Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 1, Pages 242-244Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03003a
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Funding
- University of St Andrews
- BBSRC
- St Hugh's College, Oxford
- Biotechnology and Biological Sciences Research Council [BB/C515255/1] Funding Source: researchfish
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The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.
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