The use of phosphate bioisosteres in medicinal chemistry and chemical biology

Photoactivatable and Cell-Membrane-Permeable Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Matthias Mentel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Boron-containing inhibitors of synthetases

(2011) Stephen J. Baker et al.   CHEMICAL SOCIETY REVIEWS

Squaramides: physical properties, synthesis and applications

(2011) R. Ian Storer et al.   CHEMICAL SOCIETY REVIEWS

Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

(2011) Piotr Guga et al.   CHEMISTRY & BIODIVERSITY

Metabolically Stabilized Derivatives of Phosphatidylinositol 4-Phosphate: Synthesis and Applications

(2011) Ju He et al.   CHEMISTRY & BIOLOGY

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

(2011) Go Hirai et al.   ChemMedChem

Boranophosphate Isoster Controls P2Y-Receptor Subtype Selectivity and Metabolic Stability of Dinucleoside Polyphosphate Analogues

(2011) Shir Yelovitch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin

(2011) Harald M. H. G. Albers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

(2011) Hiroshi Nishimasu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration

(2010) Honglu Zhang et al.   CHEMBIOCHEM

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

(2010) Neil S. Keddie et al.   CHEMICAL COMMUNICATIONS

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin

(2010) Harald M. H. G. Albers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diadenosine 5′,5′′-(Boranated)polyphosphonate Analogues as Selective Nucleotide Pyrophosphatase/Phosphodiesterase Inhibitors⊥

(2010) Shay Eliahu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: Structure, synthesis, and development of probes for studying biological activity

(2010) Michael D. Best et al.   NATURAL PRODUCT REPORTS

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells

(2010) Devaraj Subramanian et al.   Nature Chemical Biology

Why did Nature select phosphate for its dominant roles in biology?

(2010) Matthew W. Bowler et al.   NEW JOURNAL OF CHEMISTRY

Rationally designed squaryldiamides – a novel class of sugar-nucleotide mimics?

(2010) Sven Niewiadomski et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 4′-aminopantetheine and derivatives to probe aminoglycoside N-6′-acetyltransferase

(2010) Xuxu Yan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthesis of dioctanoyl phosphatidylinositol

(2010) Thomas S. Elliott et al.   TETRAHEDRON-ASYMMETRY

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP

(2009) Anthony R. Martin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

(2009) Stuart J. Conway et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function

(2009) Thomas G. Upton et al.   ORGANIC LETTERS

A type 2 Ferrier rearrangement-based synthesis of d-myo-inositol 1,4,5-trisphosphate

(2009) Neil S. Keddie et al.   TETRAHEDRON-ASYMMETRY

Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer

(2008) G PRESTWICH   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition

(2008) Munawar Hussain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tetramic and tetronic acids: An update on new derivatives and biological aspects

(2008) Rainer Schobert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold

(2008) Christopher P. Holmes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Borononucleotides: synthesis, and formation of a new reversible boronate internucleosidic linkage

(2008) Delphine Luvino et al.   CHEMICAL COMMUNICATIONS

Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria

(2008) Kimberly D. Grimes et al.   ChemMedChem

Seleninate in Place of Phosphate: Irreversible Inhibition of Protein Tyrosine Phosphatases

(2008) Mohannad Abdo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate

(2007) Honglu Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

(2007) Brent Douty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS