Practical use of the regression offset approach for the prediction ofin vivointrinsic clearance from hepatocytes

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

(2010) A.-K. Sohlenius-Sternbeck et al.   XENOBIOTICA

Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug−Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry

(2009) Mathew G. Soars et al.   MOLECULAR PHARMACEUTICS

Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes

(2009) E. Floby et al.   XENOBIOTICA

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

(2008) Kuresh A. Youdim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

(2008) S. W. Paine et al.   DRUG METABOLISM AND DISPOSITION

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

Prediction of drug distribution within blood

(2008) Paulo Paixão et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Determination of microsome and hepatocyte scaling factors forin vitro/in vivoextrapolation in the rat and dog

(2008) R. Smith et al.   XENOBIOTICA

Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines

(2008) D. Hallifax et al.   XENOBIOTICA

Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance

(2008) R. Stringer et al.   XENOBIOTICA