Article
Medicine, Research & Experimental
Minmin Ji, Yuesheng Lv, Chaoqun Chen, Dingya Xing, Chao Zhou, Jinyao Zhao, Yangfan Qi, Jinrui Zhang, Yang Wang, Xiang Ma, Wei Xu, Wenjing Zhang, Xiaojie Li
Summary: This study found that metformin can inhibit the proliferation and migration of oral squamous cell carcinoma by regulating RNA alternative splicing, especially the splicing of the NUBP2 gene, which inhibits cancer cell proliferation.
Article
Multidisciplinary Sciences
Xiaoxu Li, Juan Fang, Xiaoan Tao, Juan Xia, Bin Cheng, Yun Wang
Summary: Oral squamous cell carcinoma (OSCC) is a common tumor with poor prognosis. The study reveals that Keratin 4 (KRT4) suppresses OSCC development but its downregulation mechanism is unknown. The m6A RNA methylation prevents intron splicing of KRT4 pre-mRNA in OSCC, leading to its downregulation.
Article
Biochemistry & Molecular Biology
Rong Jia, Xiaoxuan Che, Jun Jia, Jihua Guo
Summary: The study revealed that FOXM1a reduces cell proliferation and tumor formation in oral squamous cell carcinoma, regulated by exon 9 splicing and hnRNP C. This discovery uncovers a novel regulatory mechanism of oncogene FOXM1 expression in OSCC.
Review
Oncology
Miaomiao Liu, Jihua Guo, Rong Jia
Summary: Alternative RNA splicing is an important cellular process that, when dysregulated, contributes to cancer development. Dysregulated expression of splicing factors is involved in oral squamous cell carcinoma. Therapeutic approaches targeting RNA splicing are being developed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Karolina Golabek, Grzegorz Raczka, Jadwiga Gazdzicka, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Lukasz Krakowczyk, Dorota Hudy, Marek Asman, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study is the first to investigate the association between LTF gene polymorphisms and the risk of oral squamous cell carcinoma (OSCC), as well as its influence on TNM staging and histological grading. The G/G genotype of rs2073495 and rs4637321 were found to be associated with an increased risk of OSCC. However, no significant influences were observed between LTF genotype and TNM staging or histological grading.
Article
Dentistry, Oral Surgery & Medicine
Yong Cheng, Le Shi, YouCheng Yu
Summary: In this study, the expression profiles of circRNAs in oral squamous cell carcinoma (OSCC) were explored using high-throughput microarray. The results revealed differentially expressed circRNAs in OSCC tissues compared to adjacent tissues. Further analysis identified potential molecular mechanisms involving circRNA-miRNA-mRNA interactions, as well as the involvement of target genes in various signaling pathways. These findings suggest that circRNAs may play a vital role in the tumorigenesis and development of OSCC.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li, Bingli Wu
Summary: This study identified significant differentially expressed alternative splicing (AS) events between ESCC and normal tissues, with a focus on processes related to pro-metastasis cell junction and migration. The upregulated splicing factor SF3B4 was highlighted as a potential prognostic factor of ESCC.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Yuancheng Li, Linnan Gong, Na Qin, Xiaoyu Wei, Limin Miao, Hua Yuan, Cheng Wang, Hongxia Ma
Summary: CircRNAs exhibit a global down-regulation pattern in oral squamous cell carcinoma tissues, with regulation of genes primarily involved in immune and extracellular matrix pathways. These circRNAs could serve as potential prognostic biomarkers for OSCC.
Article
Oncology
Boxue He, Cong Wei, Qidong Cai, Pengfei Zhang, Shuai Shi, Xiong Peng, Zhenyu Zhao, Wei Yin, Guangxu Tu, Weilin Peng, Yongguang Tao, Xiang Wang
Summary: This study evaluated AS-based biomarkers for lung squamous cell carcinoma (LUSC) patients using machine learning algorithms. Through data analysis, AS events related to LUSC were identified, and a LNM classifier and prognostic model were built. Validation experiments confirmed the reliability of these events.
CANCER CELL INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Genetics & Heredity
Min Chen, Rui Zhu, Fangzhou Zhang, Liucun Zhu
Summary: This study proposed an analysis method based on synergy to screen key factors that regulate the initiation and progression of lung squamous cell carcinoma (LUSC), and validated the method's effectiveness and accuracy through TCGA and cross-platform GEO datasets.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Article
Oncology
Le Xu, Qingdang Li, Yifei Wang, Lin Wang, Yuxing Guo, Rong Yang, Na Zhao, Na Ge, Yixiang Wang, Chuanbin Guo
Summary: The study found that METTL3 enhances the mRNA stability of SLC7A11 via m(6)A-mediated binding of IGF2BP2, promoting the progression of oral squamous cell carcinoma (OSCC). Triptolide suppresses OSCC by inhibiting the METTL3-SLC7A11 axis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Dehua Hu, Yufeng Cai, Lan He, Hao Jiang
Summary: In this study, a ceRNA network was established to explore the relationship between circRNA and immune infiltration in oral squamous cell carcinoma. The study identified potential biomarkers and established a prognostic model based on clinical risk. The findings help to uncover the pathogenesis of this type of cancer.
Editorial Material
Oncology
Pravin Kesarwani, Krishnamurthy Thyagarajan, Shilpak Chatterjee, Viswanathan Palanisamy, Shikhar Mehrotra
Article
Oncology
Anirban Banerjee, Krishnamurthy Thyagarajan, Shilpak Chatterjee, Paramita Chakraborty, Pravin Kesarwani, Myroslawa Soloshchenko, Mazen Al-Hommrani, Kristina Andrijauskaite, Kelly Moxley, Harinarayanan Janakiraman, Matthew J. Scheffel, Kristi Helke, Kent Armenson, Viswanathan Palanisamy, Mark P. Rubinstein, Elizabeth-Garrett Mayer, David J. Cole, Chrystal M. Paulos, Christina Voelkel-Johnson, Michael I. Nishimura, Shikhar Mehrotra
Article
Genetics & Heredity
Mrinmoyee Majumder, Reniqua House, Nallasivam Palanisamy, Shuo Qie, Terrence A. Day, David Neskey, J. Alan Diehl, Viswanathan Palanisamy
Article
Biochemistry & Molecular Biology
Hong Yu, Yuhao Sun, Courtney Haycraft, Viswanathan Palanisamy, Keith L. Kirkwood
Article
Biochemistry & Molecular Biology
Sudha Talwar, Junfei Jin, Brittany Carroll, Angen Liu, Marion Boyd Gillespie, Viswanathan Palanisamy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Sudha Talwar, Reniqua House, Santhanalakshmi Sundaramurthy, Sundaravadivel Balasubramanian, Hong Yu, Viswanathan Palanisamy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Review
Dentistry, Oral Surgery & Medicine
V. Palanisamy, A. Jakymiw, E. A. Van Tubergen, N. J. D'Silva, K. L. Kirkwood
JOURNAL OF DENTAL RESEARCH
(2012)
Article
Chemistry, Multidisciplinary
Shivani Sharma, Boyd M. Gillespie, Viswanathan Palanisamy, James K. Gimzewski
Article
Multidisciplinary Sciences
Viswanathan Palanisamy, Shivani Sharma, Amit Deshpande, Hui Zhou, James Gimzewski, David T. Wong
Article
Biochemistry & Molecular Biology
Sudha Talwar, Sundaravadivel Balasubramanian, Santhanalakshmi Sundaramurthy, Reniqua House, Carol J. Wilusz, Dhandapani Kuppuswamy, Nisha D'Silva, Marion Boyd Gillespie, Elizabeth Goodwin Hill, Viswanathan Palanisamy
Review
Cell Biology
Saraswathi Ramachandran, Viswanathan Palanisamy
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2012)
Article
Genetics & Heredity
Mrinmoyee Majumder, Viswanathan Palanisamy
Review
Biochemistry & Molecular Biology
Mrinmoyee Majumder, Roger H. Johnson, Viswanathan Palanisamy
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen, Michael C. Ostrowski, Wenjian Gan
Summary: AKT is involved in key cellular processes, and arginine methylation by PRMT5 promotes AKT activity and tumorigenesis.
NATURE COMMUNICATIONS
(2021)