Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition

Systemic Administration of Sclerostin Antibody Enhances Bone Repair in a Critical-Sized Femoral Defect in a Rat Model

(2013) Mandeep S. Virk et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

(2013) Maarten van Dinther et al.   PLoS One

Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors

(2012) Gill Holdsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin

(2012) J. W. Back et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

(2011) Victoria E. Ahn et al.   DEVELOPMENTAL CELL

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

(2010) Elke Piters et al.   HUMAN MUTATION

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

(2010) Carola Krause et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspective how many women have osteoporosis?

(2010) L. Joseph Melton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR structure of the Wnt modulator protein Sclerostin

(2009) Stella E. Weidauer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The −9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPα and FOXA1 binding is associated with osteoporosis

(2009) Qing-Yang Huang et al.   BONE

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Folding and Ligand-binding Properties of LRP6 β-Propeller Domains

(2009) Chia-Chen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals

(2009) Katherine B. Lintern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Short Treatment With an Antibody to Sclerostin Can Inhibit Bone Loss in an Ongoing Model of Colitis*

(2009) Alison Eddleston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Kinetics of Wnt-Driven β-Catenin Stabilization Revealed by Quantitative and Temporal Imaging

(2008) Rami N. Hannoush   PLoS One