Oxadiazoles as Privileged Motifs for Promising Anticancer Leads: Recent Advances and Future Prospects

Zibotentan

(2015) N.D. James et al.   DRUGS OF THE FUTURE

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

(2013) Aliya Ibrar et al.   ARCHIV DER PHARMAZIE

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

(2013) Qian-Ru Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: The special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole

(2013) Andrei A. Gakh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Quantitative Structure^|^#8211;Activity Relationship and Biological Evaluation of 1,3,4-Oxadiazole Derivatives Possessing Diphenylamine Moiety as Potential Anticancer Agents

(2013) Doaa Ezzat Abdel Rahman   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and evaluation of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles as anti-cancer agents

(2013) H.D. Gurupadaswamy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triazolothiadiazoles and triazolothiadiazines – Biologically attractive scaffolds

(2013) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular docking study, and anticancer activity of triaryl-1,2,4-oxadiazole

(2013) Parisa Miralinaghi et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, Acetylcholinesterase and Alkaline Phosphatase Inhibition of Some New 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives

(2012) Imtiaz Khan et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

(2012) Li-Rong Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives

(2012) Jie Ren et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,4-Oxadiazoles: A new class of anti-prostate cancer agents

(2012) Gopal L. Khatik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents

(2012) Asif Husain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer polysaccharides from natural resources: A review of recent research

(2012) Aizhen Zong et al.   CARBOHYDRATE POLYMERS

Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents

(2012) Mohd Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent

(2012) Juan Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Platinum(II) Complexes Containing Platinum-Based Moieties of Present Platinum Drugs and Furoxan Groups as Nitric Oxide Donors: Synthesis, DNA Interaction, and Cytotoxicity

(2012) Jian Zhao et al.   INORGANIC CHEMISTRY

Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents

(2012) Isaac T. Schiefer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives

(2012) Kamil Brożewicz et al.   MONATSHEFTE FUR CHEMIE

Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors

(2012) Daniela Masciocchi et al.   MedChemComm

Synthesis and Cytotoxicity of Bis-1,3,4-oxadiazoles and Bis-pyrazoles Derived from 1,4-Bis[5-thio-4-substituted-1,2,4-triazol-3-Yl]-butane and Their DNA Binding Studies

(2011) Madhusudan Purohit et al.   ARCHIV DER PHARMAZIE

Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents

(2011) Xiao-Min Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents

(2011) Yang Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel 1,3,4-oxadiazole derivatives and their nucleoside analogs with antioxidant and antitumor activities

(2011) A. A. Fadda et al.   Chemistry of Heterocyclic Compounds

Synthesis of novel 1,2,4-oxadiazoles and analogues as potential anticancer agents

(2011) Dalip Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles

(2011) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents

(2011) Kai Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structure and β-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives

(2011) Muhammad Hanif et al.   MEDICINAL CHEMISTRY RESEARCH

Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

(2011) Marianna Carbone et al.   ORGANIC LETTERS

2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization

(2011) Ahmed Kamal et al.   MedChemComm

Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino}indolin-2-one derivatives

(2011) Rajyalakshmi Gudipati et al.   SAUDI PHARMACEUTICAL JOURNAL

Stereoselective Synthesis and Antiviral Activity of (1E,2Z,3E)-1-(Piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol- 2-oyl)hydrazono]-4-(aryl1)but-3-enes

(2010) Hatem A. Abdel-Aziza et al.   ARCHIV DER PHARMAZIE

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

(2010) Yong Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents

(2010) Yong Ling et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytotoxicity and Utility of 1-Indanone in the Synthesis of Some New Heterocycles

(2010) Bahira Hegazi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays

(2010) Alex S. Kiselyov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives

(2010) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro anti-tumor activity of new oxadiazole thioglycosides

(2010) M.A. Abu-Zaied et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Oxadiazole Analogues Derived from Ethacrynic Acid: Design, Synthesis, and Structure−Activity Relationships in Inhibiting the Activity of GlutathioneS-Transferase P1-1 and Cancer Cell Proliferation

(2010) Xinmei Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of some novel 3,5-disubstituted 1,3,4-oxadiazole derivatives and anticancer activity on EAC animal model

(2010) Sasmita Dash et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antitumor evaluation of some 1,3,4-oxadiazole-2(3H)-thione and 1,2,4-triazole-5(1H)-thione derivatives

(2010) ChengTao Feng et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, modeling, and crystallographic study of 3,4-disubstituted-1,2,5-oxadiazoles and evaluation of their ability to decrease STAT3 activity

(2010) Dae-Seop Shin et al.   MedChemComm

Molecular interactions in cancer cell metastasis

(2009) Susan A. Brooks et al.   ACTA HISTOCHEMICA

Synthesis and Biological Evaluation of Some Novel Polysubstituted Pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents

(2009) Sherif A. F. Rostom et al.   ARCHIV DER PHARMAZIE

Tumor heterogeneity: Causes and consequences

(2009) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4-oxadiazoles

(2009) Dalip Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

(2009) Wen-Shan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiangiogenic and antiproliferative effects of substituted-1,3,4-oxadiazole derivatives is mediated by down regulation of VEGF and inhibition of translocation of HIF-1α in Ehrlich ascites tumor cells

(2009) Akhilesh Kumar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cancer systems biology: a network modeling perspective

(2009) P. K. Kreeger et al.   CARCINOGENESIS

The global burden of cancer: priorities for prevention

(2009) M. J. Thun et al.   CARCINOGENESIS

Synthesis, Modelling, and Antimitotic Properties of Tricyclic Systems Characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole Moiety

(2009) Gérard A. Pinna et al.   ChemMedChem

Emerging Treatments in Cystic Fibrosis

(2009) Andrew M. Jones et al.   DRUGS

First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin

(2009) Zhi-Wei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GPR119 agonists for the treatment of type 2 diabetes

(2009) Robert M Jones et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

(2009) Yunsong Tong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

(2009) Hongqin Zhuang et al.   LUNG CANCER

The new era of 1,2,4-oxadiazoles

(2009) Andrea Pace et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of novel β-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole

(2008) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives

(2008) Anelise S. Nazari Formagio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives

(2008) Akhilesh Kumar et al.   INVESTIGATIONAL NEW DRUGS

Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents

(2008) Vivek Kumar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Biarylpyrazolyl Oxadiazole as Potent, Selective, Orally Bioavailable Cannabinoid-1 Receptor Antagonists for the Treatment of Obesity

(2008) Suk Ho Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship

(2008) Ahcène Boumendjel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY