Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

Addressing MIST (Metabolites in Safety Testing): Bioanalytical Approaches to Address Metabolite Exposures in Humans and Animals

(2013) Hongying Gao et al.   CURRENT DRUG METABOLISM

Quantitative estimation of circulating metabolites without synthetic standards by ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction

(2011) Yanou Yang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

From definition to implementation: a cross-industry perspective of past, current and future MIST strategies

(2011) Angus N.R. Nedderman et al.   XENOBIOTICA

The Concept of Spectral Accuracy for MS

(2010) Yongdong Wang et al.   ANALYTICAL CHEMISTRY

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

(2010) Ping Yi et al.   Bioanalysis

Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

(2010) Angus NR Nedderman et al.   Bioanalysis

Novel MS solutions inspired by MIST

(2010) Ragu Ramanathan et al.   Bioanalysis

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Spectral accuracy of molecular ions in an LTQ/Orbitrap mass spectrometer and implications for elemental composition determination

(2009) John C. L. Erve et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

(2008) Filip Cuyckens et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

(2008) Bente Gammelgaard et al.   Expert Opinion on Drug Metabolism & Toxicology

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

(2008) Filip Cuyckens et al.   JOURNAL OF CHROMATOGRAPHY A

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a ‘first-line’ approach for metabolite identification studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

(2008) Filip Cuyckens et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection

(2007) Qian Ruan et al.   JOURNAL OF MASS SPECTROMETRY