Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

(2010) Kenny De Wolf et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

(2010) Jon S.B. de Vlieger et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations

(2009) Mingshe Zhu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Metabolites in safety testing: metabolite identification strategies in discovery and development

(2009) Angus N. R. Nedderman   BIOPHARMACEUTICS & DRUG DISPOSITION

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interpretation and Considerations on the Safety Evaluation of Human Drug Metabolites

(2009) Aisar H. Atrakchi   CHEMICAL RESEARCH IN TOXICOLOGY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

(2009) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium

(2009) Kayoko Tahara et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Can density functional theory (DFT) be used as an aid to a deeper understanding of tandem mass spectrometric fragmentation pathways?

(2009) Alexander Alex et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metabolites in safety testing

(2009) Timothy W Robison et al.   Bioanalysis

Metabolite quantitation: detector technology and MIST implications

(2009) Pat Wright et al.   Bioanalysis

IMS/MS: its time has come

(2008) Rajendrani Mukhopadhyay   ANALYTICAL CHEMISTRY

Determinants for Optimal Enhancement in Ex Situ DNP Experiments

(2008) A.-H. Emwas et al.   APPLIED MAGNETIC RESONANCE

Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects

(2008) Samantha Abel et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery

(2008) Chandra Prakash et al.   CURRENT DRUG METABOLISM

Contribution of the N-Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans

(2008) S. Klieber et al.   DRUG METABOLISM AND DISPOSITION

Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR

(2008) T. Johansson et al.   DRUG METABOLISM AND DISPOSITION

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

(2008) Bente Gammelgaard et al.   Expert Opinion on Drug Metabolism & Toxicology

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Parahydrogen induced polarization of barbituric acid derivatives:1H hyperpolarization studies

(2008) Meike Roth et al.   MAGNETIC RESONANCE IN CHEMISTRY

Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates

(2008) Bernardin Akagah et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Quantitative metabolomics using NMR

(2008) David S. Wishart   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Applications of Metabolomics in Drug Discovery and Development

(2008) David S Wishart   Drugs in research & development

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY