NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

(2013) B. Kwong et al.   CANCER RESEARCH

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

(2013) R. Remark et al.   CLINICAL CANCER RESEARCH

Diacylglycerol Kinases: Regulated Controllers of T Cell Activation, Function, and Development

(2013) Rohan Joshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T and NK cells: two sides of tumor immunoevasion

(2013) Doriana Fruci et al.   Journal of Translational Medicine

Diacylglycerol Kinase   Is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers

(2013) C. L. Dominguez et al.   Cancer Discovery

Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function

(2013) Sruti Krishna et al.   Frontiers in Immunology

Melanoma Cells Inhibit NK Cell Functions--Letter

(2012) G. Sconocchia et al.   CANCER RESEARCH

Strain-Specific Variation in Murine Natural Killer Gene Complex Contributes to Differences in Immunosurveillance for Urethane-Induced Lung Cancer

(2012) D. Kreisel et al.   CANCER RESEARCH

High DGK-  and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention

(2012) P. U. Prinz et al.   JOURNAL OF IMMUNOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

The three main stumbling blocks for anticancer T cells

(2012) Lukas Baitsch et al.   TRENDS IN IMMUNOLOGY

Natural killer cells in non-hematopoietic malignancies

(2012) Mélanie Desbois et al.   Frontiers in Immunology

NK cells sense tumors, course of disease and treatments

(2012) Giulia Fregni et al.   OncoImmunology

Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging

(2011) Judith Eckl et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutations of the von Hippel–Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma

(2011) A Perier et al.   ONCOGENE

Integration of Activating and Inhibitory Receptor Signaling by Regulated Phosphorylation of Vav1 in Immune Cells

(2011) S. Mesecke et al.   Science Signaling

Activation or Tolerance of Natural Killer Cells Is Modulated by Ligand Quality in a Nonmonotonic Manner

(2010) Jayajit Das   BIOPHYSICAL JOURNAL

Natural killer cells and malignant haemopathies: a model for the interaction of cancer with innate immunity

(2010) C. J. Sanchez et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Treatment of metastatic renal cell carcinoma

(2009) David J. Reeves et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE

The current role of immunotherapy for renal cell carcinoma in the era of targeted therapeutics

(2008) Michael K. K. Wong   Current Oncology Reports