Article
Biochemistry & Molecular Biology
Jinxi Cheng, Xiaoyan Hou, Qiang Cui, Guanghui Shen, Shanshan Li, Qingying Luo, Man Zhou, Hong Chen, Zhiqing Zhang
Summary: This study successfully isolated and purified hydroxyl-alpha-sanshool, the main alkylamide produced by Z. armatum. The method used was simple, rapid, economical, and effective, providing a new approach for the separation of high-purity hydroxyl-alpha-sanshool.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.
Article
Agriculture, Multidisciplinary
Di Zhang, Xuhao Liu, Zhikun Yang, Jiyong Shi, Lei Zhao, Maurizio Battino, Jianbo Xiao, Xinyue Deng, Yanling Wu, Chengtao Wang, Bolin Shi, Xiaobo Zou
Summary: The study identified the key components in 26 varieties of Zanthoxylum pericarps responsible for inhibiting in vitro alpha-glucosidase. Using techniques like principal component analysis and ingredient recombination models, the researchers confirmed the antagonistic effect of phenols and hydroxy-alpha-sanshool in this inhibition process. Spectrophotometric assays, NMR, and MD were utilized to characterize the interactions among these components, shedding light on the structural mechanism behind their antagonistic behavior.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Zhaojun Chen, Lulin Tan, Feng Xin, Singab Abdel-nasser, Zunguo Lei, Liu Xiong
Summary: The study found that Sanshools, particularly hydroxy-gamma-sanshool (HRS) from Zanthoxylum bungeanum, have significant inhibitory effects on human colon adenocarcinoma cells. The Sanshools inhibited cell growth, induced cell cycle arrest at the G1 phase, and caused programmed cell death in a dose-dependent manner. The mechanisms involved up-regulation of P53 and Caspase 8 and down-regulation of Cyclin D1, CDK4, and PCNA. These findings suggest that Sanshools may have potential as a therapeutic agent for colorectal cancer.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Bin Xu, Wenjie He, Yang Yi, Hongxun Wang, Wei Xu, Danjun Guo
Summary: The mechanism of beta-sanshool in inhibiting the oxidation of myofibrillar protein in Zanthoxylum bungeanum Maxim was investigated. It was found that beta-sanshool can decrease the carbonyl content and increase the sulfhydryl content of the protein. The unfolding of protein structure and the increase in thermal denaturation temperature were observed with the addition of beta-sanshool, indicating its potential in enhancing protein stability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qing Zhang, Ruo-Lan Li, Ling-Yu Wang, Ting Zhang, Die Qian, Dan-Dan Tang, Cheng-Xun He, Chun-Jie Wu, Li Ai
Summary: The study evaluated the ameliorative effects of hydroxy-alpha-sanshool (HAS) on type 2 diabetes mellitus (T2DM). The results showed that HAS significantly reduced blood glucose levels, improved pathological changes in the liver and pancreas, and increased liver glycogen content. Furthermore, HAS promoted glucose uptake and glycogen synthesis by activating the PI3K/Akt/GSK-3β/GS signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Di Zhang, Xiaoxia Sun, Maurizio Battino, Xiaoou Wei, Jiyong Shi, Lei Zhao, Si Liu, Jianbo Xiao, Bolin Shi, Xiaobo Zou
Summary: This study compared the bioactive composition, organoleptic properties, and pharmacological activities of Sichuan pepper (pericarps and leaves) and chili pepper (fruits). It found that both peppers are rich in alkylamides, polyphenols, and odorants, but the structures of their bioactive ingredients are significantly different. Capsaicinoids are primarily identified in chili peppers while coumarins are specific to Sichuan pepper. The pungent sensations evoked by capsaicin and hydroxyl-alpha-sanshool are distinct due to their interactions with membrane ion channels. Additionally, extracts and compounds from both peppers show potential in alleviating various health conditions, but further clinical trials are needed to confirm their effects.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yujie Liu, Xianglong Meng, Lin Sun, Ke Pei, Lin Chen, Shuosheng Zhang, Meibian Hu
Summary: Hydroxy-alpha-sanshool (HAS) from Zanthoxylum bungeanum Maxim. has neuroprotective effects on AD mice by improving locomotion deficit, enhancing spatial learning and memory ability, alleviating morphological changes in the hippocampus, reducing oxidative stress, and inhibiting neuronal apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Christopher J. Miller, Yingyue Chang, Christina Wegeberg, Christine J. McKenzie, T. David Waite
Summary: This study demonstrates that the activation of [Fe-III(OH)(tpena)](+) by H2O2 proceeds by the formation of [Fe-III(OOH)(tpena)](+), which undergoes two major reactions to produce HO· and [Fe-IV(O)(tpena)](+). The production of HO· was quantified by a chemiluminescence method, showing that [Fe-IV(O)(tpena)](+) is produced in much larger yields than HO·. Additionally, the study indicates that a reactive high-valent iron-oxo species and HO· can be generated under mild, aqueous ambient conditions, which represents a significant contribution to biomimetic nonheme chemistry in water.
Article
Chemistry, Physical
Sajad Rasouli, Seyed Majid Hashemianzadeh
Summary: Understanding the thermal behavior and hybridization of cyclodextrin/adamantane inclusion complex is crucial for improving drug delivery systems. The research found that fi-cyclodextrin is the best host for capturing adamantane as the guest molecule. Increasing the solution temperature prevents the formation of the inclusion complex.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Stephane Caubergh, Nami Matsubara, Francoise Damay, Francois Fauth, Dmitry D. Khalyavin, Pascal Manuel, Abdelfattah Mahmoud, Dirk Poelman, Christine Martin, Benedicte Vertruyen
Summary: Different crystal phases of Fe2WO6 iron tungsten oxide were obtained through aqueous solution route, with solid solutions identified for Fe/W ratios not equal to 2. Crystallographic characterizations revealed features of ordered cationic distribution and reconstructive mechanism in the formation of different polymorphs.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Gastroenterology & Hepatology
Kotaro Maeda, Toshinobu Sasaki
Summary: The active ingredients of DKT, hydroxy-alpha-sanshool (HAS) and hydroxy-beta-sanshool (HBS), were found to enhance the contraction of the internal anal sphincter (IAS) in patients with constipation and fecal incontinence, but the mechanism is still unknown.
JOURNAL OF THE ANUS RECTUM AND COLON
(2023)
Article
Physics, Multidisciplinary
Hanan Alolaiyan, Halimah A. Alshehri, Muhammad Haris Mateen, Dragan Pamucar, Muhammad Gulzar
Summary: The study introduces the concept of complex fuzzy sets, including (alpha, beta)-complex fuzzy subgroups and (alpha, beta)-complex fuzzy normal subgroups, and proves some key properties.
Article
Neurosciences
Thomas W. Ward, Seth D. Springer, Mikki Schantell, Jason A. John, Lucy K. Horne, Anna T. Coutant, Hannah J. Okelberry, Madelyn P. Willett, Hallie J. Johnson, Abraham D. Killanin, Elizabeth Heinrichs-Graham, Tony W. Wilson
Summary: This study found that regular cannabis users show differences in motor control compared to nonusers, with stronger brain oscillations during the execution phase of the task. These findings suggest that users may employ compensatory processing in both primary motor and higher-order motor cortices to maintain task performance.
HUMAN BRAIN MAPPING
(2023)
Article
Chemistry, Applied
Yukun Zhao, Jingwen Xu, Hongbing Chen, Yi Xia, Lin Hu
Summary: A first iron-catalyzed oxophosphorylation reaction of styrene derivatives with dialkyl H-phosphonates under open air conditions is developed, leading to the formation of a range of previously underexplored α-substituted β-ketophosphonates. Additionally, a convenient one-pot procedure for the direct conversion of styrenes to α,β-unsaturated ketones is demonstrated, providing access to valuable products from simple starting materials.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
