Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

(2012) M. J. White et al.   BLOOD

The UPEC Pore-Forming Toxin α-Hemolysin Triggers Proteolysis of Host Proteins to Disrupt Cell Adhesion, Inflammatory, and Survival Pathways

(2012) Bijaya K. Dhakal et al.   Cell Host & Microbe

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

(2011) S. M. Schoenwaelder et al.   BLOOD

Central Line–Associated Bloodstream Infections: Prevention and Management

(2011) David J. Weber et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Calpain Activator Dibucaine Induces Platelet Apoptosis

(2011) Weilin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation

(2011) D. COX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets

(2011) M. T. RONDINA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombocytopenia in Staphylococcus aureus Bacteremia: Risk Factors and Prognostic Importance

(2011) Anat Gafter-Gvili et al.   MAYO CLINIC PROCEEDINGS

Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia: Estimating the Burden of Antibiotic Resistance in Europe

(2011) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Staphylococcus aureus α-Toxin Triggers the Synthesis of B-Cell Lymphoma 3 by Human Platelets

(2011) Sebastian Schubert et al.   Toxins

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

(2010) M. R. Dowling et al.   BLOOD

Cost and outcomes of nosocomial bloodstream infections complicating major traumatic injury

(2010) D.J. Niven et al.   JOURNAL OF HOSPITAL INFECTION

Bacteremia complicating gram-negative urinary tract infections: A population-based study

(2010) Majdi N. Al-Hasan et al.   JOURNAL OF INFECTION

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Platelet senescence and phosphatidylserine exposure

(2010) Swapan Kumar Dasgupta et al.   TRANSFUSION

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Myocardial Cleft, Crypt, Diverticulum, or Aneurysm? Does it Really Matter?

(2009) Luis Afonso et al.   CLINICAL CARDIOLOGY

Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia

(2009) C.-Y. CHEN et al.   EPIDEMIOLOGY AND INFECTION

Thrombocytopenia and outcome in critically ill patients with bloodstream infection

(2009) Dominique M. Vandijck et al.   HEART & LUNG

Amicus or Adversary

(2008) Fernando A. Bozza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Thrombocytopenia and Mortality in Infective Endocarditis

(2008) Raymond W. Sy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inactivation of Host Akt/Protein Kinase B Signaling by Bacterial Pore-forming Toxins

(2008) Travis J. Wiles et al.   MOLECULAR BIOLOGY OF THE CELL