DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B

Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

(2013) Marianna Trakala et al.   CELL CYCLE

Combination Drug Scheduling Defines a "Window of Opportunity" for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900

(2013) E. Blackwood et al.   MOLECULAR CANCER THERAPEUTICS

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Unleashing Chk1 in cancer therapy

(2011) Laura Carrassa et al.   CELL CYCLE

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

(2011) L. A. Parsels et al.   CLINICAL CANCER RESEARCH

Spindle Checkpoint Silencing: PP1 Tips the Balance

(2011) Bart Lesage et al.   CURRENT BIOLOGY

Phosphorylation at serine 331 is required for Aurora B activation

(2011) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

(2011) K. A. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

(2010) Dominic A. Sloane et al.   ACS Chemical Biology

Sds22 regulates aurora B activity and microtubule–kinetochore interactions at mitosis

(2010) Markus Posch et al.   JOURNAL OF CELL BIOLOGY

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways

(2009) Minglun Li et al.   BIOCHEMICAL PHARMACOLOGY

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45

(2008) R Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development

(2008) D. O. Cowley et al.   MOLECULAR AND CELLULAR BIOLOGY