A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis

A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

(2013) Yin M. Yang et al.   Cell Stem Cell

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

(2013) Merit E Cudkowicz et al.   LANCET NEUROLOGY

Improving survival in a large French ALS center cohort

(2012) Paul H. Gordon et al.   JOURNAL OF NEUROLOGY

Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model

(2012) C. Sunyach et al.   NEUROPHARMACOLOGY

Emerging targets and treatments in amyotrophic lateral sclerosis

(2011) Lorne Zinman et al.   LANCET NEUROLOGY

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis

(2011) Merit Cudkowicz et al.   NATURE MEDICINE

How can we improve clinical trials in amyotrophic lateral sclerosis?

(2011) Paul H. Gordon et al.   Nature Reviews Neurology

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis

(2011) L. M. Duffy et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

Olesoxime prevents microtubule-targeting drug neurotoxicity: Selective preservation of EB comets in differentiated neuronal cells

(2010) Amandine Rovini et al.   BIOCHEMICAL PHARMACOLOGY

The natural history of ALS is changing: Improved survival

(2009) Muddasir Qureshi et al.   Amyotrophic Lateral Sclerosis

Olesoxime (cholest-4-en-3-one, oxime): Analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel

(2009) Wen Hua Xiao et al.   PAIN

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Specific Antinociceptive Activity of Cholest-4-en-3-one, Oxime (TRO19622) in Experimental Models of Painful Diabetic and Chemotherapy-Induced Neuropathy

(2008) T. Bordet et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ALS drug development: Reflections from the past and a way forward

(2008) Swati Aggarwal et al.   Neurotherapeutics