Article
Pharmacology & Pharmacy
Ji-Sang Lee, Hyo-Sung Kim, Yong-Seob Jung, Hyeon-Gyeom Choi, So-Hee Kim
Summary: In rats, co-administration of voriconazole and tofacitinib resulted in significantly increased AUC and slower CLNR of tofacitinib, attributed to non-competitive inhibition of tofacitinib metabolism by voriconazole via CYP3A1/2 and CYP2C11. Pharmacokinetics of voriconazole remained unaffected by the presence of tofacitinib.
Article
Biochemistry & Molecular Biology
Yanjun Cui, Ying Li, Caihui Guo, Yajing Li, Yinling Ma, Zhanjun Dong
Summary: This study investigated the pharmacokinetic drug interactions between canagliflozin and sorafenib or lenvatinib and found significant changes in the plasma concentrations and apparent clearance of these drugs. These findings provide a reference for the use of canagliflozin, sorafenib and lenvatinib in patients with HCC and T2DM.
Article
Plant Sciences
Qiangjun Chen, Changlong Yin, Yongwei Li, Zhe Yang, Zongying Tian
Summary: The combination of peimine and paeoniflorin can increase the systemic exposure of paeoniflorin by inhibiting the activity of CYP3A4 and P-gp. Peimine also affects the metabolic stability and transportation of paeoniflorin. This study provides a reference for further in vivo studies involving a broader population.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Plant Sciences
Yongpeng Wang, Ruping Rui, Xiaoyan Zhang, Bin Sun
Summary: The study reveals that succinic acid increases the exposure of irbesartan by inhibiting CYP2C9, leading to prolonged half-life of irbesartan. Additionally, succinic acid affects the metabolic stability of irbesartan.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xueru He, Ying Li, Yajing Li, Caihui Guo, Yuhao Fu, Xuejiao Xun, Zhi Wang, Zhanjun Dong
Summary: This study aimed to evaluate the pharmacokinetic interactions between Donafenib and Dapagliflozin as well as Canagliflozin, and explore the potential mechanisms. The results showed that Dapagliflozin and Canagliflozin increased the plasma concentration of Donafenib, while Donafenib also affected the pharmacokinetics of Dapagliflozin and Canagliflozin. These interactions may be clinically significant.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Suili Yang, Xiaoshan Zhang, Yuzhen Wang, Congcong Wen, Chenxiang Wang, Ziye Zhou, Guanyang Lin
Summary: A bioanalytical method was developed to study the potential interaction between dasatinib and posaconazole, demonstrating that dasatinib alters the pharmacokinetics of posaconazole. When co-administered, attention should be paid to the unexpected risk of adverse clinical outcomes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Agnieszka Karbownik, Danuta Szkutnik-Fiedler, Tomasz Grabowski, Anna Wolc, Joanna Stanislawiak-Rudowicz, Radoslaw Jazwiec, Edmund Grzeskowiak, Edyta Szalek
Summary: This study evaluated the potential pharmacokinetic drug-drug interactions between sorafenib and morphine, finding that morphine significantly increased plasma concentrations of sorafenib and its active metabolite, while sorafenib significantly increased the exposure to morphine and its metabolite, indicating potential clinical significance in cancer therapy with both improved response and increased risk of adverse effects.
Article
Pharmacology & Pharmacy
Dong Kyun Kim, Soo Yong Chung, Jae-Hwan Kwak, Min-Soo Kim, Christine E. Staatz, Hye Suk Lee, In-Hwan Baek
Summary: The co-administration of dronedarone and ticagrelor in rats led to significant changes in their pharmacokinetic parameters, indicating a potential interaction between the two drugs. Further investigation in humans is warranted to assess the implications of simultaneous use of dronedarone and ticagrelor.
Article
Plant Sciences
Ya-nan Liu, Jie Chen, Xinhao Xu, Yingying Hu, Jin-yu Hu, Ren-ai Xu, Guanyang Lin
Summary: This study establishes a method for determining the concentration of derazantinib in rat plasma and investigates the drug-drug interaction between derazantinib and naringin. The results suggest that the metabolism of derazantinib is not significantly affected by naringin, allowing for their safe concomitant administration.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Infectious Diseases
T. Goulenok, J. Seurat, A. de La Selle, V. Jullien, V. Leflon-Guibout, N. Grall, F. X. Lescure, R. Lepeule, J. Bertrand, B. Fantin, C. Burdet, A. Lefort
Summary: The study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) interaction between rifampicin and clindamycin in the treatment of staphylococcal osteoarticular infection (SOAI). Results showed that co-administration of rifampicin significantly increased clindamycin clearance and decreased the probability of reaching PK/PD targets. These findings suggest that the use of rifampicin in combination with clindamycin may result in clinical failure, even for fully susceptible strains.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biology
Mohammed Asad, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Abdullah Ali Al Mushtawi, Assil Najib Alajmi, Hanan Nageeb Alajmi, Mohd. Imran, Raha Orfali
Summary: The study found that guggulipid extract can increase the bioavailability of Rosuvastatin calcium (RC) and enhance its lipid-lowering effect. However, it is recommended to determine the potential adverse effects of using a combination of RC and guggulipid extract before administration.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yuan Xu, Jian Lu, Bingyi Yao, Yuanjin Zhang, Shengbo Huang, Jie Liu, Yanfang Zhang, Yuanqing Guo, Xin Wang
Summary: The combination of fluoxetine and olanzapine significantly increased the plasma concentration of olanzapine, decreased its clearance, and increased tissue exposure in rats, indicating a potential drug-drug interaction. However, in gene knockout rats, the combination did not show similar effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Plant Sciences
Xizi Liu, Shiyi Han, Qian Yang, Siyang Fan
Summary: This study investigated the pharmacokinetic and pharmacodynamic mechanism of the interaction between GAD and BBR. The results showed that GAD had significant effects on the PK interaction and regulation of drug-metabolizing enzymes.
Article
Plant Sciences
Xizi Liu, Shiyi Han, Qian Yang, Siyang Fan
Summary: The study demonstrated that the combination of GAD and BBR enhanced the efficacy of BBR and provided insights into the pharmacokinetic mechanisms of the interaction between these two substances, showing a potential synergistic effect from the PK interaction partially mediated by CYP2C11(9) and enterohepatic recycling.
Article
Plant Sciences
Jie Zhang, Lu Liu, Hong Li, Bin Zhang
Summary: The co-administration of pachymic acid and bavachin resulted in altered pharmacokinetic profiles of bavachin, including increased AUC, prolonged half-life, and decreased clearance in vivo. Pachymic acid enhanced the metabolic stability of bavachin while inhibiting its transport. Furthermore, pachymic acid was found to inhibit the activity of CYP2C9.
PHARMACEUTICAL BIOLOGY
(2021)