Polyhydroxylated Metallofullerenols Stimulate IL-1β Secretion of Macrophage through TLRs/MyD88/NF-κB Pathway and NLRP3Inflammasome Activation

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine

(2013) Ligeng Xu et al.   ADVANCED MATERIALS

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

(2013) Paul M Peeters et al.   Particle and Fibre Toxicology

The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways

(2012) Hejiang Zhou et al.   BIOMATERIALS

Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

(2012) Eun-Jeong Yang et al.   BIOMATERIALS

Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives

(2012) Zhiyun Chen et al.   CURRENT DRUG METABOLISM

Krüppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages

(2012) Junwen Liu et al.   FEBS LETTERS

Particle-mediated delivery of cytokines for immunotherapy

(2012) David A Christian et al.   Immunotherapy

Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System

(2012) Ilse Van Brussel et al.   MEDIATORS OF INFLAMMATION

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

(2012) Jesus Segovia et al.   PLoS One

Enterohemorrhagic Escherichia coli Specific Enterohemolysin Induced IL-1β in Human Macrophages and EHEC-Induced IL-1β Required Activation of NLRP3 Inflammasome

(2012) Xiaoai Zhang et al.   PLoS One

Can immunotherapy be useful as a “functional cure” for infection with Human Immunodeficiency Virus-1?

(2012) Guido Vanham et al.   Retrovirology

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Applications of Functionalized Fullerenes in Tumor Theranostics

(2012) Zhiyun Chen et al.   Theranostics

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

(2011) Tomofumi Uto et al.   BIOMATERIALS

In Situ Synchrotron Radiation X-Ray Microspectroscopy of Polymer Microcontainers

(2011) Birgit Graf-Zeiler et al.   CHEMPHYSCHEM

The Immune Response to Tumors as a Tool toward Immunotherapy

(2011) F. Pandolfi et al.   Clinical & Developmental Immunology

In Vitroandin VivoAnticancer Activity of a Synthetic Glycolipid as Toll-like Receptor 4 (TLR4) Activator

(2011) Yong-Shiang Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells

(2011) Huan Meng et al.   Nanomedicine-Nanotechnology Biology and Medicine

Inflammasome activation and IL-1  target IL-1  for secretion as opposed to surface expression

(2011) A. Fettelschoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives

(2010) Huan Meng et al.   ACS Nano

[Gd@C82(OH)22]n Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses

(2010) De Yang et al.   ACS Nano

High Relaxivity Trimetallic Nitride (Gd3N) Metallofullerene MRI Contrast Agents with Optimized Functionality

(2010) Jianfei Zhang et al.   BIOCONJUGATE CHEMISTRY

Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model

(2010) Fang Jiao et al.   CARBON

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Photodynamic Antitumor Activity of Fullerene Modified with Poly(ethylene glycol) with Different Molecular Weights and Terminal Structures

(2010) Jian Liu et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Photodynamic therapy of fullerene modified with pullulan on hepatoma cells

(2010) Jian Liu et al.   JOURNAL OF DRUG TARGETING

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

(2010) Nicole B Bryan et al.   Journal of Inflammation-London

Modulation of Oxidative Stress by Functionalized Fullerene Materials in the Lung Tissues of Female C57/BL Mice with a Metastatic Lewis Lung Carcinoma

(2010) Fang Jiao et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

A recombinant lipoprotein containing an unsaturated fatty acid activates NF-κB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide

(2010) Chih-Hsiang Leng et al.   MOLECULAR IMMUNOLOGY

Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections

(2010) Zongshun Lu et al.   Nanomedicine

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Optical heating and rapid transformation of functionalized fullerenes

(2010) Vijay Krishna et al.   Nature Nanotechnology

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis

(2009) Fang Lao et al.   ACS Nano

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High1H Relaxivity

(2009) Chunying Shu et al.   BIOCONJUGATE CHEMISTRY

The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-α mediated cellular immunity

(2009) Ying Liu et al.   BIOMATERIALS

Immunostimulatory properties and enhanced TNF- α mediated cellular immunity for tumor therapy by C60(OH)20nanoparticles

(2009) Ying Liu et al.   NANOTECHNOLOGY

Fullerene derivatives protect endothelial cells against NO-induced damage

(2009) Fang Lao et al.   NANOTECHNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials

(2008) Jun-Jie Yin et al.   BIOMATERIALS

Is interleukin-1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?

(2008) Ron N. Apte et al.   IMMUNOLOGICAL REVIEWS

A Triacylated Lipoprotein from Mycoplasma genitalium Activates NF- B through Toll-Like Receptor 1 (TLR1) and TLR2

(2008) T. Shimizu et al.   INFECTION AND IMMUNITY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE