A microvalve for lab-on-a-chip applications based on electrochemically actuated SU8 cantilevers

Increasing the complexity and functionality of Lab-on-a-Chip devices requires integrated valves for internal flow regulation. The device introduced in this work is an electrochemical SU8 microvalve, featuring a cantilevered structure that seals an adjacent channel under the action of a growing electrolysis bubble. The valve is based on previously reported movable microcantilevers embedded in microchannels. As opposed to membrane valves moving perpendicular to the substrate, the cantilever valve is patterned next to the channel and closes it by moving horizontally, dramatically reducing footprint. Its compact, monolithic and 2D construction reduces assembly problems and results in negligible increase in dead volume (14.5 nl). Besides, its location in the way of the channels avoids the need for auxiliary filling ports or separate working media for actuation. Effective sealing with negligible leakage at 20 kPa has been achieved. The valve also displays passive flow regulation induced by the pressure differential generated across the valve chamber under flow conditions (42-72% flow decrease). (C) 2010 Elsevier B.V. All rights reserved.