- Home
- Publications
- Publication Search
- Publication Details
Title
mGlu5negative allosteric modulators: a patent review (2010 – 2012)
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 23, Issue 4, Pages 393-408
Publisher
Informa Healthcare
Online
2013-01-23
DOI
10.1517/13543776.2013.760544
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The effects of a novel metabotropic glutamate receptor 5 antagonist (AZD2066) on transient lower oesophageal sphincter relaxations and reflux episodes in healthy volunteers
- (2012) W. O. Rohof et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development
- (2012) Patrick Raboisson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents
- (2012) Jean-Philippe Rocher et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
- (2012) Aubin Michalon et al. NEURON
- Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism
- (2012) J. L. Silverman et al. Science Translational Medicine
- Recent Advances in the Design and Development of Novel Negative Allosteric Modulators of mGlu5
- (2011) Kyle A. Emmitte ACS Chemical Neuroscience
- Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery
- (2011) Bruce J. Melancon et al. JOURNAL OF MEDICINAL CHEMISTRY
- AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials
- (2011) Daniela Berg et al. MOVEMENT DISORDERS
- The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in l-Dopa-treated parkinsonian monkeys
- (2011) Laurent Grégoire et al. PARKINSONISM & RELATED DISORDERS
- Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome
- (2011) Alexia M. Thomas et al. PSYCHOPHARMACOLOGY
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors
- (2010) CL Adams et al. BRITISH JOURNAL OF PHARMACOLOGY
- Glutamate receptors in pediatric tumors of the central nervous system
- (2010) Katja S. Brocke et al. CANCER BIOLOGY & THERAPY
- Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?
- (2010) Juana CA Marin et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5
- (2010) Douglas F. Burdi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys
- (2010) Nicolas Morin et al. NEUROPHARMACOLOGY
- The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine
- (2010) Valeria Tronci et al. PSYCHOPHARMACOLOGY
- Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
- (2009) Vidhya Kumaresan et al. BEHAVIOURAL BRAIN RESEARCH
- A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease
- (2009) C Keywood et al. GUT
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
- Interoceptive Effects of Alcohol Require mGlu5 Receptor Activity in the Nucleus Accumbens
- (2009) J. Besheer et al. JOURNAL OF NEUROSCIENCE
- Dissociation of the Effects of MTEP [3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on Conditioned Reinstatement and Reinforcement: Comparison between Cocaine and a Conventional Reinforcer
- (2009) R. Martin-Fardon et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP
- (2009) Jill L Silverman et al. NEUROPSYCHOPHARMACOLOGY
- Role of protein kinase C epsilon (PKCɛ) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell
- (2009) Justin T. Gass et al. PSYCHOPHARMACOLOGY
- G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms
- (2008) Thomas M. Bridges et al. ACS Chemical Biology
- mGlu5 receptor antagonists and their therapeutic potential
- (2008) Georg Jaeschke et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B Inhibitors
- (2008) Lourdes Santana et al. JOURNAL OF MEDICINAL CHEMISTRY
- Continuous and Intermittent Nicotine Treatment Reduces L-3,4-Dihydroxyphenylalanine (L-DOPA)-Induced Dyskinesias in a Rat Model of Parkinson's Disease
- (2008) T. Bordia et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
- (2008) P. Jeffrey Conn et al. NATURE REVIEWS DRUG DISCOVERY
- Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
- (2008) Femke M.S. de Vrij et al. NEUROBIOLOGY OF DISEASE
- Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP
- (2008) Jason P. Schroeder et al. NEUROPHARMACOLOGY
- mGluR5 Antagonism Attenuates Methamphetamine Reinforcement and Prevents Reinstatement of Methamphetamine-Seeking Behavior in Rats
- (2008) Justin T Gass et al. NEUROPSYCHOPHARMACOLOGY
- Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
- (2008) Donna M. Platt et al. PSYCHOPHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More