The DAN family: Modulators of TGF-β signaling and beyond

Coco regulates dorsoventral specification of germ layers via inhibition of TGF  signalling

(2013) T. J. D. Bates et al.   DEVELOPMENT

Identification and expression analysis of BMP signaling inhibitors genes of the DAN family in amphioxus

(2013) Yann Le Petillon et al.   GENE EXPRESSION PATTERNS

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

(2013) J. Ke et al.   GENES & DEVELOPMENT

Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE−/−Mice

(2013) Iris Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-functional norrin is a ligand for the LGR4 receptor

(2013) C. Deng et al.   JOURNAL OF CELL SCIENCE

Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition

(2013) Verena Boschert et al.   PLoS One

Structure of Protein Related to Dan and Cerberus: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism

(2013) Kristof Nolan et al.   STRUCTURE

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

(2013) J A Tamminen et al.   Oncogenesis

Involvement of αvβ3 integrin in gremlin-induced angiogenesis

(2012) Cosetta Ravelli et al.   ANGIOGENESIS

DAN (NBL1) Specifically Antagonizes BMP2 and BMP4 and Modulates the Actions of GDF9, BMP2, and BMP4 in the Rat Ovary1

(2012) Wei-Ting Hung et al.   BIOLOGY OF REPRODUCTION

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors

(2012) Gill Holdsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors

(2012) Ming-Huang Chen et al.   JOURNAL OF GASTROENTEROLOGY

Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers

(2012) Chandramohan Kattamuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of Nanomechanics in Canonical and Noncanonical Pro-angiogenic Ligand/VEGF Receptor-2 Activation

(2012) Daniele Maiolo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors/antagonists of TGF-  system in kidney fibrosis

(2012) M. Yanagita   NEPHROLOGY DIALYSIS TRANSPLANTATION

Gremlin is Overexpressed in Lung Adenocarcinoma and Increases Cell Growth and Proliferation in Normal Lung Cells

(2012) Michael S. Mulvihill et al.   PLoS One

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

(2012) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and purification of recombinant protein related to DAN and cerberus (PRDC)

(2012) Chandramohan Kattamuri et al.   PROTEIN EXPRESSION AND PURIFICATION

Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-β Antagonist, Controls Early Neuroectoderm Specification in Xenopus

(2012) Suhong Xu et al.   PLOS BIOLOGY

Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin

(2011) Paola Chiodelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left–right asymmetry in the chick embryo

(2011) Kenjiro Katsu et al.   DEVELOPMENTAL BIOLOGY

Structure of Myostatin·Follistatin-like 3

(2011) Jennifer N. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Secreted BMP Antagonist, Cer1, Fine Tunes the Spatial Organization of the Ureteric Bud Tree during Mouse Kidney Development

(2011) Lijun Chi et al.   PLoS One

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Bone Morphogenetic Proteins: A critical review

(2010) Beth Bragdon et al.   CELLULAR SIGNALLING

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

(2010) Carola Krause et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

(2010) David W. Walsh et al.   TRENDS IN CELL BIOLOGY

Role of Gremlin in the Lung

(2009) Christine M. Costello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bone morphogenetic protein-7 and Gremlin: New emerging therapeutic targets for diabetic nephropathy

(2009) Yanling Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NMR structure of the Wnt modulator protein Sclerostin

(2009) Stella E. Weidauer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

(2009) Jennifer N Cash et al.   EMBO JOURNAL

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

(2009) Jose A. Belo et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals

(2009) Katherine B. Lintern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

TGFβ in Cancer

(2008) Joan Massagué   CELL

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding

(2008) Jin-li Zhang et al.   DEVELOPMENTAL CELL

Cerberus functions as a BMP agonist to synergistically inducenodalexpression during left-right axis determination in the chick embryo

(2008) Xueyan Yu et al.   DEVELOPMENTAL DYNAMICS

Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro

(2008) Hisashi Ideno et al.   EXPERIMENTAL CELL RESEARCH

The Structure of FSTL3·Activin A Complex

(2008) Robin Stamler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt Signaling

(2008) Peter ten Dijke et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development

(2008) Atsushi Ohazama et al.   PLoS One

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

(2007) M. Tanaka et al.   KIDNEY INTERNATIONAL