New roles for old modifications: Emerging roles of N-terminal post-translational modifications in development and disease

α-N-Methylation of Damaged DNA-binding Protein 2 (DDB2) and Its Function in Nucleotide Excision Repair

(2014) Qian Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein folding

(2014) William M. Holmes et al.   Nature Communications

NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1

(2013) Janusz J. Petkowski et al.   BIOCHEMICAL JOURNAL

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

(2013) Michael H. Tatham et al.   BIOCHEMICAL JOURNAL

The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates

(2013) Kenneth Matthew Scaglione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes

(2013) Igor Dikiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel α-N-Methylation of CENP-B That Regulates Its Binding to the Centromeric DNA

(2013) Xiaoxia Dai et al.   JOURNAL OF PROTEOME RESEARCH

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

N-Terminal methylation of proteasome subunit Rpt1 in yeast

(2013) Yayoi Kimura et al.   PROTEOMICS

Substrate Specificity of Mammalian N-Terminal α-Amino Methyltransferase NRMT

(2012) Janusz J. Petkowski et al.   BIOCHEMISTRY

The bromodomain interaction module

(2012) Panagis Filippakopoulos et al.   FEBS LETTERS

Protein N-terminal Acetyltransferases Act as N-terminal PropionyltransferasesIn VitroandIn Vivo

(2012) Håvard Foyn et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein N-terminal acetyltransferases in cancer

(2012) T V Kalvik et al.   ONCOGENE

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency

(2011) Alan F. Rope et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenetic virtues of chromodomains

(2011) Bartlomiej J. Blus et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

OPERating ON Chromatin, a Colorful Language where Context Matters

(2011) Kathryn E. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

UBE2W interacts with FANCL and regulates the monoubiquitination of fanconi anemia protein FANCD2

(2011) Yingying Zhang et al.   MOLECULES AND CELLS

Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster

(2011) Ana Villar-Garea et al.   NUCLEIC ACIDS RESEARCH

The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4

(2011) Kristine Hole et al.   PLoS One

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

(2011) Gabriella M. A. Forte et al.   PLOS BIOLOGY

Identification of Protein N-Terminal Methyltransferases in Yeast and Humans

(2010) Kristofor J. Webb et al.   BIOCHEMISTRY

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

(2010) Chung-Fan Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The Chaperone-Like Protein HYPK Acts Together with NatA in Cotranslational N-Terminal Acetylation and Prevention of Huntingtin Aggregation

(2010) T. Arnesen et al.   MOLECULAR AND CELLULAR BIOLOGY

NRMT is an α-N-methyltransferase that methylates RCC1 and retinoblastoma protein

(2010) Christine E. Schaner Tooley et al.   NATURE

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway

(2010) H.-P. Kuo et al.   Science Signaling

Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells

(2009) Zhen Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Identification and Characterization of Propionylation at Histone H3 Lysine 23 in Mammalian Cells

(2009) Bo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A proteomics approach to study in vivo protein Nα-modifications

(2009) Xumin Zhang et al.   Journal of Proteomics

Arrest Defective-1 Controls Tumor Cell Behavior by Acetylating Myosin Light Chain Kinase

(2009) Dong Hoon Shin et al.   PLoS One

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster

(2009) Sandra Goetze et al.   PLOS BIOLOGY

Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis

(2008) Md Alamgir et al.   BMC GENOMICS

Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer

(2008) Tingting Ren et al.   CANCER LETTERS

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis

(2008) Verena Brune et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

(2008) Arno F. Alpi et al.   MOLECULAR CELL

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Implication of human N-α-acetyltransferase 5 in cellular proliferation and carcinogenesis

(2008) A Ametzazurra et al.   ONCOGENE