Protein N-terminal acetyltransferases in cancer

Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency

(2011) Alan F. Rope et al.   AMERICAN JOURNAL OF HUMAN GENETICS

N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

(2011) Kuo-Tai Hua et al.   CANCER CELL

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

(2011) Caroline H. Yi et al.   CELL

Bioinformatics Analysis of aSaccharomyces cerevisiaeN-Terminal Proteome Provides Evidence of Alternative Translation Initiation and Post-Translational N-Terminal Acetylation

(2011) Kenny Helsens et al.   JOURNAL OF PROTEOME RESEARCH

Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-translational Actin Nα-acetyltransferase

(2011) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS

The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4

(2011) Kristine Hole et al.   PLoS One

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

Towards a Functional Understanding of Protein N-Terminal Acetylation

(2011) Thomas Arnesen   PLOS BIOLOGY

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

(2011) Gabriella M. A. Forte et al.   PLOS BIOLOGY

NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation

(2011) Petra Van Damme et al.   PLoS Genetics

Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels

(2010) Andreas O Helbig et al.   BMC GENOMICS

Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

(2010) Ji Hae Seo et al.   CANCER RESEARCH

Depletion of the human Nα-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition

(2010) Darina Gromyko et al.   INTERNATIONAL JOURNAL OF CANCER

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast

(2010) A. T. Coulton et al.   JOURNAL OF CELL SCIENCE

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

(2010) Chung-Fan Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The Chaperone-Like Protein HYPK Acts Together with NatA in Cotranslational N-Terminal Acetylation and Prevention of Huntingtin Aggregation

(2010) T. Arnesen et al.   MOLECULAR AND CELLULAR BIOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway

(2010) H.-P. Kuo et al.   Science Signaling

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma

(2010) Guo-Liang Huang   WORLD JOURNAL OF GASTROENTEROLOGY

Correlation of Expression of Human Arrest-Defective-1 (hARD1) Protein With Breast Cancer

(2009) Min Yu et al.   CANCER INVESTIGATION

Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells

(2009) Zhen Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human Naa50p (Nat5/San) Displays Both ProteinNα- andNϵ-Acetyltransferase Activity

(2009) Rune Evjenth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of Human N -Terminal Acetyltransferase Complex C Leads to p53-Dependent Apoptosis and Aberrant Human Arl8b Localization

(2009) K. K. Starheim et al.   MOLECULAR AND CELLULAR BIOLOGY

Arrest Defective-1 Controls Tumor Cell Behavior by Acetylating Myosin Light Chain Kinase

(2009) Dong Hoon Shin et al.   PLoS One

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Identification of the humanNα-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression

(2008) Kristian K. Starheim et al.   BIOCHEMICAL JOURNAL

Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer

(2008) Tingting Ren et al.   CANCER LETTERS

Hypoxia-Inducible Factor-1  Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of  -Catenin

(2008) J.-H. Lim et al.   CANCER RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Differential requirements of a mitotic acetyltransferase in somatic and germ line cells

(2008) Ana Pimenta-Marques et al.   DEVELOPMENTAL BIOLOGY

Implication of human N-α-acetyltransferase 5 in cellular proliferation and carcinogenesis

(2008) A Ametzazurra et al.   ONCOGENE

Yeast Nα-terminal acetyltransferases are associated with ribosomes

(2007) Bogdan Polevoda et al.   JOURNAL OF CELLULAR BIOCHEMISTRY