Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

(2011) Stefan Tholen et al.   BIOLOGICAL CHEMISTRY

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

(2011) Oliver Schilling et al.   BIOLOGICAL CHEMISTRY

Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

(2011) Martin L. Biniossek et al.   JOURNAL OF PROTEOME RESEARCH

Integrated Proteomic Profiling of Cell Line Conditioned Media and Pancreatic Juice for the Identification of Pancreatic Cancer Biomarkers

(2011) Shalini Makawita et al.   MOLECULAR & CELLULAR PROTEOMICS

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

(2011) Oded Kleifeld et al.   Nature Protocols

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

(2011) Oliver Schilling et al.   Nature Protocols

Proteomic techniques and activity-based probes for the system-wide study of proteolysis

(2010) Ulrich auf dem Keller et al.   BIOCHIMIE

Impaired turnover of autophagolysosomes in cathepsin L deficiency

(2010) Julia Dennemärker et al.   BIOLOGICAL CHEMISTRY

WaveletQuant, an improved quantification software based on wavelet signal threshold de-noising for labeled quantitative proteomic analysis

(2010) Fan Mo et al.   BMC BIOINFORMATICS

Wnt signaling and senescence: A tug of war in early neoplasia?

(2010) Peter D. Adams et al.   CANCER BIOLOGY & THERAPY

Biological role of matrix metalloproteinases: a critical balance

(2010) S. Loffek et al.   EUROPEAN RESPIRATORY JOURNAL

Cathepsin X-deficient Gastric Epithelial Cells in Co-culture with Macrophages

(2010) Anja Bernhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

(2010) Anna Prudova et al.   MOLECULAR & CELLULAR PROTEOMICS

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

(2010) L Sevenich et al.   ONCOGENE

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

(2010) L. Sevenich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis of the secretome of TGF-β signaling-deficient mammary fibroblasts

(2010) Baogang J. Xu et al.   PROTEOMICS

Identification of Five Candidate Lung Cancer Biomarkers by Proteomics Analysis of Conditioned Media of Four Lung Cancer Cell Lines

(2009) Chris Planque et al.   MOLECULAR & CELLULAR PROTEOMICS

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

The Universal Protein Resource (UniProt) in 2010

(2009)   NUCLEIC ACIDS RESEARCH

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

(2008) Paige Snider et al.   CIRCULATION RESEARCH

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

(2008) O Vasiljeva et al.   ONCOGENE

Cysteine cathepsins: Cellular roadmap to different functions

(2007) Klaudia Brix et al.   BIOCHIMIE