Review
Pharmacology & Pharmacy
Anna Licata, Maria Giovanna Minissale, Simona Stankeviciute, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J. Andrade, Piero Luigi Almasio
Summary: N-acetylcysteine (NAC) is an effective therapeutic option for acetaminophen (APAP) overdose, improving hepatotoxicity and reducing mortality. The timing of treatment initiation, within 8 to 24 hours after APAP overdose, is crucial for preventing or minimizing liver damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Zhenwei Yu, Yuhua Zhao, Jiayi Jin, Jianping Zhu, Lingyan Yu, Gang Han
Summary: This multicenter retrospective study evaluated the prevalence, clinical patterns, and risk factors for tigecycline-induced liver injury. The study found a high prevalence of tigecycline-induced liver injury, with the most common type being cholestatic and most cases having mild severity. Independent risk factors for tigecycline-induced liver injury included abnormal baseline alanine aminotransferase levels, intensive care unit admission, and treatment length.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Zhibo Gai, Sophia L. Samodelov, Irina Alecu, Thorsten Hornemann, Jane I. Grove, Guruprasad P. Aithal, Michele Visentin, Gerd A. Kullak-Ublick
Summary: Sphingolipid metabolism may be involved in the onset and progression of drug-induced liver injury (DILI), as evidenced by perturbations in plasma sphingolipid profiles in DILI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yong Zhang, Xueqian Chen, Qing Yuan, Yongning Bian, Mingrui Li, Yaling Wang, Xueyun Gao, Dongdong Su
Summary: Hepatotoxicity is a serious issue in clinical drugs, and liver injury caused by chronic administration or overdose has become a major biosafety concern. Currently used near-infrared fluorescent probes for liver injury detection face issues with poor liver targeting ability and low sensitivity. An enzyme-activated fluorogenic probe with strong in situ targeting ability is crucial for improving liver injury imaging.
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Immunology
Hao Wu, Chunqing Guo, Zheng Liu, Jinyang Cai, Chong Wang, Huanfa Yi, Arun Sanyal, Puneet Puri, Huiping Zhou, Xiang-Yang Wang
Summary: Drug-associated hepatotoxicity, particularly acetaminophen-induced liver injury (AILI), is a major cause of acute liver failure. This study reveals that serum levels of the pro-inflammatory cytokine interferon (IFN)- γ correlate with disease severity in patients with drug hepatotoxicity. The researchers found that hepatic neutrophils are the primary source of IFN- γ production in response to APAP-injured hepatocytes, and inhibition of IFN- γ effectively reduces hepatotoxicity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alexandre Nuzzo, Shireen Salem, Isabelle Malissin, Abdourahmane Diallo, Nicolas Deye, Antoine Goury, Herve Gourlain, Nicolas Peron, Eric Vicaut, Sebastian Voicu, Bruno Megarbane
Summary: This study aimed to assess the contribution of admission plasma procalcitonin concentration (PCT) in identifying acetaminophen-poisoned patients likely to develop liver injury. The results showed that PCT on admission was associated with liver injury in acetaminophen poisoning, and may be used as a predictive tool to improve clinical decision-making.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Sabine Weber, Alexander L. Gerbes
Summary: Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which poses a major challenge for diagnosis in clinical practice and pharmacovigilance. Efforts have been made to establish diagnostic testing methods and biomarkers for safe diagnosis and differentiation from other liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zhongyan Du, Zhimei Ma, Shanglei Lai, Qinchao Ding, Ziyi Hu, Wenwen Yang, Qianyu Qian, Linwensi Zhu, Xiaobing Dou, Songtao Li
Summary: This study aimed to evaluate the protective effects of Atractylenolide I (AO-I) against acetaminophen (APAP)-induced acute liver injury. The results showed that AO-I treatment significantly reversed APAP-induced liver injury, alleviated oxidative stress and inflammation, and inhibited the activation of TLR4/MAPKs/NF-kappa B pathways. AO-I is a potential therapeutic compound for APAP-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Xiaoyun Li, Jieting Tang, Yimin Mao
Summary: The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Antibiotics are the leading cause of DILI in Western countries, while traditional Chinese medicine is the primary cause in Eastern countries. The incidence of hepatotoxicity induced by herbal and dietary supplements is increasing globally. Although several risk factors for DILI have been described, there are no confirmed risk factors for all-cause DILI.
LIVER INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Yiwei Zhu, Lin Lei, Xinghui Wang, Linfang Chen, Wei Li, Jinxia Li, Chenchen Zhao, Xiliang Du, Yuxiang Song, Wenwen Gao, Guowen Liu, Xinwei Li
Summary: This study investigates the role of NEDD4-1 in the pathogenesis of acetaminophen-induced liver injury (AILI). The results demonstrate that NEDD4-1 acts as a suppressor of AILI by regulating the degradation of VDAC1.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji, Qiang You
Summary: The study demonstrated that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation. CD36 might serve as a new target to reduce acute liver injury.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yuguo Yi, Weigao Zhang, Liang Tao, Qianchao Shao, Qian Xu, Yuxin Chen, Haibing Zhang, Jianfa Zhang, Dan Weng
Summary: This study investigated the role of RIP1 kinase in APAP-induced acute liver injury through genetic or pharmacological inhibition, providing evidence that RIP1 kinase activity plays an important role in the pathogenesis of APAP-induced liver injury. The results demonstrated that RIP1 kinase inactivation significantly attenuated APAP-induced liver injury and mortality, and that Nec-1, a RIP1 kinase inhibitor formulated with PEG400, could efficiently alleviate hepatotoxicity induced by APAP.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xinghui Li, Jiaqi Ni, Li Chen
Summary: This review focuses on the diagnosis, screening, and management of Acetaminophen (APAP)-induced liver injury (AILI), which is a significant cause of drug-induced liver injury and acute liver failure. It summarizes recent research progress, highlights current issues, and provides recommendations for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Toxicology
Guillermo Quintas, Teresa Martinez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans, Jose Castell
Summary: DILI, an adverse toxic reaction associated with drug administration, is currently classified based on ALT and ALP values, but lacks accuracy. By integrating metabolomic information, a more accurate evaluation of DILI phenotypes can be achieved.
ARCHIVES OF TOXICOLOGY
(2021)