Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human

Practical use of the regression offset approach for the prediction ofin vivointrinsic clearance from hepatocytes

(2012) Anna-Karin Sohlenius-Sternbeck et al.   XENOBIOTICA

Predicting Drug – Drug Interactions Involving the Inhibition of Intestinal CYP3A4 and P-Glycoprotein

(2011) Tatsuhiko Tachibana et al.   CURRENT DRUG METABOLISM

PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism

(2011) Jianghong Fan et al.   CURRENT DRUG METABOLISM

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

(2011) A. S. Darwich et al.   CURRENT DRUG METABOLISM

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

(2011) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Intestinal First-pass Metabolism of CYP3A and UGT Substrates in Humans from in vitro Data

(2011) Haruka Nishimuta et al.   Drug Metabolism and Pharmacokinetics

In vitroandin vivosmall intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

(2011) Hiroshi Komura et al.   DRUG METABOLISM REVIEWS

High-throughput analysis of standardized pharmacokinetic studies in the rat using sample pooling and UPLC–MS/MS

(2011) Tjerk Bueters et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative Prediction of Intestinal Metabolism in Humans from a Simplified Intestinal Availability Model and Empirical Scaling Factor

(2010) K. Kadono et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic Interaction between JBP485 and Cephalexin in Rats

(2010) J. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

(2010) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

(2010) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

(2010) A.-K. Sohlenius-Sternbeck et al.   XENOBIOTICA

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery

(2009) Amin A. Nomeir et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans

(2009) Masayuki Takahashi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

(2008) Aleksandra Galetin et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacokinetics of tramadol in rat plasma and cerebrospinal fluid after intranasal administration

(2008) Yan Zhao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone

(2007) Anooshirvan Shayeganpour et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

EFFECTS OF LIVER FIBROSIS ON VERAPAMIL PHARMACOKINETICS IN RATS

(2007) Man Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY