LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Identification of low molecular weight nuclear complexes containing integrase during the early stages of HIV-1 infection

(2013) Annabelle Gérard et al.   Retrovirology

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Saquinavir Inhibits Early Events Associated with Establishment of HIV-1 Infection: Potential Role for Protease Inhibitors in Prevention

(2012) Martha Stefanidou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

(2012) Frauke Christ et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel therapeutic strategies targeting HIV integrase

(2012) Peter K Quashie et al.   BMC Medicine

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

(2012) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

(2012) Jacques J. Kessl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

(2012) Frauke Christ et al.   VIROLOGY

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

(2012) Rik Schrijvers et al.   PLoS Pathogens

Allosteric Inhibitor Development Targeting HIV-1 Integrase

(2011) Laith Q. Al-Mawsawi et al.   ChemMedChem

In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75

(2011) Melissa McNeely et al.   JOURNAL OF MOLECULAR BIOLOGY

Timing of the Components of the HIV Life Cycle in Productively Infected CD4+ T Cells in a Population of HIV-Infected Individuals

(2011) J. M. Murray et al.   JOURNAL OF VIROLOGY

LEDGF Dominant Interference Proteins Demonstrate Prenuclear Exposure of HIV-1 Integrase and Synergize with LEDGF Depletion To Destroy Viral Infectivity

(2011) A. M. Meehan et al.   JOURNAL OF VIROLOGY

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

HIV-1 Gag Processing Intermediates Trans-dominantly Interfere with HIV-1 Infectivity

(2009) Barbara Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

Residues in the HIV-1 Capsid Assembly Inhibitor Binding Site Are Essential for Maintaining the Assembly-competent Quaternary Structure of the Capsid Protein

(2008) Vanda Bartonova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE

HIV-1 Pre-Integration Complexes Selectively Target Decondensed Chromatin in the Nuclear Periphery

(2008) Alberto Albanese et al.   PLoS One