Review
Plant Sciences
Jiao Wang, Neeraj Rani, Seema Jakhar, Rakesh Redhu, Sanjiv Kumar, Sachin Kumar, Sanjeev Kumar, Bhagwati Devi, Jesus Simal-Gandara, Bairong Shen, Rajeev K. Singla
Summary: This article reviews the anticancer properties of Opuntia ficus-indica (L.) Mill. and its potential as a natural cancer prevention and treatment agent. The study highlights the mechanisms involved, such as apoptosis, cell cycle arrest, and Bcl-2 modulation. However, further research is needed to determine the clinical utility of this resource.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Abeer S. Alqurashi, Luluah M. Al Masoudi, Hamida Hamdi, Abeer Abu Zaid
Summary: This study evaluated the chemical characteristics of Opuntia ficus-indica seed oil from Taif, Kingdom of Saudi Arabia, and assessed its antioxidant, antiviral, antifungal, antibacterial, and anticancer activities. Results showed that the oil contained high levels of linolenic acid and tocopherols, and exhibited significant antimicrobial, anticancer, and antiviral effects. These findings suggest that Opuntia ficus-indica seed oil has potential as a beneficial candidate for non-communicable disease management.
Article
Chemistry, Physical
P. Lalitha, Sugumari Vallinayagam, Kaushik Pal, A. Sinthiya, Suganya Ramar
Summary: In this study, a single crystal of sodium nitrate doped with acetamide (NAAC) was grown and characterized by various analyses such as XRD, FT-IR, and UV-Visible Spectral analysis. The crystal demonstrated wide transparency range and mechanical strength, with its morphology analyzed through etching studies. Additionally, the crystal's antioxidant, antidiabetic, and anticancer activities were also evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Food Science & Technology
Nadia Palmieri, Alessandro Suardi, Walter Stefanoni, Luigi Pari
Summary: The study found that education level plays a significant role in the perception of functional pasta. Well-educated individuals had different perceptions compared to those with lower education levels. The results also showed that respondents were interested in the health benefits and nutritional aspects of the functional pasta, which could encourage acceptance and consumption of this new food product. Additionally, respondent preferences for pasta with Opuntia may also be influenced by its price.
Review
Polymer Science
Muhammad Azeem, Muhammad Hanif, Khalid Mahmood, Nabeela Ameer, Fazal Rahman Sajid Chughtai, Usman Abid
Summary: Flavonoids, such as quercetin, are powerful natural antioxidants and cytotoxic compounds found in many fruits and vegetables. A recent review highlighted the various roles of quercetin in the medical field, including antioxidant, antimicrobial, antidiabetic, anticancerous, and anti-inflammatory effects. The review also discussed the use of quercetin complexes in drug delivery systems and therapeutic interventions.
Article
Chemistry, Physical
Faiza Asghar, Shamsa Munir, Saira Fatima, Babar Murtaza, Jahangeer Patujo, Amin Badshah, Ian S. Butler, Muhammad Babar Taj, Muhammad Nawaz Tahir
Summary: The synthesis and characterization of ferrocene-integrated anilines showed significant biological activity potential. These derivatives exhibited notable free radical scavenging activity, modest cytotoxicity against cancer cells, and potential inhibition of alpha-amylase, along with fewer toxic effects in normal cells. The study also revealed a close agreement between computational and experimental measurements, indicating the potential applications of these newly synthesized compounds in various medical fields.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Agriculture, Multidisciplinary
Hao Zhong, Abdullah, Minjie Zhao, Jun Tang, Lingli Deng, Fengqin Feng
Summary: Fermentation using different starters significantly improved the physicochemical, antioxidant, antimicrobial, and antidiabetic properties of blueberry juices. Probiotic-fermented juices exhibited higher organic acids, antioxidant potential, antibacterial activities, and alpha-glucosidase inhibitory activity. Promising potential was shown in enhancing glucose bio-utilization for antihyperglycemic effects.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Review
Biochemistry & Molecular Biology
Fabian Fernandez-Luqueno, Gabriela Medina-Perez, Elizabeth Perez-Soto, Salvador Espino-Manzano, Laura Peralta-Adauto, Sergio Perez-Rios, Rafael Campos-Montiel
Summary: Xoconostle fruits are rich in ascorbic acid, betalains, phenols, tannins, and flavonoids, which exhibit antioxidant, antibacterial, anti-inflammatory, and hepatoprotective gastroprotective activities. Stability of fruit extracts can be evaluated through in vitro assays, and encapsulated extracts can be applied in various food matrices to enhance consumer health.
Article
Nutrition & Dietetics
Marina Murillo-Villicana, Ruth Noriega-Cisneros, Donovan J. Pena-Montes, Maribel Huerta-Cervantes, Asdrubal Aguilera-Mendez, Christian Cortes-Rojo, Rafael Salgado-Garciglia, Rocio Montoya-Perez, Hector Riveros-Rosas, Alfredo Saavedra-Molina
Summary: EJS has the potential to reduce blood glucose levels and weight, improve lipid profile and liver function, and inhibit oxidative stress in rats with streptozotocin-induced diabetes.
Article
Food Science & Technology
Wonju Song, Venus Lagmay, Beom-Gyun Jeong, Jiyoung Jung, Jiyeon Chun
Summary: This study demonstrates that fermentation with selected LAB and cellulolytic enzymes can modulate the physical and functional properties of O. humifusa extract. Extracts containing cellulolytic enzymes showed lower viscosity and higher yield, while fermentation process enhanced the total polyphenol content and antioxidant activity. Furthermore, flavonoid glycosides were effectively converted to aglycones during fermentation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Yaotong Liu, Yuanyuan Bian, Yan Bai, Siqi Yu, Yuxuan Tian, Jie Li, Suhong Li, Tuoping Li
Summary: Potato protease inhibitors (PPIs), derived from potato protein isolate, have excellent safety, nutritional value, and a promising market potential. Cell-based assays have shown that PPIs possess antioxidative and anticancer properties. PPIs at a concentration of 5 mg/mL demonstrated a peroxyl radical scavenging value of (2,119 +/- 204) mg VCE/100 g, and cellular antioxidant activity values of (45.83 +/- 3.5) (no PBS wash) and (33.25 +/- 4.4) mu mol QE/100 g (PBS wash). Pre-treatment with PPIs prevented oxidative damage, inhibited morphological changes, and exhibited selective anti-proliferative effects on GIST882 cells (IC50 = (10.53 +/- 3.87) mg/mL). PPIs also showcased potent inhibition of cancer cell growth, migration, and invasion. These findings support the potential usage of PPIs as functional foods for preventing oxidative damage and cancer.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Food Science & Technology
El Hassania Loukili, Btissam Bouchal, Mohamed Bouhrim, Farid Abrigach, Manon Genva, Kahina Zidi, Mohamed Bnouham, Mohammed Bellaoui, Belkheir Hammouti, Mohamed Addi, Mohammed Ramdani, Marie-Laure Fauconnier
Summary: The study investigated the chemical composition of ethanolic extracts from Opuntia dillenii fruits collected in Morocco, revealing high quantities of polyphenols with antibacterial, antifungal, and antidiabetic activities. The peel extracts showed the greatest inhibitory effects on alpha-glucosidase and alpha-amylase activities. Molecular docking simulations indicated the presence of bioactive compounds in the extract with a better potential to decrease the enzyme activity than the commercial drug acarbose.
JOURNAL OF FOOD QUALITY
(2022)
Article
Food Science & Technology
Zhenxing Wang, Zongcai Tu, Xing Xie, Hao Cui, Kin Weng Kong, Lu Zhang
Summary: The study demonstrated that the ethyl acetate fraction of P. frutescens leaf contains high levels of phenolic and flavonoid compounds, exhibits excellent antioxidant and alpha-glucosidase inhibitory activities, and shows significant hypoglycemic effects in streptozotocin-induced diabetic rats by modulating physiological indicators and improving organ tissue conditions.
Article
Food Science & Technology
Ghanya Al-Naqeb, Cinzia Cafarella, Eugenio Aprea, Giovanna Ferrentino, Alessandra Gasparini, Chiara Buzzanca, Giuseppe Micalizzi, Paola Dugo, Luigi Mondello, Francesca Rigano
Summary: This study evaluated the potential of supercritical fluid extraction (SFE) as a green alternative to Soxhlet extraction for obtaining oils from Opuntia ficus-indica (OFI) and Opuntia dillenii (OD) seeds. SFE with specific parameters produced oils rich in unsaturated fatty acids and tocopherols. The highest yield was achieved through Soxhlet extraction, and the most abundant fatty acid in all samples was linoleic acid. SFE of OFI seeds from Yemen resulted in the highest gamma-tocopherol content. Overall, SFE demonstrated its suitability for producing oils with potential applications in functional food and nutraceutical products.
Article
Integrative & Complementary Medicine
Ahmad M. Eid, Mohammed Hawash
Summary: The study found that safrole oil has antioxidant and antidiabetic activities, influenced by safrole nanoemulgel; Safrole oil showed antimicrobial and anticancer activities, which were improved with the help of nanoemulgel.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Biochemical Research Methods
Aishma Khattak, Bashir Ahmad, Abdur Rauf, Sami Bawazeer, Umar Farooq, Jawad Ali, Seema Patel, Eman Ramadan EI-Sharkawy, Rabia Ikram, Huang Linfang
IET NANOBIOTECHNOLOGY
(2019)
Review
Biotechnology & Applied Microbiology
Seema Patel, Ahmad Homaei, Sangram Patil, Achlesh Daverey
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Article
Chemistry, Applied
Tareq Abu-Izneid, Abdur Rauf, Muhammad Saleem, Nashwa Mansour, Mohamed I. S. Abdelhady, Munjed M. Ibrahim, Seema Patel
NATURAL PRODUCT RESEARCH
(2020)
Review
Medicine, Research & Experimental
Damini Kothari, Seema Patel, Soo-Ki Kim
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Immunology
Rashmi Kumariya, Anita Kumari Garsa, Y. S. Rajput, S. K. Sood, Nadeem Akhtar, Seema Patel
MICROBIAL PATHOGENESIS
(2019)
Review
Chemistry, Medicinal
Kannan R. R. Rengasamy, Haroon Khan, Imad Ahmad, Devina Lobine, Fawzi Mahomoodally, Shanoo Suroowan, Sherif T. S. Hassan, Suowen Xu, Seema Pater, Maria Daglia, Seyed Mohammad Nabavi, Shunmugiah Karutha Pandian
MEDICINAL RESEARCH REVIEWS
(2019)
Review
Food Science & Technology
Seema Patel, Hafiz Ansar Rasul Suleria, Abdur Rauf
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2019)
Review
Food Science & Technology
Shaden A. M. Khalifa, Mohamed A. Farag, Nermeen Yosri, Jamal S. M. Sabir, Aamer Saeed, Saleh Mohammed Al-Mousawi, Wafaa Taha, Syed Ghulam Musharraf, Seema Patel, Hesham R. El-Seedi
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2019)
Review
Green & Sustainable Science & Technology
Seema Patel, Ahmad Homaei, Sana Sharifian
Summary: Synthetic fragrance compounds, commonly used in household cleaning products and personal care items, have been shown to have detrimental effects on human health, including causing various pathologies and disrupting the endocrine system. The link between fragrance compounds and widespread modern lifestyle diseases is not well understood by the majority of the public, highlighting the need for further investigation and awareness about the potential dangers associated with these compounds.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2021)
Article
Oncology
Abdur Rauf, Ajmal Khan, Tareq Abu-Izneid, Fahad A. Alhumaydhi, Saud Bawazeer, Muslim Raza, Haroon Khan, Seema Patel, Ahmed Al-Harrasi
Summary: The two known dimeric napthoquiones, diospyrin and 8-hydroxydiospyrin, isolated from the roots of Diospyros lotus, demonstrated significant anti-tumor, anti-carcinogenic, and multidrug resistance reversal effects, as well as significant attenuation of thermal-induced denaturation of proteins.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemical Research Methods
Bashir Ahmad, Farah Shireen, Abdur Rauf, Mohammad Ali Shariati, Shumaila Bashir, Seema Patel, Ajmal Khan, Maksim Rebezov, Muhammad Usman Khan, Mohammad S. Mubarak, Haiyuan Zhang
Summary: Studies have shown that plant materials can be used to produce biocompatible silver nanoparticles, but their characteristics depend on reaction conditions. These silver particles have diverse applications in medical and material fields, but their ecotoxicity remains a challenge.
IET NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sami Bawazeer, Abdur Rauf, Yahia N. Mabkhot, Salim S. Al-Showiman, Seema Patel, Somia Gul, Muslim Raza, Joseph Molnar, Diana Szabo, Akos Csonka, Mujeeb-ur-Rehman, Mohammad S. Mubarak, Gokhan Zengin, Mohamed Fawzy Ramadan
Summary: This study focused on isolating bioactive compounds from Pistacia integerrima found in South Asia, which showed significant multidrug resistance reversing effects on mouse lymphoma cell lines. In silico molecular docking investigations revealed interactions between the compounds and P-glycoprotein, indicating potential for the discovery of novel inhibitors for cancer treatment.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2021)
Article
Toxicology
Naveed Muhammad, Sana Ullah, Abdur Rauf, Muhammad Atif, Seema Patel, Muhammad Israr, Sajid Akbar, Omer Shehzad, Muhammad Saeed, Saud Bawazeer, Md. Sahab Uddin, Marina Derkho, Mohammad Ali Shariati, Mohammad S. Mubarak
Summary: The study showed that the juice, aqueous, and methanol extract of C. reflexa exhibit significant anti-motility and anti-secretory potential, explaining the medicinal use of C. reflexa as an antidiarrheal medicinal plant in folk medicine.
TOXICOLOGY REPORTS
(2021)
Article
Biology
Abdur Rauf, Saud Bawazeer, Muslim Raza, Eman El-Sharkawy, Md Habibur Rahman, Mohamed A. El-Esawi, Ghias Uddin, Bina S. Siddiqui, Anees Ahmed Khalil, Joseph Molnar, Akos Csonka, Diana Szabo, Haroon Khan, Mohammad S. Mubarak, Taibi Ben Hadda, Mudyawati Kamaruddin, Seema Patel
Summary: The bioactive triterpenoid 3-oxo-6-beta-hydroxy-beta-amyrin has been isolated from Pistacia integerrima and shown to have potential for reversing multidrug resistance and inhibiting tumor promotion. Molecular docking analysis indicated good interaction of the compound with target receptors, supporting its use as a potential anticancer agent.
Article
Pharmacology & Pharmacy
S. Bawazeer, A. Rauf, A. Shahidullah, A. P. Mishra, I. Faraone, L. Milella, K. Ullah, G. Uddin, I. Khan, S. Patel, Z. A. Shah
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)