ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura – current perspectives and new treatment strategies

Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic PurpuraSignificance

(2015) Claudia Tersteeg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models

(2015) B. Pickens et al.   BLOOD

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies

(2015) M. Jiménez-Alcázar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role of N-acetylcysteine in the treatment of thrombotic thrombocytopenic purpura

(2015) Amihai Rottenstreich et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome

(2015) Veronica C. Casina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Acetylcysteine for thrombotic thrombocytopenic purpura: is a von Willebrand factor-inhibitory dose feasible in vivo?

(2015) Jake Shortt et al.   TRANSFUSION

The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs

(2014) M. Schaller et al.   BLOOD

Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes

(2014) M. Scully et al.   BLOOD

Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP

(2014) S. R. Cataland et al.   BLOOD

Acquired TTP: ADAMTS13 meets the immune system

(2014) Fabian C. Verbij et al.   BLOOD REVIEWS

Of von Willebrand factor and platelets

(2014) Marijke Bryckaert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Plasmin Cleavage of von Willebrand Factor as an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy

(2014) Claudia Tersteeg et al.   CIRCULATION

Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura

(2014) R. Grillberger et al.   HAEMATOLOGICA

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

(2014) Salima Hacein-Bey-Abina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B

(2014) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Allosteric activation of ADAMTS13 by von Willebrand factor

(2014) Joshua Muia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational activation of ADAMTS13

(2014) Kieron South et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inherited ADAMTS13 deficiency (Upshaw-Schulman syndrome): A short review

(2014) Almudena Pérez-Rodríguez et al.   THROMBOSIS RESEARCH

Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells

(2013) N. Sorvillo et al.   BLOOD

AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura

(2013) S.-Y. Jin et al.   BLOOD

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

(2013) John-Paul Westwood et al.   BRITISH JOURNAL OF HAEMATOLOGY

Experiences in a Family With the Upshaw-Schulman Syndrome Over a 44-Year Period

(2013) Michael Bennett et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Persistence of circulating ADAMTS13-specific immune complexes in patients with acquired thrombotic thrombocytopenic purpura

(2013) S. Ferrari et al.   HAEMATOLOGICA

Acquired thrombotic thrombocytopenic purpura

(2013) M. Schaller et al.   Hamostaseologie

Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry

(2013) M. Mansouri Taleghani et al.   Hamostaseologie

Complement Activation Associated with ADAMTS13 Deficiency in Human and Murine Thrombotic Microangiopathy

(2013) R. Tati et al.   JOURNAL OF IMMUNOLOGY

Measurement and prevalence of circulating ADAMTS13-specific immune complexes in autoimmune thrombotic thrombocytopenic purpura

(2013) L. A. Lotta et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombotic microangiopathies

(2013) Michael H. Rosove   SEMINARS IN ARTHRITIS AND RHEUMATISM

Treatment of refractory thrombotic thrombocytopenic purpura withN-acetylcysteine: a case report

(2013) Gloria W. Li et al.   TRANSFUSION

PROTEOLYTIC PROCESSING OF VON WILLEBRAND FACTOR BY ADAMTS13 AND LEUKOCYTE PROTEASES

(2013) Stefano Lancellotti et al.   Mediterranean Journal of Hematology and Infectious Diseases

Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

(2012) H. B. Feys et al.   BLOOD

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13

(2012) A. Schiviz et al.   BLOOD

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2012) C. Jian et al.   BLOOD

Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura

(2012) F. Callewaert et al.   BLOOD

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies

(2012) T. A. Fuchs et al.   BLOOD

Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura

(2012) M. Moatti-Cohen et al.   BLOOD

A phenotype-genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom

(2012) R. S. CAMILLERI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement activation in thrombotic thrombocytopenic purpura

(2012) M. RÉTI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ADAMTS-13 activity and autoantibodies classes and subclasses as prognostic predictors in acquired thrombotic thrombocytopenic purpura

(2012) G. BETTONI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rituximab for thrombotic thrombocytopenic purpura: benefit of early administration during acute episodes and use of prophylaxis to prevent relapse

(2012) J-P. Westwood et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The homozygous p.C1024R-ADAMTS13 gene mutation links to a late-onset phenotype of Upshaw-Schulman syndrome in Japan

(2012) Fumihiro Taguchi et al.   THROMBOSIS AND HAEMOSTASIS

The TITAN trial – Assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura

(2012) Josefin-Beate Holz   TRANSFUSION AND APHERESIS SCIENCE

Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura

(2011) Spero R. Cataland et al.   AMERICAN JOURNAL OF HEMATOLOGY

A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura

(2011) M. Scully et al.   BLOOD

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

(2011) J. T. B. Crawley et al.   BLOOD

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

(2011) W. Pos et al.   HAEMATOLOGICA

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

(2011) Junmei Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Recombinant ADAMTS13 normalizes von Willebrand factor-cleaving activity in plasma of acquired TTP patients by overriding inhibitory antibodies

(2011) B. PLAIMAUER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2011) Yusuke Yamaguchi et al.   THROMBOSIS RESEARCH

Modulation of the von Willebrand factor-dependent platelet adhesion through alternative proteolytic pathways

(2011) Nikolett Wohner et al.   THROMBOSIS RESEARCH

How I treat patients with thrombotic thrombocytopenic purpura: 2010

(2010) J. N. George   BLOOD

The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions

(2010) Y. M. LUCISANO VALIM et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Selective IgG subclass deficiency: quantification and clinical relevance

(2010) R. JEFFERIS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

(2010) X. L. Zheng et al.   HAEMATOLOGICA

Registry of 919 Patients with Thrombotic Microangiopathies across Japan: Database of Nara Medical University during 1998-2008

(2010) Yoshihiro Fujimura et al.   INTERNAL MEDICINE

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura

(2010) H. B. FEYS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

(2009) T. J. Raife et al.   BLOOD

Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy

(2009) P. Laje et al.   BLOOD

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

(2009) S. Zanardelli et al.   BLOOD

Survival and relapse in patients with thrombotic thrombocytopenic purpura

(2009) J. A. K. Hovinga et al.   BLOOD

Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice

(2009) P Trionfini et al.   GENE THERAPY

IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura

(2009) S. FERRARI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Imitators of Severe Pre-eclampsia

(2009) Baha M. Sibai   SEMINARS IN PERINATOLOGY

The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation

(2008) F. Banno et al.   BLOOD

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

(2008) F. Peyvandi et al.   HAEMATOLOGICA

Translational applications of antibody phage display

(2008) Don L. Siegel   IMMUNOLOGIC RESEARCH

VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2008) W. POS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Correction of ADAMTS13 Deficiency by In Utero Gene Transfer of Lentiviral Vector encoding ADAMTS13 Genes

(2008) Masami Niiya et al.   MOLECULAR THERAPY