Pharmacological inhibition of TLR4-NF-κB signaling by TAK-242 attenuates hydrocephalus after intraventricular hemorrhage

Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

(2021) Yang Zhou et al.   World Journal of Diabetes

The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis

(2021) Siavash Bolourani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury

(2020) Jason K. Karimy et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets

(2020) Jason K. Karimy et al.   Nature Reviews Neurology

Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage

(2020) Xiaoxiao Tan et al.   STROKE

Could SCGF-Beta Levels Be Associated with Inflammation Markers and Insulin Resistance in Male Patients Suffering from Obesity-Related NAFLD?

(2020) Giovanni Tarantino et al.   Diagnostics

Posthemorrhagic hydrocephalus development after germinal matrix hemorrhage: Established mechanisms and proposed pathways

(2019) Damon Klebe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Complex Clearance Mechanisms After Intraventricular Hemorrhage and rt-PA Treatment—a Review on Clinical Trials

(2019) Bert Bosche et al.   Translational Stroke Research

Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice

(2018) Donglai Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Innate immunity and Toll-like receptor signaling in the pathogenesis of scleroderma

(2018) Max Brown et al.   CURRENT OPINION IN RHEUMATOLOGY

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

(2018) Swati Bhattacharyya et al.   Frontiers in Immunology

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

(2017) Jason K Karimy et al.   NATURE MEDICINE

Intraventricular administration of urokinase as a novel therapeutic approach for communicating hydrocephalus

(2017) Zhou Feng et al.   Translational Research

Factors Associated with Clinical Outcomes in Patients with Primary Intraventricular Hemorrhage

(2017) Sang-Hoon Lee et al.   MEDICAL SCIENCE MONITOR

Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway

(2016) Yan Feng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

(2015) James P. McAllister et al.   JOURNAL OF NEUROSURGERY

The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease

(2015) Michael Schuliga   MEDIATORS OF INFLAMMATION

Chronic Hydrocephalus and Perihematomal Tissue Injury Developed in a Rat Model of Intracerebral Hemorrhage with Ventricular Extension

(2014) Qianwei Chen et al.   Translational Stroke Research

Decorin prevents the development of juvenile communicating hydrocephalus

(2013) Hannah Botfield et al.   BRAIN

Delayed neurological deterioration after subarachnoid haemorrhage

(2013) R. Loch Macdonald   Nature Reviews Neurology

Toll-Like Receptor 4 Antagonist Attenuates Intracerebral Hemorrhage–Induced Brain Injury

(2013) Yan-Chun Wang et al.   STROKE

Subarachnoid Hemorrhage-Induced Hydrocephalus in Rats

(2012) Shuichi Okubo et al.   STROKE

Inflammation of the Choroid Plexus and Ependymal Layer of the Ventricle Following Intraventricular Hemorrhage

(2011) Philippe F. Simard et al.   Translational Stroke Research

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Randomized, double-blind, placebo-controlled, pilot trial of high-dose methylprednisolone in aneurysmal subarachnoid hemorrhage

(2009) Philippe Gomis et al.   JOURNAL OF NEUROSURGERY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?

(2008) Giovanni Tarantino et al.   Journal of Translational Medicine