Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Correlation of Recombinant Integrase Activity and Functional Preintegration Complex Formation during Acute Infection by Replication-Defective Integrase Mutant Human Immunodeficiency Virus

(2012) X. Li et al.   JOURNAL OF VIROLOGY

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

(2011) Jacques J. Kessl et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A new functional role of HIV-1 integrase during uncoating of the viral core

(2010) Marisa S. Briones et al.   IMMUNOLOGIC RESEARCH

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

Structure-based modeling of the functional HIV-1 intasome and its inhibition

(2010) L. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

(2009) Fabrice Michel et al.   EMBO JOURNAL

Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex

(2009) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

(2009) J. J. Kessl et al.   MOLECULAR PHARMACOLOGY

A novel method for determining the inhibitory potential of anti-HIV drugs

(2009) Lin Shen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

(2008) I. Malet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

(2008) Christopher J. McKee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE