High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome

The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs

(2014) M. Schaller et al.   BLOOD

Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13

(2014) N. Sorvillo et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Carboxyl Terminus of ADAMTS13 Directly Inhibits Platelet Aggregation and Ultra Large von Willebrand Factor String Formation Under Flow in a Free-Thiol–Dependent Manner

(2013) Jialing Bao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura

(2013) S.-Y. Jin et al.   BLOOD

Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis

(2013) Z.-Y. Kan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

(2013) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2012) C. Jian et al.   BLOOD

Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking

(2012) Deepangi Pandit et al.   JOURNAL OF MOLECULAR RECOGNITION

Minimizing Back Exchange in the Hydrogen Exchange-Mass Spectrometry Experiment

(2012) Benjamin T. Walters et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Fragmentation hydrogen exchange mass spectrometry: A review of methodology and applications

(2012) Ansgar Brock   PROTEIN EXPRESSION AND PURIFICATION

Protein hydrogen exchange: Testing current models

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Epitope Mapping of a 95 kDa Antigen in Complex with Antibody by Solution-Phase Amide Backbone Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2011) Qian Zhang et al.   ANALYTICAL CHEMISTRY

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

(2011) W. Pos et al.   HAEMATOLOGICA

ExMS: Data Analysis for HX-MS Experiments

(2011) Zhong-Yuan Kan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Many Overlapping Peptides for Protein Hydrogen Exchange Experiments by the Fragment Separation-Mass Spectrometry Method

(2011) Leland Mayne et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A shear-based assay for assessing plasma ADAMTS13 activity and inhibitors in patients with thrombotic thrombocytopenic purpura

(2011) Yue Han et al.   TRANSFUSION

Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

(2010) S.-Y. Jin et al.   BLOOD

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

(2010) X. L. Zheng et al.   HAEMATOLOGICA

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

(2009) T. J. Raife et al.   BLOOD

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

(2009) W. Pos et al.   BLOOD

Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry

(2009) Stephen J. Coales et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

(2008) W. Gao et al.   BLOOD

Crystal Structures of the Pro-Inflammatory Cytokine Interleukin-23 and Its Complex with a High-Affinity Neutralizing Antibody

(2008) Brian M. Beyer et al.   JOURNAL OF MOLECULAR BIOLOGY

VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2008) W. POS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS