Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease

(2018) Gonzalo S. Nido et al.   NEUROBIOLOGY OF AGING

Origins of mtDNA mutations in ageing

(2017) Karolina Szczepanowska et al.   Essays in Biochemistry

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

(2017) Sian Genoud et al.   Metallomics

Selective mitochondrial DNA degradation following double-strand breaks

(2017) Amandine Moretton et al.   PLoS One

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy

(2016) Elisa Volmering et al.   ACTA NEUROPATHOLOGICA

Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage

(2016) Jake G. Hoekstra et al.   ANNALS OF NEUROLOGY

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences

(2015) Conceição A. S. A. Minetti et al.   BIOPOLYMERS

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

(2015) Olivier R. Baris et al.   Cell Metabolism

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

The Parkinson Disease Mitochondrial Hypothesis

(2015) Sandra Franco-Iborra et al.   NEUROSCIENTIST

In vivolevels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice

(2014) Angela Logan et al.   AGING CELL

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

(2014) Thomas J. Nicholls et al.   HUMAN MOLECULAR GENETICS

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Maternally transmitted mitochondrial DNA mutations can reduce lifespan

(2014) Jaime M. Ross et al.   Scientific Reports

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases

(2014) Guofen Gao et al.   Frontiers in Pharmacology

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis

(2012) Graham R. Campbell et al.   ACTA NEUROPATHOLOGICA

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Running on empty: Does mitochondrial DNA mutation limit replicative lifespan in yeast?

(2011) Cory D. Dunn   BIOESSAYS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial changes associated with demyelination: Consequences for axonal integrity

(2011) Graham R. Campbell et al.   MITOCHONDRION

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

(2011) Brendan A I Payne et al.   NATURE GENETICS

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Complex III-dependent superoxide production of brain mitochondria contributes to seizure-related ROS formation

(2010) Dominika Malinska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeats, longevity and the sources of mtDNA deletions: evidence from ‘deletional spectra’

(2010) Xinhong Guo et al.   TRENDS IN GENETICS

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

(2009) Laura J. Bailey et al.   NUCLEIC ACIDS RESEARCH

Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects

(2008) Keir J. Menzies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment

(2008) Werner J.H. Koopman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of iron in mitochondrial function

(2008) Sonia Levi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Locating the stem cell niche and tracing hepatocyte lineages in human liver

(2008) Tariq G. Fellous et al.   HEPATOLOGY

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

(2008) Hirokazu Fukui et al.   HUMAN MOLECULAR GENETICS

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS