Article
Immunology
Tao Lin, Ling Ding, Yicheng Lin, Chunbo Liu, Changzhen Wang, Dahao Wu, Zhe Li, Meng Li, Jinlong Sun
Summary: This study found that the use of TLR4 inhibitor TAK-242 can effectively prevent the occurrence of posthemorrhagic hydrocephalus and improve the prognosis. Its mechanism of action involves the regulation of the TLR4-NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Justine Chivot, Nathalie Ferrand, Aude Fert, Patrick Van Dreden, Romain Morichon, Michele Sabbah
Summary: PARPi, as potent inhibitors, can inhibit the formation of vasculogenic mimicry in triple negative breast cancer cells independently of BRCA status. Mechanistically, PARPi trigger and inhibit the NF-kappa B signaling and downregulate the expression of angiogenic factor PTX3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Gehad Subaiea, Ahmed Alafnan, Abdulwahab Alamri, Talib Hussain, Shimaa Mahmoud Hassoun, Amr Selim Abu Lila, El-Sayed Khafagy, Ahmed A. A. Katamesh
Summary: "Umo Ishi" is a novel written by Kenzaburo Oe, in which the author reflects on and pursues peace and justice through a review of history and reality. Set against the backdrop of the Chinese resistance during World War II, the novel portrays the devastation of war on ordinary people and the distortion of human nature through the lives and inner monologues of different characters. By depicting the brutality of war and the complexity of human nature, the novel explores the meaning and impact of war on humanity, and calls for the pursuit of peace.
Article
Fisheries
Zhangping Wang, Xiaoyue Sun, Wenbo Wang, Mingjuan Zheng, Daochuan Zhang, Hong Yin
Summary: Nuclear factor-kappa B (NF-kappa B) plays a crucial role in regulating intestinal inflammation and maintaining gut epithelial integrity. Its activation controls the expression of various factors and helps to reduce intestinal damage. IL17, on the other hand, enhances NF-kappa B activation and contributes to intestinal inflammation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Rajakrishnan Veluthakal, Eunjin Oh, Miwon Ahn, Diti Chatterjee Bhowmick, Debbie C. Thurmond
Summary: Enrichment of human islets with syntaxin 4 improves beta-cell mass through NF-kappa B-dependent mechanism. STX4 suppresses cytokine-induced degradation of I kappa B beta, protecting islet beta-cells from cytokine-mediated dysfunction. This study proposes a novel pathway where STX4 regulates NF-kappa B signaling in beta-cells, preventing I kappa B beta degradation and suppressing chemokine expression.
Article
Cell Biology
Qing-Quan Liu, Yu-Wen Liu, Yuan-Kang Xie, Jian-Hong Zhang, Cai-Xin Song, Jian-Zhong Wang, Bin-Hui Xie
Summary: The study found that DDR2 expression was significantly upregulated in sorafenib-resistant HCC tissues, and downregulation of DDR2 sensitized HCC cell lines to sorafenib cytotoxicity. Further analysis showed that DDR2 could increase the nuclear location of REL proto-oncogene, a NF-kappa B subunit, to mediate NF-kappa B signaling. Blocking NF-kappa B signaling using the NF-kappa B signaling inhibitor, bardoxolone methyl, increased the response of HCC cells to sorafenib.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Kamila Kitowska, Monika Gorska-Arcisz, Dima Antoun, Izabela Zarczynska, Dominika Czaplinska, Adrian Szczepaniak, Andrzej C. Skladanowski, Maciej Wieczorek, Aleksandra Stanczak, Monika Skupinska, Rafal Sadej
Summary: Bidirectional regulation of fibroblast growth factor receptor (FGFR) signaling due to FGFR amplification, chromosomal translocation, or mutations is linked to initiation and progression of various human cancers. Clinical data highlight FGFRs as potential targets for anti-cancer therapies, with acquired resistance to tyrosine kinase inhibitors posing a significant challenge. Evaluation of a novel pan-FGFR inhibitor, CPL304110, in cancer cell lines with aberrant FGFR signaling revealed a potential resistance mechanism involving increased MET expression. Targeting the MET/Pyk2 signaling axis could potentially overcome resistance in lung, gastric, and bladder cancer cells, providing a new avenue for FGFR inhibition therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Immunology
Lingqi Kong, Wenyu Li, E. Chang, Wuxuan Wang, Nan Shen, Xiang Xu, Xinyue Wang, Yan Zhang, Wen Sun, Wei Hu, Pengfei Xu, Xinfeng Liu
Summary: This study demonstrates that STING, activated by mtDNA, promotes microglial polarization towards the M1 phenotype following ischemic stroke. Inhibition of STING may serve as a potential therapeutic strategy to mitigate neuroinflammation and improve stroke outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michela Palleschi, Gianluca Tedaldi, Marianna Sirico, Alessandra Virga, Paola Ulivi, Ugo De Giorgi
Summary: PARP inhibitors are effective drugs for treating tumors with BRCA1/2 mutations, with potential applications in both monotherapy and combination therapy for breast cancer, showing essential clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Bo He, Chao Wu, Weichao Sun, Yang Qiu, Jingyao Li, Zhihui Liu, Tao Jing, Haidong Wang, Yi Liao
Summary: The downregulation of miR-383 leads to increased expression of RBM24 protein in lung adenocarcinoma cells, which activates chemotherapy resistance through NF-kappa B signaling pathway. The study provides potential therapeutic targets for clinical reversal of chemotherapy resistance in lung adenocarcinoma.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Genc
Summary: Ethyl pyruvate has anti-inflammatory and pro-metabolic effects, effectively suppressing NLRP3 inflammasome activation in microglial cells by regulating miR-223 and the NF-κB/HMGB1 axis.
Article
Immunology
Ning Li, Cheng Huang, Wei Chen, Zhengqing Li, Guoliang Hu, Guyue Li, Ping Liu, Ruiming Hu, Yu Zhuang, Junrong Luo, Xiaona Gao, Xiaoquan Guo
Summary: In this study, the interaction between NIBV and the host innate immune system of the kidney was explored. The results showed that NIBV infection caused kidney injury, including structural damage of renal tubules and bleeding. NIBV infection also upregulated the mRNA levels of TLR7, TRAF6, and IKK beta, while downregulating the protein levels of NF-kappa B P65. Additionally, NIBV infection induced the release of cytokines through the TLR7/NF-kappa B signaling axis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Ziyuan Wang, Xiaoting Sun, Yuanyuan Feng, Yang Wang, Lu Zhang, Yan Wang, Zhen Fang, Nisma Lena Bahaji Azami, Mingyu Sun, Qi Li
Summary: The study demonstrates that Dihydromyricetin (DMY) can restore chemosensitivity in colorectal cancer cells to oxaliplatin and vincristine by inhibiting MRP2 expression and its promoter activity. Additionally, DMY inhibits NF-kappa B/p65 expression, reducing its translocation to the nucleus and silencing Nrf2 signaling, resulting in decreased MRP2 expression. The combination of oxaliplatin and DMY shows a synergistic tumor suppression effect in vivo, suggesting NF-kappa B or Nrf2 as potential targets for CRC treatment.
Article
Biochemistry & Molecular Biology
Qi-xuan Kuang, Qing-zhou Li, Li-rong Lei, Yu-mei Wang, Li-jun Huang, Yi-Fei Dai, Wan Peng, Ming-zhi Zhang, Dong Wang, Yu-cheng Gu, Yun Deng, Da-le Guo
Summary: Three previously undescribed polyketides with anti-inflammatory activity were isolated from Fusarium proliferatum. The compounds attenuated inflammatory signal messengers and related proteins in lipopolysaccharide-induced macrophages. Transcriptome analysis and protein level experiments revealed the potential anti-inflammatory mechanism of the compounds involving NF-κB and MAPKs signaling pathways. Molecular docking models supported the inhibition of NF-κB and MAPK signaling by the compounds. These findings suggest that the compounds could be potential therapeutic candidates for inflammation-related diseases.
BIOORGANIC CHEMISTRY
(2022)
Review
Oncology
Yoshikazu Johmura, Alexsander Harris, Tomohiko Ohta, Makoto Nakanishi
Article
Multidisciplinary Sciences
David Tinaquero, Teresa Crespo-Garcia, Raquel G. Utrilla, Paloma Nieto-Marin, Andres Gonzalez-Guerra, Marcos Rubio-Alarcon, Anabel Camara-Checa, Maria Dago, Marcos Matamoros, Marta Perez-Hernandez, Maria Tamargo, Jorge Cebrian, Jose Jalife, Juan Tamargo, Juan Antonio Bernal, Ricardo Caballero, Eva Delpon
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Marta Roche-Molina, Bryn Hardwick, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M. Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A. Palma, Borja Ibanez, Grahame Mckenzie, Juan A. Bernal
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Jose A. Nicolas-Avila, Ana V. Lechuga-Vieco, Lorena Esteban-Martinez, Maria Sanchez-Diaz, Elena Diaz-Garcia, Demetrio J. Santiago, Andrea Rubio-Ponce, Jackson LiangYao Li, Akhila Balachander, Juan A. Quintana, Raquel Martinez-de-Mena, Beatriz Castejon-Vega, Andres Pun-Garcia, Paqui G. Traves, Elena Bonzon-Kulichenko, Fernando Garcia-Marques, Lorena Cusso, Noelia A-Gonzalez, Andres Gonzalez-Guerra, Marta Roche-Molina, Sandra Martin-Salamanca, Georgiana Crainiciuc, Gabriela Guzman, Jagoba Larrazabal, Elias Herrero-Galan, Jorge Alegre-Cebollada, Greg Lemke, Carla Rothlin, Luis Jesus Jimenez-Borreguero, Guillermo Reyes, Antonio Castrillo, Manuel Desco, Pura Munoz-Canoves, Borja Ibanez, Miguel Torres, Lai Guan Ng, Silvia G. Priori, Hector Bueno, Jesus Vazquez, Mario D. Cordero, Juan A. Bernal, Jose A. Enriquez, Andres Hidalgo
Article
Biology
Satoi Nagasawa, Yuta Kuze, Ichiro Maeda, Yasuyuki Kojima, Ai Motoyoshi, Tatsuya Onishi, Tsuguo Iwatani, Takamichi Yokoe, Junki Koike, Motohiro Chosokabe, Manabu Kubota, Hibiki Seino, Ayako Suzuki, Masahide Seki, Katsuya Tsuchihara, Eisuke Inoue, Koichiro Tsugawa, Tomohiko Ohta, Yutaka Suzuki
Summary: The study conducted a multi-omic analysis of ductal carcinoma in situ (DCIS) and identified age, gene amplification, and gene mutation as possible indicators of relapse. The results revealed heterogeneous cell populations in DCIS, providing predictive markers for classifying and optimizing treatment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andres Gonzalez-Guerra, Marta Roche-Molina, Nieves Garcia-Quintans, Cristina Sanchez-Ramos, Daniel Martin-Perez, Mariya Lytvyn, Javier de Nicolas-Hernandez, Jose Rivera-Torres, Diego F. Arroyo, David Sanz-Rosa, Juan A. Bernal
Summary: Elevated blood pressure, even within a physiological range, may contribute to atherosclerotic plaque development, as demonstrated in a new mouse model using AAV gene transfer technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoshitaka Sakamoto, Suzuko Zaha, Satoi Nagasawa, Shuhei Miyake, Yasuyuki Kojima, Ayako Suzuki, Yutaka Suzuki, Masahide Seki
Summary: This method combines long-read sequencing technology with enzymatic base conversion to provide high-resolution DNA methylation information. It has high applicability for intractable specimens for methylation analysis and can reveal the methylation status of key genes on chromosomes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernandez-Mendivil, Angel Nunez, Cesar Porrero, Nuria Garcia-Magro, Pilar Negredo, Sergio Senar, Cristina Sanchez-Ramos, Juan A. Bernal, Alberto Rabano, Jeroen Hoozemans, Ana I. Casas, Manuela G. Lopez, Marta del Campo, Harald H. H. W. Schmidt
Summary: This study reveals that NOX4 plays a significant role in tauopathies. By modulating autophagy-lysosomal pathway, the absence of NOX4 reduces the accumulation of pathological tau, improves tauopathy, and prevents neurotoxicity and cognitive decline. This suggests that NOX4 could be a potential therapeutic target for tauopathies.
Article
Multidisciplinary Sciences
Taku Monjo, Masaru Koido, Satoi Nagasawa, Yutaka Suzuki, Yoichiro Kamatani
Summary: Spatial transcriptomics can enhance histological interpretations by predicting gene expression patterns in unmeasured regions and tissues. Researchers developed a deep learning model called DeepSpaCE, which accurately predicts gene expression using spatial transcriptome data and immunohistochemistry images. They also developed a semi-supervised version of DeepSpaCE, which improves imputation accuracy using unlabeled histology images.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata-Yanagimoto, Yumiko Imai, Kaori Nakayama-Hosoya, Ai Kawana-Tachikawa, Taketoshi Mizutani, Yutaka Suzuki
Summary: Immune responses vary between individuals and can be influenced by personal health histories and unique environmental conditions. In this study, a systematic time-lapse single-cell analysis was conducted to investigate immune-cell profiles of seven healthy individuals. The results revealed significant diversity in immune-cell composition between individuals, with daily fluctuations observed even within the same individual. These findings provide important background information to better understand individual immune responses in different environmental conditions.
LIFE SCIENCE ALLIANCE
(2022)
Article
Oncology
Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Summary: This study found that the effectiveness of sacituzumab govitecan, a promising drug for breast cancer, could be altered by concomitant treatment. Tamoxifen, in particular, may be a favorable agent for combined therapy.
Article
Cardiac & Cardiovascular Systems
Andres Pun-Garcia, Agustin Clemente-Moragon, Rocio Villena-Gutierrez, Monica Gomez, David Sanz-Rosa, Anabel Diaz-Guerra, Belen Prados, Juan Pablo Medina, Fermi Monto, Maria Dolores Ivorra, Cristina Marquez-Lopez, Alessandro Cannavo, Juan A. Bernal, Walter J. Koch, Valentin Fuster, Jose Luis de la Pompa, Eduardo Oliver, Borja Ibanez
Summary: This study suggests that beta 3AR overexpression may be beneficial in treating HF induced by AS, indicating a potential therapeutic strategy.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Oncology
Sara Lopez-Tarruella, Maria Del Monte-Millan, Marta Roche-Molina, Yolanda Jerez, Isabel Echavarria Diaz-Guardamino, Blanca Herrero Lopez, Salvador Gamez Casado, Ivan Marquez-Rodas, Enrique Alvarez, Maria Cebollero, Tatiana Massarrah, Inmaculada Ocana, Ainhoa Arias, Jose angel Garcia-Saenz, Fernando Moreno Anton, Clara Olier Garate, Diana Moreno Munoz, David Marrupe, Miguel angel Lara alvarez, Santos Enrech, Coralia Bueno Muino, Miguel Martin
Summary: This study compares molecular subtyping based on gene expression profiling with immunohistochemistry techniques for breast cancer classification. The results show suboptimal concordance between these two methods, which may lead to inappropriate treatment for some patients.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Immunology
Satoi Nagasawa, Yukie Kashima, Ayako Suzuki, Yutaka Suzuki
Summary: Even within the same type of cancer, the cells exhibit diversity and interact differently. Single-cell analysis methods have rapidly evolved to provide novel insights into the heterogeneity of cancer cells, leading to better understanding and potential treatment strategies.
INFLAMMATION AND REGENERATION
(2021)