New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Published 2012 View Full Article
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Title
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 25, Pages 21189-21203
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2012-04-26
DOI
10.1074/jbc.m112.347534
References
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Related references
Note: Only part of the references are listed.- Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
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- Dithiothreitol Causes HIV-1 Integrase Dimer Dissociation While Agents Interacting With the Integrase Dimer Interface Promote Dimer Formation
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- Allosteric Inhibitor Development Targeting HIV-1 Integrase
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- FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
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- Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
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- Resistance to Integrase Inhibitors
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- Sustained Antiretroviral Effect of Raltegravir After 96 Weeks of Combination Therapy in Treatment-Naive Patients With HIV-1 Infection
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- Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
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- (2009) J. J. Kessl et al. MOLECULAR PHARMACOLOGY
- Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase1
- (2008) Li DU et al. ACTA PHARMACOLOGICA SINICA
- Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro
- (2008) I. Malet et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeficiency Virus Type 1 Integrase
- (2008) G. S. Jones et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75
- (2008) Li Du et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anti-infectives Clinical progress of HIV-1 integrase inhibitors
- (2008) Laith Q Al-Mawsawi et al. EXPERT OPINION ON EMERGING DRUGS
- Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein
- (2008) Christopher J. McKee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyrtiosal, from the Marine SpongeHyrtios erectus, Inhibits HIV-1 Integrase Binding to Viral DNA by a New Inhibitor Binding Site
- (2007) Li Du et al. ChemMedChem
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