Safety and immunogenicity of an investigational 4-componentStaphylococcus aureusvaccine with or without AS03Badjuvant: Results of a randomized phase I trial

Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphylococcus aureus Skin and Soft Tissue Infections

(2014) Christopher P. Mocca et al.   Clinical and Vaccine Immunology

Selection of an adjuvant for seasonal influenza vaccine in elderly people: modelling immunogenicity from a randomized trial

(2013) Hans C Rümke et al.   BMC INFECTIOUS DISEASES

Safety, Immunogenicity, and Antibody Persistence following an Investigational Streptococcus pneumoniae and Haemophilus influenzae Triple-Protein Vaccine in a Phase 1 Randomized Controlled Study in Healthy Adults

(2013) Johan Berglund et al.   Clinical and Vaccine Immunology

Immunogenicity Analysis of Staphylococcus aureus Clumping Factor A Genetic Variants

(2013) Rebecca A. Brady et al.   Clinical and Vaccine Immunology

A Serologic Correlate of Protective Immunity Against Community-Onset Staphylococcus aureus Infection

(2013) Stephanie A. Fritz et al.   CLINICAL INFECTIOUS DISEASES

Protein Antigens Increase the Protective Efficacy of a Capsule-Based Vaccine against Staphylococcus aureus in a Rat Model of Osteomyelitis

(2013) Santiago M. Lattar et al.   INFECTION AND IMMUNITY

Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery

(2013) Vance G. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Randomized, Controlled Dose-Finding Phase II Study of the M72/AS01 Candidate Tuberculosis Vaccine in Healthy PPD-Positive Adults

(2013) Jaime Montoya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Staphylococcus aureus Phenol-Soluble Modulin Peptides Modulate Dendritic Cell Functions and Increase In Vitro Priming of Regulatory T Cells

(2013) J. Schreiner et al.   JOURNAL OF IMMUNOLOGY

Safety and Immunogenicity of an AS01-adjuvanted Varicella-zoster Virus Subunit Candidate Vaccine Against Herpes Zoster in Adults >=50 Years of Age

(2013) R. Chlibek et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli

(2013) Michael Wacker et al.   JOURNAL OF INFECTIOUS DISEASES

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial

(2013) Janet E McElhaney et al.   LANCET INFECTIOUS DISEASES

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

(2013) Timothy J. Foster et al.   NATURE REVIEWS MICROBIOLOGY

Long-term persistence of humoral and cellular immune responses induced by an AS03A-adjuvanted H1N1 2009 influenza vaccine

(2013) Pierre Van Damme et al.   Human Vaccines & Immunotherapeutics

Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome

(2012) Yoshiyuki Minegishi et al.   Annals of the New York Academy of Sciences

A Recombinant Clumping Factor A-Containing Vaccine Induces Functional Antibodies to Staphylococcus aureus That Are Not Observed after Natural Exposure

(2012) Julio Hawkins et al.   Clinical and Vaccine Immunology

Meningococcal Quadrivalent (Serogroups A, C, W135 and Y) Tetanus Toxoid Conjugate Vaccine (Nimenrix™)

(2012) Jamie D. Croxtall et al.   DRUGS

Lower Antibody Levels to Staphylococcus aureus Exotoxins Are Associated With Sepsis in Hospitalized Adults With Invasive S. aureus Infections

(2012) R. P. Adhikari et al.   JOURNAL OF INFECTIOUS DISEASES

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Novel Structurally Designed Vaccine for S. aureus α-Hemolysin: Protection against Bacteremia and Pneumonia

(2012) Rajan P. Adhikari et al.   PLoS One

Development of a multicomponentStaphylococcus aureusvaccine designed to counter multiple bacterial virulence factors

(2012) Annaliesa S. Anderson et al.   Human Vaccines & Immunotherapeutics

Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials

(2012) Fabio Bagnoli et al.   Frontiers in Cellular and Infection Microbiology

Effect on Cellular and Humoral Immune Responses of the AS03 Adjuvant System in an A/H1N1/2009 Influenza Virus Vaccine Administered to Adults during Two Randomized Controlled Trials

(2011) François Roman et al.   Clinical and Vaccine Immunology

Progress Toward a Staphylococcus aureus Vaccine

(2011) R. S. Daum et al.   CLINICAL INFECTIOUS DISEASES

Recurrent infections and immune evasion strategies of Staphylococcus aureus

(2011) Hwan Keun Kim et al.   CURRENT OPINION IN MICROBIOLOGY

A new view on development of aStaphylococcus aureusvaccine

(2011) Brad Spellberg et al.   Human vaccines & immunotherapeutics

Human Monocytes Promote Th1 and Th17 Responses to Streptococcus pneumoniae

(2011) Marie Olliver et al.   INFECTION AND IMMUNITY

Staphylococcal Alpha-Toxin Is a Strong Inducer of Interleukin-17 in Humans

(2011) Margarete Niebuhr et al.   INFECTION AND IMMUNITY

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

(2011) L. R. Thurlow et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Comparative effects of carrier proteins on vaccine-induced immune response

(2011) Markus Knuf et al.   VACCINE

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

(2011) Sandra Morel et al.   VACCINE

Is there a future for a Staphylococcus aureus vaccine?

(2011) Richard A. Proctor   VACCINE

Evaluation of Clumping Factor A Binding Region A in a Subunit Vaccine against Staphylococcus aureus-Induced Mastitis in Mice

(2010) R. Gong et al.   Clinical and Vaccine Immunology

Role of Interleukin-17A in Cell-Mediated Protection against Staphylococcus aureus Infection in Mice Immunized with the Fibrinogen-Binding Domain of Clumping Factor A

(2010) K. Narita et al.   INFECTION AND IMMUNITY

H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

(2010) Philippe Moris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Safety and Cross‐Reactive Immunogenicity of Candidate AS03‐Adjuvanted Prepandemic H5N1 Influenza Vaccines: A Randomized Controlled Phase 1/2 Trial in Adults

(2010) Joanne M. Langley et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting of Alpha‐Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

(2010) Adam D. Kennedy et al.   JOURNAL OF INFECTIOUS DISEASES

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

10-valent pneumococcal nontypeableHaemophilus influenzaePD conjugate vaccine: Synflorix™

(2009) Roman Prymula et al.   Expert Review of Vaccines

Staphylococcal Vaccines and Immunotherapies

(2009) Adam C. Schaffer et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

(2009) Michael N. Hedrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome

(2009) Yoshiyuki Minegishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vaccination as infection control: A pilot study to determine the impact of Staphylococcus aureus vaccination on nasal carriage

(2009) C. Buddy Creech et al.   VACCINE

Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice

(2009) Lin Lin et al.   PLoS Pathogens

The expression of alpha-haemolysin is required forStaphylococcus aureusphagosomal escape after internalization in CFT-1 cells

(2008) Todd M. Jarry et al.   CELLULAR MICROBIOLOGY

Antibodies to Capsular Polysaccharide and Clumping Factor A Prevent Mastitis and the Emergence of Unencapsulated and Small-Colony Variants of Staphylococcus aureus in Mice

(2008) L. P. N. Tuchscherr et al.   INFECTION AND IMMUNITY

Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency

(2008) Y. Minegishi et al.   INTERNATIONAL IMMUNOLOGY

Vaccine protection againstStaphylococcus aureuspneumonia

(2008) Juliane Bubeck Wardenburg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Staphylococcus aureusClumping Factor A Binds to Complement Regulator Factor I and Increases Factor I Cleavage of C3b

(2008) Pamela S. Hair et al.   JOURNAL OF INFECTIOUS DISEASES

A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages

(2008) Malgorzata Kubica et al.   PLoS One

Broad Clade 2 Cross-Reactive Immunity Induced by an Adjuvanted Clade 1 rH5N1 Pandemic Influenza Vaccine

(2008) Isabel Leroux-Roels et al.   PLoS One

Fibrinogen Binding Sites P336 and Y338 of Clumping Factor A Are Crucial for Staphylococcus aureus Virulence

(2008) Elisabet Josefsson et al.   PLoS One

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

(2008) Pierre Vandepapelière et al.   VACCINE