Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?

Functional Adaptation of Nef to the Immune Milieu of HIV-1 Infection In Vivo

(2014) M. J. Lewis et al.   JOURNAL OF IMMUNOLOGY

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

(2014) T. Ueno et al.   JOURNAL OF IMMUNOLOGY

Genetic and Functional Analysis of HIV Type 1 nef Gene Derived from Long-Term Nonprogressor Children: Association of Attenuated Variants with Slow Progression to Pediatric AIDS

(2012) Guillermo Corró et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes

(2012) D. Y. Chen et al.   BLOOD

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

(2012) Paul J. McLaren et al.   HUMAN MOLECULAR GENETICS

Targets for Inhibition of HIV Replication: Entry, Enzyme Action, Release and Maturation

(2012) Saleta Sierra et al.   INTERVIROLOGY

Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo

(2012) M. J. Lewis et al.   JOURNAL OF VIROLOGY

Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

(2012) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation

(2012) U. S. Rajapaksa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

(2012) Lillian S Kuo et al.   Retrovirology

Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China

(2011) T. Dong et al.   BLOOD

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

(2011) Alessia Landi et al.   CURRENT HIV RESEARCH

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

(2011) John L. Foster et al.   Journal of Neuroimmune Pharmacology

HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

(2011) J. A. Leonard et al.   JOURNAL OF VIROLOGY

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages

(2011) Philip Mwimanzi et al.   Retrovirology

Antiretroviral Therapy as HIV Prevention: Status and Prospects

(2010) Kenneth H. Mayer et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection

(2010) Philip Mwimanzi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of mucosal CD4 lymphocytes is an early feature of HIV infection

(2010) S. G. LIM et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The synapse and cytolytic machinery of cytotoxic T cells

(2010) Misty R Jenkins et al.   CURRENT OPINION IN IMMUNOLOGY

Viral evasion of T cell immunity: ancient mechanisms offering new applications

(2010) Daniëlle Horst et al.   CURRENT OPINION IN IMMUNOLOGY

HIV-1 Nef Binds a Subpopulation of MHC-I throughout Its Trafficking Itinerary and Down-regulates MHC-I by Perturbing Both Anterograde and Retrograde Trafficking

(2010) Ling Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression

(2010) R. Pushker et al.   JOURNAL OF VIROLOGY

High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

(2010) T. C. Friedrich et al.   JOURNAL OF VIROLOGY

Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study

(2010) Julio SG Montaner et al.   LANCET

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells

(2010) Joseph K. Wong et al.   PLoS Pathogens

A Basic Patch on  -Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex

(2009) R. Chaudhuri et al.   JOURNAL OF VIROLOGY

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

(2009) Zabrina L. Brumme et al.   PLoS One

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

(2009) Rajendra Kumar Singh et al.   PLoS One

HIV-1 Nef protein: Purification, crystallizations, and preliminary X-ray diffraction studies

(2009) P. Franken et al.   PROTEIN SCIENCE

Common Genetic Variation and the Control of HIV-1 in Humans

(2009) Jacques Fellay et al.   PLoS Genetics

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

Role of Nef in primate lentiviral immunopathogenesis

(2008) F. Kirchhoff et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Strategies for Inhibiting Function of HIV-1 Accessory Proteins: A Necessary Route to AIDS Therapy?

(2008) S. Richter et al.   CURRENT MEDICINAL CHEMISTRY

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

(2008) Sophie Limou et al.   JOURNAL OF INFECTIOUS DISEASES

Functional Characterization of the Human Immunodeficiency Virus Type 1 Nef Acidic Domain

(2008) L. L. Baugh et al.   JOURNAL OF VIROLOGY

Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection

(2008) Z. L. Brumme et al.   JOURNAL OF VIROLOGY

HIV evolution in response to HLA-restricted CTL selection pressures: a population-based perspective

(2008) Jonathan M. Carlson et al.   MICROBES AND INFECTION

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens