Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

Getting away with murder: how does the BCL-2 family of proteins kill with immunity?

(2013) Thibaud T. Renault et al.   Annals of the New York Academy of Sciences

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

(2013) C. J. Vandenberg et al.   BLOOD

ABT-199: Taking Dead Aim at BCL-2

(2013) Matthew S. Davids et al.   CANCER CELL

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

(2013) Ariele Viacava Follis et al.   Nature Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells

(2012) Fenglian Xiao et al.   APOPTOSIS

Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription

(2012) Lin Feng et al.   BIOTECHNIQUES

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

(2012) B. F. Kraemer et al.   BLOOD

Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB

(2012) Junseong Park et al.   HEPATOLOGY

Critical Role for Antiapoptotic Bcl-xL and Mcl-1 in Human Macrophage Survival and Cellular IAP1/2 (cIAP1/2) in Resistance to HIV-Vpr-induced Apoptosis

(2012) Aurelia Busca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer

(2012) Matthew S. Davids et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

(2012) Susanne Herold et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Epstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders

(2012) Maria-Rosa Ghigna et al.   PATHOBIOLOGY

Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction

(2012) X. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

(2011) Chahrazade Kantari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

(2011) Konstantin H Müller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Viral subversion of immunogenic cell death

(2011) Oliver Kepp et al.   CELL CYCLE

Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: Maintenance of tight latency with efficient reactivation upon induction

(2011) Jinjong Myoung et al.   JOURNAL OF VIROLOGICAL METHODS

Infection of Lymphoblastoid Cell Lines by Kaposi's Sarcoma-Associated Herpesvirus: Critical Role of Cell-Associated Virus

(2011) J. Myoung et al.   JOURNAL OF VIROLOGY

Emerging cellular targets for influenza antiviral agents

(2011) Konstantin H. Müller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Host Immune and Apoptotic Responses to Avian Influenza Virus H9N2 in Human Tracheobronchial Epithelial Cells

(2010) Zheng Xing et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Cytosolic RNA Recognition Pathway Activates 14-3-3 Protein Mediated Signaling and Caspase-Dependent Disruption of Cytokeratin Network in Human Keratinocytes

(2010) Tiina Öhman et al.   JOURNAL OF PROTEOME RESEARCH

Caspase activation pathways: some recent progress

(2009) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Bcl-2 Expression and p38MAPK Activity in Cells Infected with Influenza A Virus

(2009) Lucia Nencioni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vesicular Stomatitis Virus Induces Apoptosis Primarily through Bak Rather than Bax by Inactivating Mcl-1 and Bcl-XL

(2009) A. F. Pearce et al.   JOURNAL OF VIROLOGY

Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

(2008) Sylvain Lebreton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH