Brain Alterations and Clinical Symptoms of Dementia in Diabetes: Aβ/Tau-Dependent and Independent Mechanisms

Can the Treatment of Vascular Risk Factors Slow Cognitive Decline in Alzheimer's Disease Patients?

(2018) Florence Richard et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural and Functional Brain Changes in Middle-Aged Type 2 Diabetic Patients: A Cross-Sectional Study

(2018) Natalia García-Casares et al.   JOURNAL OF ALZHEIMERS DISEASE

Risk of Incident Alzheimer's Disease in Diabetic Patients: A Systematic Review of Prospective Trials

(2017) Daniel Kopf et al.   JOURNAL OF ALZHEIMERS DISEASE

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases

(2014) Sophie M. Steculorum et al.   Alzheimers & Dementia

Microvascular network alterations in the retina of patients with Alzheimer's disease

(2014) Carol Yim-lui Cheung et al.   Alzheimers & Dementia

The Association of Duration of Type 2 Diabetes with Cognitive Performance is Modulated by Long-Term Glycemic Control

(2014) Rebecca K. West et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes

(2014) Serena Abbondante et al.   AMERICAN JOURNAL OF PATHOLOGY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease

(2014) Aisha Abeelen et al.   Current Alzheimer Research

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

(2014) I.R. Macdonald et al.   Current Alzheimer Research

Task-Induced Brain Activity Patterns in Type 2 Diabetes: A Potential Biomarker for Cognitive Decline

(2014) T. J. Marder et al.   DIABETES

Comment on Moore et al. Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin. Diabetes Care 2013;36:2981–2987

(2014) Mark O. Goodarzi   DIABETES CARE

Aberrant Brain Functional Connectivity Related to Insulin Resistance in Type 2 Diabetes: A Resting-State fMRI Study

(2014) Yu-Chen Chen et al.   DIABETES CARE

The ApoE4 genotype modifies the relationship of long-term glycemic control with cognitive functioning in elderly with type 2 diabetes

(2014) Ramit Ravona-Springer et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Differential subtypes of diabetic older adults diagnosed with Alzheimer's disease

(2014) Takashi Sakurai et al.   Geriatrics & Gerontology International

Spatial memory in sedentary and trained diabetic rats: Molecular mechanisms

(2014) João Carlos Diegues et al.   HIPPOCAMPUS

GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex

(2014) G. Molnar et al.   JOURNAL OF NEUROSCIENCE

Hyperlipidemic Diet Causes Loss of Olfactory Sensory Neurons, Reduces Olfactory Discrimination, and Disrupts Odor-Reversal Learning

(2014) N. Thiebaud et al.   JOURNAL OF NEUROSCIENCE

Diabetes and Elevated Hemoglobin A1c Levels Are Associated with Brain Hypometabolism but Not Amyloid Accumulation

(2014) R. O. Roberts et al.   JOURNAL OF NUCLEAR MEDICINE

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

(2014) Mari Takalo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cognitive decline and T2DM—a disconnect in the evidence?

(2014) Mark W. J. Strachan et al.   Nature Reviews Endocrinology

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions

(2014) R. Ossenkoppele et al.   NEUROLOGY

Association of type 2 diabetes with brain atrophy and cognitive impairment

(2014) R. O. Roberts et al.   NEUROLOGY

Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology

(2014) S. E. Monsell et al.   NEUROLOGY

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

A Pilot Study to Examine the Correlation between Cognition and Blood Biomarkers in a Singapore Chinese Male Cohort with Type 2 Diabetes Mellitus

(2014) Deborah Amanda Goh et al.   PLoS One

Insulin dysfunction and Tau pathology

(2014) Noura B. El Khoury et al.   Frontiers in Cellular Neuroscience

Hypoglycemia Is Independently Associated with Multidimensional Impairment in Elderly Diabetic Patients

(2014) A. Pilotto et al.   Biomed Research International

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

(2014) Dana M Niedowicz et al.   Acta Neuropathologica Communications

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

(2013) Janna H. Neltner et al.   BRAIN

Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles

(2013) C. H. Andrade-Moraes et al.   BRAIN

Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1

(2013) Agustin Cerani et al.   Cell Metabolism

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

(2013) Masaaki Hokama et al.   CEREBRAL CORTEX

Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

(2013) Y. Cui et al.   DIABETES

Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

(2013) W. S. Hoogenboom et al.   DIABETES

Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition

(2013) C. Moran et al.   DIABETES CARE

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Apathy correlates with prefrontal amyloid   deposition in Alzheimer's disease

(2013) T. Mori et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls

(2013) Josephine Barnes et al.   NEUROBIOLOGY OF AGING

Impaired glycemia increases disease progression in mild cognitive impairment

(2013) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Amyloid burden and neural function in people at risk for Alzheimer's Disease

(2013) Sterling C. Johnson et al.   NEUROBIOLOGY OF AGING

Higher glucose levels associated with lower memory and reduced hippocampal microstructure

(2013) L. Kerti et al.   NEUROLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors

(2013) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons

(2013) Ali Saleh et al.   Molecular Brain

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

Microvascular Dysfunction Is Associated With a Higher Incidence of Type 2 Diabetes Mellitus

(2012) Dennis M.J. Muris et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

(2012) Subir K. Roy Chowdhury et al.   NEUROBIOLOGY OF DISEASE

Sleep Disturbances in Alzheimer’s and Parkinson’s Diseases

(2012) Sarah M. Rothman et al.   NEUROMOLECULAR MEDICINE

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans

(2011) Peter Rasmussen et al.   FASEB JOURNAL

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy

(2011) Lenore J Launer et al.   LANCET NEUROLOGY

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

(2011) Shuko Takeda et al.   Molecular BioSystems

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats

(2011) A. Sherin et al.   NEUROSCIENCE

Spatial patterns of intrinsic brain activity in mild cognitive impairment and alzheimer's disease: A resting-state functional MRI study

(2010) Zhiqun Wang et al.   HUMAN BRAIN MAPPING

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

(2010) Dara L. Dickstein et al.   MOUNT SINAI JOURNAL OF MEDICINE

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Progression of brain atrophy and cognitive decline in diabetes mellitus: A 3-year follow-up

(2010) S. G. C. van Elderen et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Visuospatial Dysfunction May Be a Key in the Differentiation between Alzheimer’s Disease and Subcortical Cognitive Impairment in Moderate to Severe Stages

(2009) T. Fukui et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

(2009) J. L. Edwards et al.   DIABETOLOGIA

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus

(2009) Rachel A. Whitmer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Type 2 diabetes epidemic: a global education

(2009) The Lancet   LANCET

Alzheimer's disease: a global challenge for the 21st century

(2009) Jean François Dartigues   LANCET NEUROLOGY

Diabetes, microvascular pathology and Alzheimer disease

(2009) Raj N. Kalaria   Nature Reviews Neurology

Changing perspectives regarding late-life dementia

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Threats to the Mind: Aging, Amyloid, and Hypertension

(2008) C. Iadecola et al.   STROKE