Mitochondrial targeting dendrimer allows efficient and safe gene delivery

Impact of siRNA Overhangs for Dendrimer-Mediated siRNA Delivery and Gene Silencing

(2013) Paola Posocco et al.   MOLECULAR PHARMACEUTICS

Polyplex-Induced Cytosolic Nuclease Activation Leads to Differential Transgene Expression

(2013) Rahul Rattan et al.   MOLECULAR PHARMACEUTICS

Mitochondrial Delivery of Doxorubicin by Triphenylphosphonium-Functionalized Hyperbranched Nanocarriers Results in Rapid and Severe Cytotoxicity

(2013) Theodossis A. Theodossiou et al.   PHARMACEUTICAL RESEARCH

Gene Therapy That Works

(2013) I. M. Verma   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria

(2012) Swati Biswas et al.   BIOMATERIALS

Arginine functionalized peptide dendrimers as potential gene delivery vehicles

(2012) Kui Luo et al.   BIOMATERIALS

Serum tolerance and endosomal escape capacity of histidine-modified pDNA-loaded complexes based on polyamidoamine dendrimer derivatives

(2012) Yuting Wen et al.   BIOMATERIALS

Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors

(2012) Yuebin Shan et al.   BIOMATERIALS

Theoretical and computational studies of dendrimers as delivery vectors

(2012) Wen-de Tian et al.   CHEMICAL SOCIETY REVIEWS

Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids

(2012) Eiji Yuba et al.   JOURNAL OF CONTROLLED RELEASE

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

(2012) Swati Biswas et al.   JOURNAL OF CONTROLLED RELEASE

Lipophilic and cationic triphenylphosphonium grafted linear polyethylenimine polymers for efficient gene delivery to mammalian cells

(2012) R. Bansal et al.   JOURNAL OF MATERIALS CHEMISTRY

Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA

(2012) Lina Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfide Cross-Linked Low Generation Dendrimers with High Gene Transfection Efficacy, Low Cytotoxicity, and Low Cost

(2012) Hongmei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyphosphonium Polymers for siRNA Delivery: An Efficient and Nontoxic Alternative to Polyammonium Carriers

(2012) Cátia Ornelas-Megiatto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potential Use of Lactosylated Dendrimer (G3)/α-Cyclodextrin Conjugates as Hepatocyte-Specific siRNA Carriers for the Treatment of Familial Amyloidotic Polyneuropathy

(2012) Yuya Hayashi et al.   MOLECULAR PHARMACEUTICS

Efficient in Vitro siRNA Delivery and Intramuscular Gene Silencing Using PEG-Modified PAMAM Dendrimers

(2012) Yin Tang et al.   MOLECULAR PHARMACEUTICS

Interview: An architectural journey: from trees, dendrons/dendrimers to nanomedicine

(2012) Donald A Tomalia   Nanomedicine

Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics

(2011) Jessica L. Cohen et al.   BIOCONJUGATE CHEMISTRY

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

(2011) Hibah Aldawsari et al.   BIOMATERIALS

Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma

(2011) Shixian Huang et al.   BIOMATERIALS

Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer

(2011) Xiaoxuan Liu et al.   MOLECULAR PHARMACEUTICS

Dendritic effects: dependency of dendritic nano-periodic property patterns on critical nanoscale design parameters (CNDPs)

(2011) Donald A. Tomalia   NEW JOURNAL OF CHEMISTRY

Acetal-Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non-Phagocytic Cells

(2010) Joel A. Cohen et al.   ADVANCED MATERIALS

Design, Synthesis, and Biological Evaluation of a Robust, Biodegradable Dendrimer

(2010) Derek G. van der Poll et al.   BIOCONJUGATE CHEMISTRY

Self-Assembled Terplexes for Targeted Gene Delivery with Improved Transfection

(2010) Qiao Zhang et al.   BIOCONJUGATE CHEMISTRY

Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration

(2010) Rongqin Huang et al.   BIOMATERIALS

Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer

(2010) Liang Han et al.   BIOMATERIALS

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

(2009) Weilun Ke et al.   BIOMATERIALS

PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells

(2009) Xiao-xuan Liu et al.   ChemMedChem

Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity

(2008) Hye Yeong Nam et al.   BIOMATERIALS

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo

(2008) Sarathi V. Boddapati et al.   NANO LETTERS