Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

Antisense drug discovery and development

(2011) Tsuyoshi Yamamoto et al.   Future Medicinal Chemistry

DNA phosphorothioation is widespread and quantized in bacterial genomes

(2011) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligonucleotide N3′→P5′ Phosphoramidates andThio-Phoshoramidates as Potential Therapeutic Agents

(2010) Sergei M. Gryaznov   CHEMISTRY & BIODIVERSITY

Diastereomerically pure nucleoside-5′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s-Substrates for synthesis of P-chiral derivatives of nucleoside-5′-O-phosphorothioates

(2010) Agnieszka Tomaszewska et al.   CHIRALITY

Designing highly active siRNAs for therapeutic applications

(2010) S. Patrick Walton et al.   FEBS Journal

Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5′-O-Phosphorothioates to Nucleoside 5′-O-Phosphates

(2010) Magdalena Ozga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxyalkylated phosphoramidate, phosphoramidothioate and phosphorodiamidothioate derivatives as thiophosphate protecting groups in the development of thermolytic DNA prodrugs

(2010) Andrzej Grajkowski et al.   NEW JOURNAL OF CHEMISTRY

Sulfur as a mechanistic probe in enzymatic and non-enzymatic substitution at phosphorus

(2010) Perry A. Frey   NEW JOURNAL OF CHEMISTRY

Automated synthesis of phosphorus–sulfur analogs of nucleic acids—25 years on: potential therapeutic agents and proven utility in biotechnology

(2010) Gerald Zon   NEW JOURNAL OF CHEMISTRY

Synthesis of nucleoside and oligonucleoside dithiophosphates

(2010) Xianbin Yang et al.   NEW JOURNAL OF CHEMISTRY

Why did Nature select phosphate for its dominant roles in biology?

(2010) Matthew W. Bowler et al.   NEW JOURNAL OF CHEMISTRY

Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

(2010) Andrzej Guranowski et al.   NEW JOURNAL OF CHEMISTRY

Stereopure oligonucleotide phosphorothioates as human telomerase substrates

(2010) Ronald Pruzan et al.   NEW JOURNAL OF CHEMISTRY

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

(2010) Jacek Jemielity et al.   NEW JOURNAL OF CHEMISTRY

A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella

(2010) Tiegang Xu et al.   NUCLEIC ACIDS RESEARCH

Stereoselective formation of a P–P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates

(2010) Damian Błaziak et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

RNAi and small interfering RNAs in human disease therapeutic applications

(2010) Monica R. Lares et al.   TRENDS IN BIOTECHNOLOGY

Twenty years hunting for sulfur in DNA

(2010) Shi Chen et al.   Protein & Cell

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

(2009) Joanna Kowalska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNA phosphorothioation in Streptomyces lividans: mutational analysis of the dnd locus

(2009) Tiegang Xu et al.   BMC MICROBIOLOGY

Chemical Modification of Oligonucleotides for Therapeutic, Bioanalytical and other Applications

(2009) Neil M. Bell et al.   CHEMBIOCHEM

Functional analysis ofspfDgene involved in DNA phosphorothioation inPseudomonas fluorescensPf0-1

(2009) Fen Yao et al.   FEBS LETTERS

Prospects of antisense therapy technologies

(2009) M. Yu. Skoblov   MOLECULAR BIOLOGY

Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells

(2009) Qian Chen Yong et al.   NEUROCHEMISTRY INTERNATIONAL

Hydrogen sulfide: A novel signaling molecule in the central nervous system

(2009) Boon Hian Tan et al.   NEUROCHEMISTRY INTERNATIONAL

Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

(2009) Natsuhisa Oka et al.   ORGANIC LETTERS

Protecting of a Thermolabile Protecting Group: “Click-Clack” Approach

(2009) Marcin K. Chmielewski   ORGANIC LETTERS

Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

(2009) Cristina Ausín et al.   TETRAHEDRON

Stereocontrolled Solid-Phase Synthesis of OligonucleosideH-Phosphonates by an Oxazaphospholidine Approach

(2008) Naoki Iwamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-β1 protein

(2008) Jonghoon Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of RP and SPPhosphorothioate Substitution at the Scissile Site on the Cleavage Activity of Deoxyribozyme 10-23

(2008) Barbara Nawrot et al.   CURRENT ORGANIC CHEMISTRY

Phosphorothioate-Stimulated Cellular Uptake of siRNA: A Cell Culture Model for Mechanistic Studies

(2008) A. Detzer et al.   CURRENT PHARMACEUTICAL DESIGN

Solid-Phase Synthesis of Stereoregular Oligodeoxyribonucleoside Phosphorothioates Using Bicyclic Oxazaphospholidine Derivatives as Monomer Units

(2008) Natsuhisa Oka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Significance of Stereochemistry of 3′-Terminal Phosphorothioate-modified Primer in DNA Polymerase-mediated Chain Extension

(2008) Barbara Nawrot et al.   MOLECULAR BIOTECHNOLOGY

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

(2008) J. Kowalska et al.   RNA

Telomerase targeted oligonucleotidethio-phosphoramidates in T24-luc bladder cancer cells

(2007) Z. Gunnur Dikmen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY