A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5

A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and Human Receptors

(2014) Hyekyung P. Cho et al.   ACS Chemical Neuroscience

Therapeutic potential of targeting glutamate receptors in Parkinson’s disease

(2014) Clare Finlay et al.   JOURNAL OF NEURAL TRANSMISSION

Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

(2014) Simona D’Antoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The metabotropic glutamate receptors: Potential drug targets for the treatment of anxiety disorders?

(2013) Nikolaos Pitsikas   EUROPEAN JOURNAL OF PHARMACOLOGY

mGlu5negative allosteric modulators: a patent review (2010 – 2012)

(2013) Kyle A Emmitte   EXPERT OPINION ON THERAPEUTIC PATENTS

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254)

(2013) Mark Turlington et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor

(2013) B. Vilar et al.   JOURNAL OF NEUROSCIENCE

Development of allosteric modulators of GPCRs for treatment of CNS disorders

(2013) Hilary Highfield Nickols et al.   NEUROBIOLOGY OF DISEASE

Metabotropic glutamatergic receptors and their ligands in drug addiction

(2013) Lucyna Pomierny-Chamioło et al.   PHARMACOLOGY & THERAPEUTICS

Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators

(2012) Birgitte H. Kaae et al.   ChemMedChem

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

(2012) Cyril Goudet et al.   FASEB JOURNAL

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

(2012) Filippo Caraci et al.   NEUROCHEMISTRY INTERNATIONAL

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease

(2012) M. Amalric et al.   NEUROPHARMACOLOGY

Recent Advances in the Design and Development of Novel Negative Allosteric Modulators of mGlu5

(2011) Kyle A. Emmitte   ACS Chemical Neuroscience

Progress toward Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 (mGlu5)

(2011) Shaun R. Stauffer   ACS Chemical Neuroscience

Recent Progress on the Identification of Metabotropic Glutamate 4 Receptor Ligands and Their Potential Utility as CNS Therapeutics

(2011) Albert J. Robichaud et al.   ACS Chemical Neuroscience

“Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

(2011) Michael R. Wood et al.   BIOCHEMISTRY

Efficacy switching SAR of mGluR5 allosteric modulators: Highly potent positive and negative modulators from one chemotype

(2011) Anette Graven Sams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery, Synthesis, and Structure−Activity Relationship Development of a Series ofN-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats

(2011) Darren W. Engers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, Synthesis, and Structure–Activity Relationship Development of a Series ofN-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model

(2011) Carrie K. Jones et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)

(2009) Darren W. Engers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS