Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof

The effect of dichloroacetate in mouse models of epilepsy

(2018) Dylan Durie et al.   EPILEPSY RESEARCH

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

(2018) Kah Ni Tan et al.   JOURNAL OF NEUROCHEMISTRY

Seizure-induced reduction in glucose utilization promotes brain hypometabolism during epileptogenesis

(2018) Anton Malkov et al.   NEUROBIOLOGY OF DISEASE

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy

(2018) Sophie Calvert et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

(2017) Tanya S. McDonald et al.   EPILEPSIA

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species

(2017) Stjepana Kovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

(2017) Ajit S. Divakaruni et al.   JOURNAL OF CELL BIOLOGY

Triheptanoin versus trioctanoin for long-chain fatty acid oxidation disorders: a double blinded, randomized controlled trial

(2017) Melanie B. Gillingham et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction

(2017) Yuri Zilberter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic inhibition of brain glycolysis initiates epileptogenesis

(2017) Evgeniya Samokhina et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy

(2017) Yuankai Zhu et al.   JOURNAL OF NUCLEAR MEDICINE

UX007 for the treatment of long chain-fatty acid oxidation disorders: Safety and efficacy in children and adults following 24 weeks of treatment

(2017) J. Vockley et al.   MOLECULAR GENETICS AND METABOLISM

Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models

(2017) I. Popova et al.   NEUROBIOLOGY OF DISEASE

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

(2016) Kah Ni Tan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Seizure control by decanoic acid through direct AMPA receptor inhibition

(2015) Pishan Chang et al.   BRAIN

The Utility of Positron Emission Tomography in Epilepsy

(2015) Jorge G. Burneo et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

Non-signalling energy use in the brain

(2015) Elisabeth Engl et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15years Experience

(2015) Charles R. Roe et al.   MOLECULAR GENETICS AND METABOLISM

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13C NMR Data

(2014) Puneet Bagga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain

(2014) Yifan Zhang et al.   JOURNAL OF NEUROCHEMISTRY

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate synthesis has to be matched by its degradation - where do all the carbons go?

(2014) Ursula Sonnewald   JOURNAL OF NEUROCHEMISTRY

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

(2014) Nathaniel M. Vacanti et al.   MOLECULAR CELL

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

(2014) Dan Shao et al.   Nature Communications

Citric Acid Cycle and Role of its Intermediates in Metabolism

(2013) Muhammad Akram   CELL BIOCHEMISTRY AND BIOPHYSICS

Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

(2013) Kristina A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

(2013) Shane Rowley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ketosis Proportionately Spares Glucose Utilization in Brain

(2013) Yifan Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Mitochondrial Metabolic Dysfunction and Glutamate Level Reduction in the Pilocarpine Model of Temporal Lobe Epilepsy in Mice

(2013) Olav B Smeland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alterations of Hippocampal Glucose Metabolism by Even versus Uneven Medium Chain Triglycerides

(2013) Tanya S McDonald et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

(2013) Mussie G. Hadera et al.   JOURNAL OF NEUROCHEMISTRY

Triheptanoin in acute mouse seizure models

(2012) Nicola K. Thomas et al.   EPILEPSY RESEARCH

Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

(2012) Tae Hwan Kim et al.   EPILEPSY RESEARCH

Synthesis of triheptanoin and formulation as a solid diet for rodents

(2012) Vladislav Semak et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

(2012) S. Kovac et al.   JOURNAL OF CELL SCIENCE

Heptanoate as a Neural Fuel: Energetic and Neurotransmitter Precursors in Normal and Glucose Transporter I-Deficient (G1D) Brain

(2012) Isaac Marin-Valencia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

(2012) Olav B. Smeland et al.   NEUROCHEMISTRY INTERNATIONAL

Energy depletion in seizures: Anaplerosis as a strategy for future therapies

(2012) Stjepana Kovac et al.   NEUROPHARMACOLOGY

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene

(2011) Yasutoshi Koga et al.   BRAIN & DEVELOPMENT

α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

(2010) Aaron L. McLain et al.   FREE RADICAL RESEARCH

The protein family of glucose transport facilitators: It's not only about glucose after all

(2010) Robert Augustin   IUBMB LIFE

Direct Measurement of Extracellular Lactate in the Human Hippocampus During Spontaneous Seizures

(2010) Matthew J. During et al.   JOURNAL OF NEUROCHEMISTRY

Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

(2010) C. M. Dube et al.   JOURNAL OF NEUROSCIENCE

Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways

(2010) Charles R. Roe et al.   MOLECULAR GENETICS AND METABOLISM

Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models

(2010) Sarah Willis et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

(2010) Andrezza Sossai Rodrigues Carvalho et al.   NEUROCHEMISTRY INTERNATIONAL

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Monitoring phosphorylation of the pyruvate dehydrogenase complex

(2009) Matthew J. Rardin et al.   ANALYTICAL BIOCHEMISTRY

Dipropionylcysteine Ethyl Ester Compensates for Loss of Citric Acid Cycle Intermediates During Post Ischemia Reperfusion in the Pig Heart

(2009) Takhar Kasumov et al.   CARDIOVASCULAR DRUGS AND THERAPY

Interrelations between C4Ketogenesis, C5Ketogenesis, and Anaplerosis in the Perfused Rat Liver

(2009) Shuang Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain

(2009) D. Ballhausen et al.   NEUROSCIENCE

ATP and fructose‐2,6‐bisphosphate regulate skeletal muscle 6‐phosphofructo‐1‐kinase by altering its quaternary structure

(2008) Patricia Zancan et al.   IUBMB LIFE

Neuroprotection in Diet-Induced Ketotic Rat Brain after Focal Ischemia

(2008) Michelle A Puchowicz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Carnitine palmitoyltransferase II deficiency: Successful anaplerotic diet therapy

(2008) C. R. Roe et al.   NEUROLOGY