High-Throughput Methods for Combinatorial Drug Discovery

Systematic identification of proteins that elicit drug side effects

(2013) M. Kuhn et al.   Molecular Systems Biology

Predicting and characterizing selective multiple drug treatments for metabolic diseases and cancer

(2012) Giuseppe Facchetti et al.   BMC Systems Biology

Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model

(2012) N. Floc'h et al.   CANCER RESEARCH

A Whole-Cell Computational Model Predicts Phenotype from Genotype

(2012) Jonathan R. Karr et al.   CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Synthetic lethality for linking the mycophenolate mofetil mode of action with molecular disease and drug profiles

(2012) Johannes Söllner et al.   Molecular BioSystems

Neighbor communities in drug combination networks characterize synergistic effect

(2012) Jun Zou et al.   Molecular BioSystems

Systematic identification of synergistic drug pairs targeting HIV

(2012) Xu Tan et al.   NATURE BIOTECHNOLOGY

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

(2012) Lawrence N Kwong et al.   NATURE MEDICINE

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

(2012) Sarah R Gilman et al.   NATURE NEUROSCIENCE

ExPASy: SIB bioinformatics resource portal

(2012) P. Artimo et al.   NUCLEIC ACIDS RESEARCH

Data-Driven Prediction of Drug Effects and Interactions

(2012) N. P. Tatonetti et al.   Science Translational Medicine

An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data

(2011) G. Jin et al.   BIOINFORMATICS

Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels

(2011) N P Tatonetti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Predicting Adverse Drug Events Using Pharmacological Network Models

(2011) A. Cami et al.   Science Translational Medicine

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition

(2011) Neda Bagheri et al.   PLoS Computational Biology

Gene prioritization in Type 2 Diabetes using domain interactions and network analysis

(2010) Amitabh Sharma et al.   BMC GENOMICS

Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff

(2010) Munir Pirmohamed   WIENER KLINISCHE WOCHENSCHRIFT

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

The use of network analyses for elucidating mechanisms in cardiovascular disease

(2009) Diego Diez et al.   Molecular BioSystems

Chemogenomic profiling predicts antifungal synergies

(2009) Gregor Jansen et al.   Molecular Systems Biology

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

High-order combination effects and biological robustness

(2008) Joseph Lehár et al.   Molecular Systems Biology

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Search Algorithms as a Framework for the Optimization of Drug Combinations

(2008) Diego Calzolari et al.   PLoS Computational Biology