Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies

Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

(2013) Dora Games et al.   AMERICAN JOURNAL OF PATHOLOGY

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

(2013) Silke Nuber et al.   BRAIN

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross-seeding effects of amyloid β-protein and α-synuclein

(2012) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

(2012) Filippo Caraci et al.   NEUROCHEMISTRY INTERNATIONAL

Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model

(2012) Ming-Hong Hsieh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Examining the mechanisms that link β-amyloid and α-synuclein pathologies

(2012) Samuel E Marsh et al.   Alzheimers Research & Therapy

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders

(2011) Richard M. Cleva et al.   MOLECULES

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

α-synuclein induced synapse damage is enhanced by amyloid-β1-42

(2010) Clive Bate et al.   Molecular Neurodegeneration

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease

(2010) Yolanda D. Black et al.   NEUROSCIENCE LETTERS

Alterations in mGluR5 Expression and Signaling in Lewy Body Disease and in Transgenic Models of Alpha-Synucleinopathy – Implications for Excitotoxicity

(2010) Diana L. Price et al.   PLoS One

Calcium dyshomeostasis and neurotoxicity of Alzheimer’s β-amyloid protein

(2009) Masahiro Kawahara et al.   Expert Review of Neurotherapeutics

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

(2009) João Daher et al.   Molecular Neurodegeneration

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

(2009) Cassia R. Overk et al.   NEUROBIOLOGY OF DISEASE

Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease

(2008) Pazit Bar-On et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

(2008) Igor F. Tsigelny et al.   PLoS One