Article
Optics
Yu Zhao, Xixi Cui, Zhiwei Ge, Qingtian Meng, Changzhe Zhang
Summary: This theoretical study investigates the optical properties of a set of fluorescent cytosine analogues as indicators to analyze structural changes during the formation of a four-stranded intercalated motif (i-motif). The modified cytosine analogues exhibit red-shifted absorption and bright fluorescence emission, making them potential candidates for detecting i-motif structure. The study also reveals fluorescence quenching induced by proton transfer depending on base pairing, serving as an efficient optical probe during the i-motif formation process.
JOURNAL OF LUMINESCENCE
(2021)
Article
Biochemical Research Methods
Bin Wang, Eric Chatterton
Summary: This study investigates the feasibility of using capillary electrophoresis as an alternative method for i-motif related research, with results showing that capillary electrophoresis can identify and differentiate different states of DNA and RNA i-motifs through changes in peak shape and migration time.
Article
Biochemistry & Molecular Biology
Kelly L. Irving, Jessica J. King, Zoe A. E. Waller, Cameron W. Evans, Nicole M. Smith
Summary: DNA is capable of forming alternative secondary structures, including the i-motif, which was previously believed to be unstable in cellular environments. Recent studies have shown the existence of i-motifs in the human genome and their role in gene regulation. This review discusses the effects of epigenetic modifications on i-motif structure, factors influencing i-motif formation in cells, and highlights the recent progress in targeting i-motifs for biotechnology and therapeutic purposes.
Article
Chemistry, Multidisciplinary
Angelos Mourkas, Angeliki Zarlaha, Nikolaos Kourkoumelis, Ioannis Panagiotopoulos
Summary: The impact of magnetic fields on the spatial arrangement of superparamagnetic nanospheres is explored, introducing long range magnetic dipolar interactions. Different assembly characteristics are observed with different methods and field directions. Perfect hexagonal arrays, directional patterns, and 3D-accumulation are obtained under specific conditions.
Article
Chemistry, Multidisciplinary
Arppitha Baby Sainaba, Mangili Venkateswarulu, Pallab Bhandari, Jack K. Clegg, Partha Sarathi Mukherjee
Summary: Aesthetically captivating structures can be formed by tuning the length or flexibility of various components through coordination-driven self-assembly. This research showcases the ability to design and fabricate novel, topologically distinctive molecular structures by a straightforward and efficient approach.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Bingrui Liu, Yuyan Li, Yuan Yuan, Bosen Zheng, Chang Liu, Lijuan Zhou, Jianming Zhang
Summary: Phosphoric acid is used as a favorable alternative to strong acids in the production of cellulose nanospheres (CNS). In this study, CNS was synthesized from natural cotton pulp using phosphoric acid hydrolysis, achieving a reduced production time of 4 hours compared to the reported 12-hour hydrolysis. The size of the CNS was further controlled by changing the hydrolysis time, and the thermal stability of the CNS generated from phosphoric acid hydrolysis was significantly greater compared to sulphuric acid hydrolysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Alejandra de la Hoz, Alba Navarro, Anna Avino, Ramon Eritja, Raimundo Gargallo
Summary: The study investigated the interaction of different DNA sequences with silver ions (Ag(i)) and the impact of experimental variables on the fluorescence properties of DNA-stabilized AgNCs. The results highlighted the significant role of the secondary structure of DNA probes in affecting the fluorescence properties, offering insights for the development of miRNA detection methods.
Article
Engineering, Environmental
Haihui Wang, Yifan Jiang, Yichang Liu, Xiaohui Zhu, Yongfei Liu, Minle Chen, Tao Zeng, Zhaowei Chen, Jinyu Li, Chunhua Lu, Huanghao Yang
Summary: This study proposes a straightforward approach for preparing multifunctional DNA-based nanospheres through the direct self-assembly of 2'-fluoro-substituted single-stranded DNA (2'F-DNA) with various small molecules. Molecular dynamics simulation reveals that 2'F substitution in DNA can cause repulsion of adjacent PO(4)(3-) groups, leading to local stretching of the DNA structure. Additionally, the 2'F substituent induces the regular polarization of H2O nearby F to form a hydration layer, which disrupts inherent interactions among bases. This approach allows for the construction of engineering hybrid nanospheres using DNA and other small molecules, holding great potential for further biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Kangkang Zhi, Huilan Yang, Zhongguo Shan, Kerang Huang, Min Zhang, Xiaodong Xia
Summary: Debranching and subsequent hydroxypropylation were used to prepare a series of dual-modified starches (HPDS) which were successfully employed to encapsulate curcumin, enhancing its bioavailability, solubility, and stability. The HPDS nanospheres exhibited good safety and sustained release properties, with the encapsulated curcumin showing improved anti-inflammatory activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biophysics
Hui Liu, Yunshan Zhang, Zhoumin Zhang, Zhiwei Deng, Jiaqi Bu, Tianhao Li, Jing Nie, Xiangxiang Qin, Yanjing Yang, Shian Zhong
Summary: Controllable size and self-degradability of DNA nanospheres were achieved by hybridization of i-motif and linker strands. The size of DNA nanospheres was regulated by the linker sequence, and their self-degradation ability was pH-responsive due to the i-motif strand. The introduction of ZY11 aptamer allowed for targeting of SMMC-7721 cancer cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Dan Su, Lei Lv, Yi Yang, Huan-Li Zhou, Sami Iqbal, Tong Zhang
Summary: Nanomaterials and nanostructures offer new opportunities for high-performance optical and optoelectronic devices, with a proposed self-assembly strategy demonstrating controllable density and layering for 3D substrates. The close-packed SiO2 monolayer showed a maximum relative efficiency enhancement of 9.35%, attributed to a concentration effect and anti-reflection of incident light induced by nanospheres. This versatile strategy provides a cost-effective approach for engineering nanomaterials at 3D interfaces.
Article
Chemistry, Inorganic & Nuclear
Mamina Bhol, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: A family of neutral, heteroleptic, dinuclear pentagonal toroid-shaped metallomacrocycles were synthesized using a one-pot solvothermal self-assembly approach. The cyclic inner cavities of the metallomacrocycles can accommodate guest molecules and exhibit host-guest recognition properties.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qirui Liu, Yinlong Tan, Renyan Zhang, Yan Kang, Ganying Zeng, Xiaoming Zhao, Tian Jiang
Summary: The study introduces a facile and universal method for conformal self-assembly of nanospheres on various substrates, which has promising applications in fields like optics and sensors.
Article
Chemistry, Multidisciplinary
Liao-Yuan Yao, Lin Qin, Ziyong Chen, Jonathan Lam, Vivian Wing-Wah Yam
Summary: This study explores the importance and mechanism of chiral self-assembly and self-sorting in gold cluster systems. By introducing ligands with different chirality, unique chiral gold clusters with specific shapes were successfully synthesized. Both homochiral and heterochiral self-sorting processes were observed, as well as the transfer of chirality from ligands to gold clusters, resulting in changes in symmetry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Multidisciplinary
Haibo Long, Liangke Hu, Feiwen Yang, Qilong Cai, Zhong Zhong, Shuting Zhang, Litao Guan, Dingshu Xiao, Wenxu Zheng, Wuyi Zhou, Yen Wei, Ko Frank, Xianming Dong
Summary: Lignin nanospheres with low cost, high specific surface and good dispersibility were successfully prepared and used as fillers to reinforce polylactic acid (PLA). The addition of EALNSs significantly improved the mechanical properties of the composites.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
J. Feng, K. Liu, M. Graf, M. Lihter, R. D. Bulushev, D. Dumcenco, D. T. L. Alexander, D. Krasnozhon, T. Vuletic, A. Kis, A. Radenovic
Article
Nanoscience & Nanotechnology
Gennady Eidelshtein, Alexander Kotlyar, Mohtadin Hashemi, Leonid Gurevich
Article
Nanoscience & Nanotechnology
Jiandong Feng, Ke Liu, Roman D. Bulushev, Sergey Khlybov, Dumitru Dumcenco, Andras Kis, Aleksandra Radenovic
NATURE NANOTECHNOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Gennady Eidelshtein, Natalie Fardian-Melamed, Vitaly Gutkin, Dmitry Basmanov, Dmitry Klinov, Dvir Rotem, Yael Levi-Kalisman, Danny Porath, Alexander Kotlyar
ADVANCED MATERIALS
(2016)
Article
Multidisciplinary Sciences
Jiandong Feng, Michael Graf, Ke Liu, Dmitry Ovchinnikov, Dumitru Dumcenco, Mohammad Heiranian, Vishal Nandigana, Narayana R. Aluru, Andras Kis, Aleksandra Radenovic
Article
Chemistry, Physical
Jiandong Feng, Ke Liu, Michael Graf, Dumitru Dumcenco, Andras Kis, Massimiliano Di Ventra, Aleksandra Radenovic
Article
Chemistry, Multidisciplinary
Gennady Eidelshtein, Moran Fattal, Gavriel Avishai, Benjamin Kempinski, Clelia Giannini, Alexander Kotlyar
Article
Chemistry, Multidisciplinary
Huanyao Cun, Adrian Hemmi, Elisa Miniussi, Carlo Bernard, Benjamin Probst, Ke Liu, Duncan T. L. Alexander, Armin Kleibert, Gerson Mette, Michael Weinl, Matthias Schreck, Jurg Osterwalder, Aleksandra Radenovic, Thomas Greber
Review
Genetics & Heredity
Gabor Zsurka, Viktoriya Peeva, Alexander Kotlyar, Wolfram S. Kunz
Article
Multidisciplinary Sciences
Ke Liu, Chao Pan, Alexandre Kuhn, Adrian Pascal Nievergelt, Georg E. Fantner, Olgica Milenkovic, Aleksandra Radenovic
NATURE COMMUNICATIONS
(2019)
Article
Biochemical Research Methods
Liat Katrivas, Benjamin Kempinski, Kfir Kuchuk, Uri Sivan, Alexander Kotlyar
BIOCONJUGATE CHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
Galina Proshkina, Sergey Deyev, Anastasiya Ryabova, Francesco Tayanti, Maria Cristina Menziani, Roy Cohen, Liat Katrivas, Alexander Kotlyar
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Oncology
Galina Proshkina, Elena Shramova, Anastasiya Ryabova, Liat Katrivas, Clelia Giannini, Daniele Malpicci, Yael Levi-Kalisman, Sergey Deyev, Alexander Kotlyar
Summary: This study demonstrates a methodology to enhance the solubility of peptide nucleic acid (PNA) and delivers it specifically to cancer cells using designed ankyrin repeat protein (DARPin)-functionalized small multilamellar vesicles (SMVs). The positively charged PNA molecules bind electrostatically to the negatively charged phospholipid membranes, encapsulating the PNA in the vesicles. The DARPin-functionalized SMVs can enter HER2-overexpressing cells and cause cell death by interfering with normal cell functioning.
Article
Biochemical Research Methods
Sergey Deyev, Galina Proshkina, Anastasiya Ryabova, Francesco Tavanti, Maria Cristina Menziani, Gennady Eidelshtein, Gavriel Avishai, Alexander Kotlyar
BIOCONJUGATE CHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Yaron Dekel, Yossy Machluf, Tal Gefen, Gennady Eidelshtein, Alexander Kotlyar, Yaron Bram, Ehud Shahar, Farah Reslane, Elina Aizenshtein, Jacob Pitcovski
