Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis

Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells

(2013) Dimitry N. Krementsov et al.   ANNALS OF NEUROLOGY

HuR Is Required for IL-17-Induced Act1-Mediated CXCL1 and CXCL5 mRNA Stabilization

(2013) T. Herjan et al.   JOURNAL OF IMMUNOLOGY

The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models

(2013) D. N. Krementsov et al.   MOLECULAR AND CELLULAR BIOLOGY

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

(2011) Dongxu Sun et al.   NATURE IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

SB202190-Induced Cell Type-Specific Vacuole Formation and Defective Autophagy Do Not Depend on p38 MAP Kinase Inhibition

(2011) Manoj B. Menon et al.   PLoS One

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease

(2011) Jarod Zepp et al.   TRENDS IN IMMUNOLOGY

Signaling of interleukin-17 family cytokines in immunity and inflammation

(2010) Seon Hee Chang et al.   CELLULAR SIGNALLING

Act1, Scene Brain: Astrocytes Play a Lead Role

(2010) Jane M. Rodgers et al.   IMMUNITY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

MKP-1 Is Necessary for T Cell Activation and Function

(2009) Yongliang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-17 Signaling-Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF- 

(2009) I. Gonzalez-Garcia et al.   JOURNAL OF IMMUNOLOGY

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY