Journal
CANCER LETTERS
Volume 267, Issue 2, Pages 189-196Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.03.013
Keywords
nuclear receptor; inflammation; cancer
Categories
Funding
- Ministry of Health AMP
- Welfare and the Molecular and Cellular BioDiscovery Research Program
- MOST/KOSEF
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Functional role of nuclear receptors and numerous coregulators have been Studied in terms Of regulating transcriptional control of genes that play critical roles in various pathways. There is growing evidence that nuclear receptors and their coregulators control inflammatory programs of gene expression and progression of hormone-dependent cancer. This review provides a general overview of the interrelationship between nuclear receptor signalling, inflammation and cancer. These insights provide inflammatory genes as attractive targets for the development of cancer therapeutics. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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