Proteases and proteomics: Cutting to the core of human skin pathologies

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome

(2014) Laetitia Furio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low Expression of the IL-23/Th17 Pathway in Atopic Dermatitis Compared to Psoriasis

(2014) E. Guttman-Yassky et al.   JOURNAL OF IMMUNOLOGY

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

(2013) Stefan Tholen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis

(2013) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

(2013) David Ellinghaus et al.   NATURE GENETICS

Acral Peeling Skin Syndrome Resulting from a Homozygous Nonsense Mutation in theCSTAGene Encoding Cystatin A

(2013) Aleksandar L. Krunic et al.   PEDIATRIC DERMATOLOGY

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation

(2013) U. auf dem Keller et al.   Science Signaling

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rhomboid proteins: a role in keratinocyte proliferation and cancer

(2012) Sarah L. Etheridge et al.   CELL AND TISSUE RESEARCH

Matrix metalloproteinases and epidermal wound repair

(2012) Vera L. Martins et al.   CELL AND TISSUE RESEARCH

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis

(2012) P. Fortugno et al.   HUMAN MOLECULAR GENETICS

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

(2012) Claus-Werner Franzke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis

(2012) Mayte Suárez-Fariñas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

(2012) Michelle Janssens et al.   JOURNAL OF LIPID RESEARCH

The identification of a new role for LEKTI in the skin: The use of protein ‘bait’ arrays to detect defective trafficking of dermcidin in the skin of patients with Netherton syndrome

(2012) Kate Bennett et al.   Journal of Proteomics

Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome

(2012) Stefan Tholen et al.   MOLECULAR & CELLULAR PROTEOMICS

Global identification of peptidase specificity by multiplex substrate profiling

(2012) Anthony J O'Donoghue et al.   NATURE METHODS

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

(2011) S. Kezic et al.   ALLERGY

Mutations in CSTA, Encoding Cystatin A, Underlie Exfoliative Ichthyosis and Reveal a Role for This Protease Inhibitor in Cell-Cell Adhesion

(2011) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization

(2011) Carolyn J. Broccardo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distribution and Expression of Non-Neuronal Transient Receptor Potential (TRPV) Ion Channels in Rosacea

(2011) Mathias Sulk et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rosacea as a Disease of Cathelicidins and Skin Innate Immunity

(2011) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

(2011) Martin Steinhoff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Neurovascular and Neuroimmune Aspects in the Pathophysiology of Rosacea

(2011) Verena D. Schwab et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

(2011) Christoph Becker-Pauly et al.   MOLECULAR & CELLULAR PROTEOMICS

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acral Peeling Skin Syndrome: A Clinically and Genetically Heterogeneous Disorder

(2011) Sasha Pavlovic et al.   PEDIATRIC DERMATOLOGY

Integrated network analysis of transcriptomic and proteomic data in psoriasis

(2010) Eleonora Piruzian et al.   BMC Systems Biology

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models

(2010) Johann E. Gudjonsson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes

(2010) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

New Role for LEKTI in Skin Barrier Formation: Label-Free Quantitative Proteomic Identification of Caspase 14 as a Novel Target for the Protease Inhibitor LEKTI

(2010) Kate Bennett et al.   JOURNAL OF PROTEOME RESEARCH

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

(2010) Katiuchia Uzzun Sales et al.   NATURE GENETICS

Forty-two novelCOL7A1mutations and the role of a frequent single nucleotide polymorphism in theMMP1promoter in modulation of disease severity in a large European dystrophic epidermolysis bullosa cohort

(2009) J.S. Kern et al.   BRITISH JOURNAL OF DERMATOLOGY

Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4

(2009) Joakim E. Swedberg et al.   CHEMISTRY & BIOLOGY

Peeling off the layers: Skin taping and a novel proteomics approach to study atopic dermatitis

(2009) Carolyn J. Broccardo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

(2009) Emma Guttman-Yassky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular Dissection of Psoriasis: Integrating Genetics and Biology

(2009) James T. Elder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms

(2008) Peter M. Elias et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation

(2008) Michael D. Howell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing

(2008) Thomas Alef et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

A frequent functional SNP in theMMP1promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa

(2007) Matthias Titeux et al.   HUMAN MUTATION