more effectively and selectively are needed. Cancer immunotherapy has greatly advanced the fight against cancer by utilizing tumor-invading immune cells and immune responses. Bacterial and viral cancer therapeutics, as promising immunotherapies, are being developed to overcome the hurdles in cancer treatment.
Review
Food Science & Technology
Salah Laaraj, Souad Salmaoui, Mohamed Addi, Chaimae El-rhouttais, Aziz Tikent, Amine Elbouzidi, Mohamed Taibi, Christophe Hano, Younes Noutfia, Kaoutar Elfazazi
Summary: Carob, a tree species native to the Mediterranean region, is known for its nutritious fruits and valuable seeds. Its seeds are rich in bioactive compounds and find applications in various industries such as food, medicine, cosmetics, and textiles.
JOURNAL OF FOOD QUALITY
(2023)
Article
Chemistry, Multidisciplinary
Hajra Ashraf, Bisma Meer, Junaid Iqbal, Joham Sarfraz Ali, Anisa Andleeb, Hira Butt, Muhammad Zia, Azra Mehmood, Muhammad Nadeem, Samantha Drouet, Jean-Philippe Blondeau, Nathalie Giglioli-Guivarc'h, Chunzhao Liu, Christophe Hano, Bilal Haider Abbasi
Summary: The goal of this study was to fabricate ZnO nanoparticles using chemical and biological routes and evaluate their physiochemical behavior and biological potentials. The synthesized nanoparticles were confirmed using spectroscopy and imaging techniques. The nanoparticles showed high antioxidant, enzyme inhibition, antibacterial, and cytotoxicity potential. The green-mediated nanoparticles exhibited superior biological potential compared to the chemically derived nanoparticles. The results suggested that these nanoparticles have promising applications in antimicrobial and cancer therapeutics.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
