Pathogen-Induced Proapoptotic Phenotype and High CD95 (Fas) Expression Accompany a Suboptimal CD8+ T-Cell Response: Reversal by Adenoviral Vaccine

Infection with Trypanosoma cruzi Restricts the Repertoire of Parasite-Specific CD8+ T Cells Leading to Immunodominance

(2014) F. Tzelepis et al.   JOURNAL OF IMMUNOLOGY

A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-  in Macrophages and Fibroblasts

(2014) A.-D. C. Chessler et al.   JOURNAL OF IMMUNOLOGY

Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease

(2011) G.A. DosReis   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Pro- and anti-apoptotic CD95 signaling in T cells

(2011) Maren Paulsen et al.   Cell Communication and Signaling

Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi

(2011) Paula Ordonhez Rigato et al.   INFECTION AND IMMUNITY

Subdominant/Cryptic CD8 T Cell Epitopes Contribute to Resistance against Experimental Infection with a Human Protozoan Parasite

(2011) Mariana R. Dominguez et al.   PLoS One

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

(2011) N. L. Letvin et al.   Science Translational Medicine

Modulation of CD4+ T-cell activation by CD95 co-stimulation

(2010) M Paulsen et al.   CELL DEATH AND DIFFERENTIATION

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

(2010) Caroline Junqueira et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

(2010) Laurent Derré et al.   JOURNAL OF CLINICAL INVESTIGATION

Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8+ T Cells

(2010) D. Muraoka et al.   JOURNAL OF IMMUNOLOGY

CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are Not Required for Resistance

(2010) C. S. Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines against Angola Marburg Virus in Nonhuman Primates

(2010) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Chagas disease: changes in knowledge and management

(2010) François-Xavier Lescure et al.   LANCET INFECTIOUS DISEASES

Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species

(2010) Lisa E. Hensley et al.   PLoS Pathogens

Impaired Innate Immunity in Tlr4−/− Mice but Preserved CD8+ T Cell Responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-Deficient Mice

(2010) Ana-Carolina Oliveira et al.   PLoS Pathogens

Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon

(2009) S. Saint Fleur et al.   BLOOD

Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

(2009) B. Poonia et al.   BLOOD

CD8+ T cells in Trypanosoma cruzi infection

(2009) Angel M Padilla et al.   CURRENT OPINION IN IMMUNOLOGY

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

Perforin and Gamma Interferon Expression Are Required for CD4+ and CD8+ T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination

(2009) B. C. G. de Alencar et al.   INFECTION AND IMMUNITY

Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

(2009) A. Reyes-Sandoval et al.   INFECTION AND IMMUNITY

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

(2009) Gudrun Strauss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma cruzi Infection

(2009) A. M. Padilla et al.   JOURNAL OF IMMUNOLOGY

Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge

(2009) D. R. Casimiro et al.   JOURNAL OF VIROLOGY

The importance of apoptosis for immune regulation in Chagas disease

(2009) George A DosReis et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research

(2009) Julio Scharfstein et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true

(2009) Joseli Lannes-Vieira et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

New Insights on Adenovirus as Vaccine Vectors

(2009) Marcio O Lasaro et al.   MOLECULAR THERAPY

The role of parasite persistence in pathogenesis of Chagas heart disease

(2009) F. R. S. GUTIERREZ et al.   PARASITE IMMUNOLOGY

Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

(2009) Zhou Xing et al.   PLoS One

CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination

(2009) Tara Elvang et al.   PLoS One

Immunization of Mice with a Recombinant Adenovirus Vaccine Inhibits the Early Growth of Mycobacterium tuberculosis After Infection

(2009) Edward O. Ronan et al.   PLoS One

Role of the Fas/FasL pathway in HIV or SIV disease

(2009) Bhawna Poonia et al.   Retrovirology

Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection

(2009) Filipe A. Haolla et al.   VACCINE

Relationship between CD107a expression and cytotoxic activity

(2008) Esin Aktas et al.   CELLULAR IMMUNOLOGY

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

(2008) Kevin Bonney et al.   CURRENT MOLECULAR MEDICINE

Fas Bim Boom!

(2008) Douglas R. Green   IMMUNITY

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

(2008) Peter D. Hughes et al.   IMMUNITY

Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction

(2008) Ashley E. Weant et al.   IMMUNITY

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

(2008) Jinyan Liu et al.   NATURE

Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

(2008) György Fejer et al.   PLoS Pathogens